<?xml version="1.0" encoding="UTF-8"?><xmi:XMI xmlns:pos="http:///org/u_compare/shared/label/penn/pos.ecore" xmlns:grammatical="http:///org/u_compare/shared/label/penn/function/grammatical.ecore" xmlns:general="http:///org/u_compare/shared/label/penn/pos/general.ecore" xmlns:cas="http:///uima/cas.ecore" xmlns:stanford="http:///org/u_compare/shared/label/stanford.ecore" xmlns:semantic2="http:///uk/ac/nactem/semantic.ecore" xmlns:bioie="http:///org/u_compare/shared/label/penn/pos/bioie.ecore" xmlns:function="http:///org/u_compare/shared/label/penn/function.ecore" xmlns:tcas="http:///uima/tcas.ecore" xmlns:bio="http:///org/u_compare/shared/semantic/bio.ecore" xmlns:syntactic="http:///org/u_compare/shared/syntactic.ecore" xmlns:comparable="http:///org/u_compare/shared/comparable.ecore" xmlns:examples="http:///org/apache/uima/examples.ecore" xmlns:label="http:///org/u_compare/shared/label.ecore" xmlns:xmi="http://www.omg.org/XMI" xmlns:general2="http:///org/u_compare/shared/label/penn/bracket/general.ecore" xmlns:shared="http:///org/u_compare/shared.ecore" xmlns:fragment="http:///org/u_compare/shared/document/fragment.ecore" xmlns:document="http:///org/u_compare/shared/document.ecore" xmlns:bracket="http:///org/u_compare/shared/label/penn/bracket.ecore" xmlns:text="http:///org/u_compare/shared/label/penn/function/text.ecore" xmlns:structure="http:///org/u_compare/shared/document/structure.ecore" xmlns:text2="http:///org/u_compare/shared/document/text.ecore" xmlns:release="http:///org/u_compare/shared/label/penn/pos/release.ecore" xmlns:semantic="http:///org/u_compare/shared/semantic.ecore" xmlns:nontext="http:///org/u_compare/shared/document/nontext.ecore" xmlns:conll="http:///org/u_compare/shared/label/conll.ecore" xmlns:chemical="http:///org/u_compare/shared/semantic/chemical.ecore" xmlns:semantic3="http:///org/u_compare/shared/label/penn/function/semantic.ecore" xmlns:release2="http:///org/u_compare/shared/label/penn/bracket/release.ecore" xmlns:coindex="http:///org/u_compare/shared/label/penn/coindex.ecore" xmi:version="2.0"><cas:NULL xmi:id="0"/><cas:Sofa xmi:id="1" sofaNum="1" sofaID="_InitialView" mimeType="text" sofaString="A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. &#10;Erythroid Krüppel-like factor (EKLF) is necessary for stage-specific expression of the human beta-globin gene. We show that EKLF requires a SWI/SNF-related chromatin remodeling complex, EKLF coactivator-remodeling complex 1 (E-RC1), to generate a DNase I hypersensitive, transcriptionally active beta-globin promoter on chromatin templates in vitro. E-RC1 contains BRG1, BAF170, BAF155, and INI1 (BAF47) homologs of yeast SWI/SNF subunits, as well as a subunit unique to higher eukaryotes, BAF57, which is critical for chromatin remodeling and transcription with EKLF. E-RC1 displays functional selectivity toward transcription factors, since it cannot activate expression of chromatin-assembled HIV-1 templates with the E box-binding protein TFE-3. Thus, a member of the SWI/SNF family acts directly in transcriptional activation and may regulate subsets of genes by selectively interacting with specific DNA-binding proteins. "/><cas:FSArray xmi:id="449" elements="453 462"/><cas:FSArray xmi:id="456" elements="26"/><cas:FSArray xmi:id="465" elements="328"/><cas:FSArray xmi:id="471" elements="476 485 494"/><cas:FSArray xmi:id="479" elements="44"/><cas:FSArray xmi:id="488" elements="37"/><cas:FSArray xmi:id="497" elements="55"/><cas:FSArray xmi:id="503" elements="507 516"/><cas:FSArray xmi:id="510" elements="69"/><cas:FSArray xmi:id="519" elements="62"/><cas:FSArray xmi:id="525" elements="530 539 548"/><cas:FSArray xmi:id="533" elements="80"/><cas:FSArray xmi:id="542" elements="91"/><cas:FSArray xmi:id="551" elements="361"/><cas:FSArray xmi:id="557" elements="563 572 581 590"/><cas:FSArray xmi:id="566" elements="80"/><cas:FSArray xmi:id="575" elements="102"/><cas:FSArray xmi:id="584" elements="113"/><cas:FSArray xmi:id="593" elements="120"/><cas:FSArray xmi:id="599" elements="603 612"/><cas:FSArray xmi:id="606" elements="127"/><cas:FSArray xmi:id="615" elements="138"/><cas:FSArray xmi:id="621" elements="625 634"/><cas:FSArray xmi:id="628" elements="149"/><cas:FSArray xmi:id="637" elements="394"/><cas:FSArray xmi:id="643" elements="646"/><cas:FSArray xmi:id="649" elements="160"/><cas:FSArray xmi:id="655" elements="660 669 678"/><cas:FSArray xmi:id="663" elements="167"/><cas:FSArray xmi:id="672" elements="178"/><cas:FSArray xmi:id="681" elements="416"/><cas:FSArray xmi:id="687" elements="690"/><cas:FSArray xmi:id="693" elements="185"/><cas:FSArray xmi:id="699" elements="704 713 722"/><cas:FSArray xmi:id="707" elements="167"/><cas:FSArray xmi:id="716" elements="192"/><cas:FSArray xmi:id="725" elements="438"/><cas:FSArray xmi:id="731" elements="736 745 754"/><cas:FSArray xmi:id="739" elements="210"/><cas:FSArray xmi:id="748" elements="167"/><cas:FSArray xmi:id="757" elements="203"/><cas:FSArray xmi:id="766" elements="0 26 37 44 55 62 69 80 91 102 113 120 127 138 149 160 167 178 185 192 203 210 0 0 0 0 0 0 0 0 0 0 0 0"/><tcas:DocumentAnnotation xmi:id="8" sofa="1" begin="0" end="1061" language="x-unspecified"/><tcas:DocumentAnnotation xmi:id="21" sofa="1" begin="0" end="1061"/><examples:SourceDocumentInformation xmi:id="13" sofa="1" begin="0" end="1061" uri="/9778250.txt" offsetInSource="0" documentSize="1061" lastSegment="true"/><semantic:LinkedAnnotationSet xmi:id="453" linkingRelation="459" linkedAnnotations="456"/><semantic:LinkedAnnotationSet xmi:id="462" linkingRelation="468" linkedAnnotations="465"/><semantic:LinkedAnnotationSet xmi:id="476" linkingRelation="482" linkedAnnotations="479"/><semantic:LinkedAnnotationSet xmi:id="485" linkingRelation="491" linkedAnnotations="488"/><semantic:LinkedAnnotationSet xmi:id="494" linkingRelation="500" linkedAnnotations="497"/><semantic:LinkedAnnotationSet xmi:id="507" linkingRelation="513" linkedAnnotations="510"/><semantic:LinkedAnnotationSet xmi:id="516" linkingRelation="522" linkedAnnotations="519"/><semantic:LinkedAnnotationSet xmi:id="530" linkingRelation="536" linkedAnnotations="533"/><semantic:LinkedAnnotationSet xmi:id="539" linkingRelation="545" linkedAnnotations="542"/><semantic:LinkedAnnotationSet xmi:id="548" linkingRelation="554" linkedAnnotations="551"/><semantic:LinkedAnnotationSet xmi:id="563" linkingRelation="569" linkedAnnotations="566"/><semantic:LinkedAnnotationSet xmi:id="572" linkingRelation="578" linkedAnnotations="575"/><semantic:LinkedAnnotationSet xmi:id="581" linkingRelation="587" linkedAnnotations="584"/><semantic:LinkedAnnotationSet xmi:id="590" linkingRelation="596" linkedAnnotations="593"/><semantic:LinkedAnnotationSet xmi:id="603" linkingRelation="609" linkedAnnotations="606"/><semantic:LinkedAnnotationSet xmi:id="612" linkingRelation="618" linkedAnnotations="615"/><semantic:LinkedAnnotationSet xmi:id="625" linkingRelation="631" linkedAnnotations="628"/><semantic:LinkedAnnotationSet xmi:id="634" linkingRelation="640" linkedAnnotations="637"/><semantic:LinkedAnnotationSet xmi:id="646" linkingRelation="652" linkedAnnotations="649"/><semantic:LinkedAnnotationSet xmi:id="660" linkingRelation="666" linkedAnnotations="663"/><semantic:LinkedAnnotationSet xmi:id="669" linkingRelation="675" linkedAnnotations="672"/><semantic:LinkedAnnotationSet xmi:id="678" linkingRelation="684" linkedAnnotations="681"/><semantic:LinkedAnnotationSet xmi:id="690" linkingRelation="696" linkedAnnotations="693"/><semantic:LinkedAnnotationSet xmi:id="704" linkingRelation="710" linkedAnnotations="707"/><semantic:LinkedAnnotationSet xmi:id="713" linkingRelation="719" linkedAnnotations="716"/><semantic:LinkedAnnotationSet xmi:id="722" linkingRelation="728" linkedAnnotations="725"/><semantic:LinkedAnnotationSet xmi:id="736" linkingRelation="742" linkedAnnotations="739"/><semantic:LinkedAnnotationSet xmi:id="745" linkingRelation="751" linkedAnnotations="748"/><semantic:LinkedAnnotationSet xmi:id="754" linkingRelation="760" linkedAnnotations="757"/><shared:ExternalReference xmi:id="34" namespace="GREC Concepts" ID="Protein_Complex"/><shared:ExternalReference xmi:id="52" namespace="GREC Concepts" ID="Transcription_Factor"/><shared:ExternalReference xmi:id="77" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="88" namespace="GREC Concepts" ID="Transcription_Factor"/><shared:ExternalReference xmi:id="99" namespace="GREC Concepts" ID="Protein_Complex"/><shared:ExternalReference xmi:id="110" namespace="GREC Concepts" ID="Promoter"/><shared:ExternalReference xmi:id="135" namespace="GREC Concepts" ID="Protein_Complex"/><shared:ExternalReference xmi:id="146" namespace="GREC Concepts" ID="Sub_Unit"/><shared:ExternalReference xmi:id="157" namespace="GREC Concepts" ID="Protein_Complex"/><shared:ExternalReference xmi:id="175" namespace="GREC Concepts" ID="Transcription_Factor"/><shared:ExternalReference xmi:id="200" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="218" namespace="GREC Concepts" ID="Transcription_Factor"/><shared:ExternalReference xmi:id="325" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="336" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="347" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="358" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="369" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="380" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="391" namespace="GREC" ID="Gene_Activation"/><shared:ExternalReference xmi:id="402" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="413" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="424" namespace="GREC" ID="Gene_Activation"/><shared:ExternalReference xmi:id="435" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="446" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="459" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="468" namespace="GREC Concepts" ID="Purpose"/><shared:ExternalReference xmi:id="482" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="491" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="500" namespace="GREC Concepts" ID="Condition"/><shared:ExternalReference xmi:id="513" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="522" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="536" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="545" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="554" namespace="GREC Concepts" ID="Purpose"/><shared:ExternalReference xmi:id="569" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="578" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="587" namespace="GREC Concepts" ID="Location"/><shared:ExternalReference xmi:id="596" namespace="GREC Concepts" ID="Condition"/><shared:ExternalReference xmi:id="609" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="618" namespace="GREC Concepts" ID="Descriptive-Theme"/><shared:ExternalReference xmi:id="631" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="640" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="652" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="666" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="675" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="684" namespace="GREC Concepts" ID="Descriptive-Agent"/><shared:ExternalReference xmi:id="696" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="710" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="719" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="728" namespace="GREC Concepts" ID="Instrument"/><shared:ExternalReference xmi:id="742" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="751" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="760" namespace="GREC Concepts" ID="Manner"/><semantic:EventAnnotation xmi:id="317" sofa="1" begin="58" end="66" externalReference="325" linkedAnnotationSets="449"/><semantic:EventAnnotation xmi:id="328" sofa="1" begin="103" end="113" externalReference="336" linkedAnnotationSets="471"/><semantic:EventAnnotation xmi:id="339" sofa="1" begin="202" end="212" externalReference="347" linkedAnnotationSets="503"/><semantic:EventAnnotation xmi:id="350" sofa="1" begin="262" end="270" externalReference="358" linkedAnnotationSets="525"/><semantic:EventAnnotation xmi:id="361" sofa="1" begin="369" end="377" externalReference="369" linkedAnnotationSets="557"/><semantic:EventAnnotation xmi:id="372" sofa="1" begin="489" end="497" externalReference="380" linkedAnnotationSets="599"/><semantic:EventAnnotation xmi:id="383" sofa="1" begin="786" end="794" externalReference="391" linkedAnnotationSets="621"/><semantic:EventAnnotation xmi:id="394" sofa="1" begin="795" end="805" externalReference="402" linkedAnnotationSets="643"/><semantic:EventAnnotation xmi:id="405" sofa="1" begin="920" end="924" externalReference="413" linkedAnnotationSets="655"/><semantic:EventAnnotation xmi:id="416" sofa="1" begin="953" end="963" externalReference="424" linkedAnnotationSets="687"/><semantic:EventAnnotation xmi:id="427" sofa="1" begin="972" end="980" externalReference="435" linkedAnnotationSets="699"/><semantic:EventAnnotation xmi:id="438" sofa="1" begin="1013" end="1024" externalReference="446" linkedAnnotationSets="731"/><comparable:IDArray xmi:id="763" array="766" idType="t"/><semantic2:NucleicAcids xmi:id="69" sofa="1" begin="216" end="242" externalReference="77"/><semantic2:NucleicAcids xmi:id="102" sofa="1" begin="380" end="449" externalReference="110"/><semantic2:NucleicAcids xmi:id="192" sofa="1" begin="981" end="997" externalReference="200"/><semantic2:Proteins xmi:id="26" sofa="1" begin="48" end="53" externalReference="34"/><semantic2:Proteins xmi:id="44" sofa="1" begin="117" end="121" externalReference="52"/><semantic2:Proteins xmi:id="80" sofa="1" begin="257" end="261" externalReference="88"/><semantic2:Proteins xmi:id="91" sofa="1" begin="358" end="363" externalReference="99"/><semantic2:Proteins xmi:id="127" sofa="1" begin="483" end="488" externalReference="135"/><semantic2:Proteins xmi:id="138" sofa="1" begin="498" end="545" externalReference="146"/><semantic2:Proteins xmi:id="149" sofa="1" begin="702" end="707" externalReference="157"/><semantic2:Proteins xmi:id="167" sofa="1" begin="889" end="919" externalReference="175"/><semantic2:Proteins xmi:id="210" sofa="1" begin="1030" end="1059" externalReference="218"/><semantic2:EventArgumentSpan xmi:id="37" sofa="1" begin="71" end="102"/><semantic2:EventArgumentSpan xmi:id="55" sofa="1" begin="122" end="130"/><semantic2:EventArgumentSpan xmi:id="62" sofa="1" begin="187" end="201"/><semantic2:EventArgumentSpan xmi:id="113" sofa="1" begin="450" end="472"/><semantic2:EventArgumentSpan xmi:id="120" sofa="1" begin="473" end="481"/><semantic2:EventArgumentSpan xmi:id="160" sofa="1" begin="809" end="844"/><semantic2:EventArgumentSpan xmi:id="178" sofa="1" begin="925" end="933"/><semantic2:EventArgumentSpan xmi:id="185" sofa="1" begin="937" end="952"/><semantic2:EventArgumentSpan xmi:id="203" sofa="1" begin="1001" end="1012"/><cas:View sofa="1" members="449 456 465 471 479 488 497 503 510 519 525 533 542 551 557 566 575 584 593 599 606 615 621 628 637 643 649 655 663 672 681 687 693 699 707 716 725 731 739 748 757 766 8 21 13 453 462 476 485 494 507 516 530 539 548 563 572 581 590 603 612 625 634 646 660 669 678 690 704 713 722 736 745 754 34 52 77 88 99 110 135 146 157 175 200 218 325 336 347 358 369 380 391 402 413 424 435 446 459 468 482 491 500 513 522 536 545 554 569 578 587 596 609 618 631 640 652 666 675 684 696 710 719 728 742 751 760 317 328 339 350 361 372 383 394 405 416 427 438 763 69 102 192 26 44 80 91 127 138 149 167 210 37 55 62 113 120 160 178 185 203"/></xmi:XMI>