<?xml version="1.0" encoding="UTF-8"?><xmi:XMI xmlns:pos="http:///org/u_compare/shared/label/penn/pos.ecore" xmlns:grammatical="http:///org/u_compare/shared/label/penn/function/grammatical.ecore" xmlns:general="http:///org/u_compare/shared/label/penn/pos/general.ecore" xmlns:cas="http:///uima/cas.ecore" xmlns:stanford="http:///org/u_compare/shared/label/stanford.ecore" xmlns:semantic2="http:///uk/ac/nactem/semantic.ecore" xmlns:bioie="http:///org/u_compare/shared/label/penn/pos/bioie.ecore" xmlns:function="http:///org/u_compare/shared/label/penn/function.ecore" xmlns:tcas="http:///uima/tcas.ecore" xmlns:bio="http:///org/u_compare/shared/semantic/bio.ecore" xmlns:syntactic="http:///org/u_compare/shared/syntactic.ecore" xmlns:comparable="http:///org/u_compare/shared/comparable.ecore" xmlns:examples="http:///org/apache/uima/examples.ecore" xmlns:label="http:///org/u_compare/shared/label.ecore" xmlns:xmi="http://www.omg.org/XMI" xmlns:general2="http:///org/u_compare/shared/label/penn/bracket/general.ecore" xmlns:shared="http:///org/u_compare/shared.ecore" xmlns:fragment="http:///org/u_compare/shared/document/fragment.ecore" xmlns:document="http:///org/u_compare/shared/document.ecore" xmlns:bracket="http:///org/u_compare/shared/label/penn/bracket.ecore" xmlns:text="http:///org/u_compare/shared/label/penn/function/text.ecore" xmlns:structure="http:///org/u_compare/shared/document/structure.ecore" xmlns:text2="http:///org/u_compare/shared/document/text.ecore" xmlns:release="http:///org/u_compare/shared/label/penn/pos/release.ecore" xmlns:semantic="http:///org/u_compare/shared/semantic.ecore" xmlns:nontext="http:///org/u_compare/shared/document/nontext.ecore" xmlns:conll="http:///org/u_compare/shared/label/conll.ecore" xmlns:chemical="http:///org/u_compare/shared/semantic/chemical.ecore" xmlns:semantic3="http:///org/u_compare/shared/label/penn/function/semantic.ecore" xmlns:release2="http:///org/u_compare/shared/label/penn/bracket/release.ecore" xmlns:coindex="http:///org/u_compare/shared/label/penn/coindex.ecore" xmi:version="2.0"><cas:NULL xmi:id="0"/><cas:Sofa xmi:id="1" sofaNum="1" sofaID="_InitialView" mimeType="text" sofaString="Autoregulation of PurR repressor synthesis and involvement of purR in the regulation of purB, purC, purL, purMN and guaBA expression in Escherichia coli. &#10;The purR gene encodes a repressor (PurR) controlling the synthesis of the enzymes of purine biosynthesis. The subunit of PurR was identified as a 38-kDa polypeptide by SDS/polyacrylamide gel electrophoresis. Analysis of a purR-lacZ transcriptional fusion indicated that purR expression is autoregulated. This was confirmed by gel retardation and DNaseI footprinting experiments, where two PurR-binding sites were identified in the transcribed part of purR. Introduction of a purR mutation in wild-type and pur-lac fusion strains was found to abolish purine repression of all genes of the purine biosynthetic pathway except for purA. "/><cas:FSArray xmi:id="462" elements="465"/><cas:FSArray xmi:id="468" elements="26"/><cas:FSArray xmi:id="474" elements="478 487"/><cas:FSArray xmi:id="481" elements="341"/><cas:FSArray xmi:id="490" elements="88"/><cas:FSArray xmi:id="496" elements="500 513"/><cas:FSArray xmi:id="503" elements="33 44 55 66 77"/><cas:FSArray xmi:id="516" elements="88"/><cas:FSArray xmi:id="522" elements="526 535"/><cas:FSArray xmi:id="529" elements="106"/><cas:FSArray xmi:id="538" elements="117"/><cas:FSArray xmi:id="544" elements="548 557"/><cas:FSArray xmi:id="551" elements="117"/><cas:FSArray xmi:id="560" elements="374"/><cas:FSArray xmi:id="566" elements="569"/><cas:FSArray xmi:id="572" elements="128"/><cas:FSArray xmi:id="578" elements="581"/><cas:FSArray xmi:id="584" elements="139"/><cas:FSArray xmi:id="590" elements="593"/><cas:FSArray xmi:id="596" elements="385"/><cas:FSArray xmi:id="602" elements="606 615"/><cas:FSArray xmi:id="609" elements="150"/><cas:FSArray xmi:id="618" elements="161"/><cas:FSArray xmi:id="624" elements="628 637"/><cas:FSArray xmi:id="631" elements="429"/><cas:FSArray xmi:id="640" elements="179"/><cas:FSArray xmi:id="646" elements="649"/><cas:FSArray xmi:id="652" elements="168"/><cas:FSArray xmi:id="658" elements="662 671"/><cas:FSArray xmi:id="665" elements="418"/><cas:FSArray xmi:id="674" elements="451"/><cas:FSArray xmi:id="680" elements="684 693"/><cas:FSArray xmi:id="687" elements="197"/><cas:FSArray xmi:id="696" elements="204"/><cas:FSArray xmi:id="705" elements="0 26 33 44 55 66 77 88 95 106 117 128 139 150 161 168 179 186 197 204 0 0 0 0 0 0 0 0 0 0 0 0 0"/><tcas:DocumentAnnotation xmi:id="8" sofa="1" begin="0" end="788" language="x-unspecified"/><tcas:DocumentAnnotation xmi:id="21" sofa="1" begin="0" end="788"/><examples:SourceDocumentInformation xmi:id="13" sofa="1" begin="0" end="788" uri="/2404765.txt" offsetInSource="0" documentSize="788" lastSegment="true"/><semantic:LinkedAnnotationSet xmi:id="465" linkingRelation="471" linkedAnnotations="468"/><semantic:LinkedAnnotationSet xmi:id="478" linkingRelation="484" linkedAnnotations="481"/><semantic:LinkedAnnotationSet xmi:id="487" linkingRelation="493" linkedAnnotations="490"/><semantic:LinkedAnnotationSet xmi:id="500" linkingRelation="510" linkedAnnotations="503"/><semantic:LinkedAnnotationSet xmi:id="513" linkingRelation="519" linkedAnnotations="516"/><semantic:LinkedAnnotationSet xmi:id="526" linkingRelation="532" linkedAnnotations="529"/><semantic:LinkedAnnotationSet xmi:id="535" linkingRelation="541" linkedAnnotations="538"/><semantic:LinkedAnnotationSet xmi:id="548" linkingRelation="554" linkedAnnotations="551"/><semantic:LinkedAnnotationSet xmi:id="557" linkingRelation="563" linkedAnnotations="560"/><semantic:LinkedAnnotationSet xmi:id="569" linkingRelation="575" linkedAnnotations="572"/><semantic:LinkedAnnotationSet xmi:id="581" linkingRelation="587" linkedAnnotations="584"/><semantic:LinkedAnnotationSet xmi:id="593" linkingRelation="599" linkedAnnotations="596"/><semantic:LinkedAnnotationSet xmi:id="606" linkingRelation="612" linkedAnnotations="609"/><semantic:LinkedAnnotationSet xmi:id="615" linkingRelation="621" linkedAnnotations="618"/><semantic:LinkedAnnotationSet xmi:id="628" linkingRelation="634" linkedAnnotations="631"/><semantic:LinkedAnnotationSet xmi:id="637" linkingRelation="643" linkedAnnotations="640"/><semantic:LinkedAnnotationSet xmi:id="649" linkingRelation="655" linkedAnnotations="652"/><semantic:LinkedAnnotationSet xmi:id="662" linkingRelation="668" linkedAnnotations="665"/><semantic:LinkedAnnotationSet xmi:id="671" linkingRelation="677" linkedAnnotations="674"/><semantic:LinkedAnnotationSet xmi:id="684" linkingRelation="690" linkedAnnotations="687"/><semantic:LinkedAnnotationSet xmi:id="693" linkingRelation="699" linkedAnnotations="696"/><shared:ExternalReference xmi:id="41" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="52" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="63" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="74" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="85" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="103" namespace="GREC Concepts" ID="Wild_Type_Bacteria"/><shared:ExternalReference xmi:id="114" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="125" namespace="GREC Concepts" ID="Repressor"/><shared:ExternalReference xmi:id="136" namespace="GREC Concepts" ID="Enzyme"/><shared:ExternalReference xmi:id="147" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="158" namespace="GREC Concepts" ID="Transcription_Binding_Site"/><shared:ExternalReference xmi:id="176" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="194" namespace="GREC Concepts" ID="Bacteria"/><shared:ExternalReference xmi:id="212" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="327" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="338" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="349" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="360" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="371" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="382" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="393" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="404" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="415" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="426" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="437" namespace="GREC" ID="Mutation"/><shared:ExternalReference xmi:id="448" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="459" namespace="GREC" ID="Gene_Repression"/><shared:ExternalReference xmi:id="471" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="484" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="493" namespace="GREC Concepts" ID="Location"/><shared:ExternalReference xmi:id="510" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="519" namespace="GREC Concepts" ID="Location"/><shared:ExternalReference xmi:id="532" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="541" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="554" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="563" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="575" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="587" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="599" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="612" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="621" namespace="GREC Concepts" ID="Location"/><shared:ExternalReference xmi:id="634" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="643" namespace="GREC Concepts" ID="Location"/><shared:ExternalReference xmi:id="655" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="668" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="677" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="690" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="699" namespace="GREC Concepts" ID="Theme"/><semantic:EventAnnotation xmi:id="319" sofa="1" begin="0" end="14" externalReference="327" linkedAnnotationSets="462"/><semantic:EventAnnotation xmi:id="330" sofa="1" begin="74" end="84" externalReference="338" linkedAnnotationSets="474"/><semantic:EventAnnotation xmi:id="341" sofa="1" begin="122" end="132" externalReference="349" linkedAnnotationSets="496"/><semantic:EventAnnotation xmi:id="352" sofa="1" begin="169" end="176" externalReference="360" linkedAnnotationSets="522"/><semantic:EventAnnotation xmi:id="363" sofa="1" begin="196" end="207" externalReference="371" linkedAnnotationSets="544"/><semantic:EventAnnotation xmi:id="374" sofa="1" begin="212" end="221" externalReference="382" linkedAnnotationSets="566"/><semantic:EventAnnotation xmi:id="385" sofa="1" begin="430" end="440" externalReference="393" linkedAnnotationSets="578"/><semantic:EventAnnotation xmi:id="396" sofa="1" begin="444" end="457" externalReference="404" linkedAnnotationSets="590"/><semantic:EventAnnotation xmi:id="407" sofa="1" begin="568" end="578" externalReference="415" linkedAnnotationSets="602"/><semantic:EventAnnotation xmi:id="418" sofa="1" begin="612" end="624" externalReference="426" linkedAnnotationSets="624"/><semantic:EventAnnotation xmi:id="429" sofa="1" begin="635" end="643" externalReference="437" linkedAnnotationSets="646"/><semantic:EventAnnotation xmi:id="440" sofa="1" begin="697" end="704" externalReference="448" linkedAnnotationSets="658"/><semantic:EventAnnotation xmi:id="451" sofa="1" begin="712" end="722" externalReference="459" linkedAnnotationSets="680"/><comparable:IDArray xmi:id="702" array="705" idType="t"/><semantic2:NucleicAcids xmi:id="33" sofa="1" begin="88" end="92" externalReference="41"/><semantic2:NucleicAcids xmi:id="44" sofa="1" begin="94" end="98" externalReference="52"/><semantic2:NucleicAcids xmi:id="55" sofa="1" begin="100" end="104" externalReference="63"/><semantic2:NucleicAcids xmi:id="66" sofa="1" begin="106" end="111" externalReference="74"/><semantic2:NucleicAcids xmi:id="77" sofa="1" begin="116" end="121" externalReference="85"/><semantic2:NucleicAcids xmi:id="106" sofa="1" begin="155" end="168" externalReference="114"/><semantic2:NucleicAcids xmi:id="139" sofa="1" begin="425" end="429" externalReference="147"/><semantic2:NucleicAcids xmi:id="150" sofa="1" begin="540" end="562" externalReference="158"/><semantic2:NucleicAcids xmi:id="168" sofa="1" begin="630" end="634" externalReference="176"/><semantic2:NucleicAcids xmi:id="204" sofa="1" begin="726" end="735" externalReference="212"/><semantic2:Proteins xmi:id="117" sofa="1" begin="190" end="194" externalReference="125"/><semantic2:Proteins xmi:id="128" sofa="1" begin="225" end="236" externalReference="136"/><semantic2:LivingSystems xmi:id="95" sofa="1" begin="136" end="152" externalReference="103"/><semantic2:LivingSystems xmi:id="186" sofa="1" begin="647" end="683" externalReference="194"/><semantic2:EventArgumentSpan xmi:id="26" sofa="1" begin="18" end="42"/><semantic2:EventArgumentSpan xmi:id="88" sofa="1" begin="133" end="152"/><semantic2:EventArgumentSpan xmi:id="161" sofa="1" begin="579" end="610"/><semantic2:EventArgumentSpan xmi:id="179" sofa="1" begin="644" end="683"/><semantic2:EventArgumentSpan xmi:id="197" sofa="1" begin="705" end="711"/><cas:View sofa="1" members="462 468 474 481 490 496 503 516 522 529 538 544 551 560 566 572 578 584 590 596 602 609 618 624 631 640 646 652 658 665 674 680 687 696 705 8 21 13 465 478 487 500 513 526 535 548 557 569 581 593 606 615 628 637 649 662 671 684 693 41 52 63 74 85 103 114 125 136 147 158 176 194 212 327 338 349 360 371 382 393 404 415 426 437 448 459 471 484 493 510 519 532 541 554 563 575 587 599 612 621 634 643 655 668 677 690 699 319 330 341 352 363 374 385 396 407 418 429 440 451 702 33 44 55 66 77 106 139 150 168 204 117 128 95 186 26 88 161 179 197"/></xmi:XMI>