<?xml version="1.0" encoding="UTF-8"?><xmi:XMI xmlns:pos="http:///org/u_compare/shared/label/penn/pos.ecore" xmlns:grammatical="http:///org/u_compare/shared/label/penn/function/grammatical.ecore" xmlns:general="http:///org/u_compare/shared/label/penn/pos/general.ecore" xmlns:cas="http:///uima/cas.ecore" xmlns:stanford="http:///org/u_compare/shared/label/stanford.ecore" xmlns:semantic2="http:///uk/ac/nactem/semantic.ecore" xmlns:bioie="http:///org/u_compare/shared/label/penn/pos/bioie.ecore" xmlns:function="http:///org/u_compare/shared/label/penn/function.ecore" xmlns:tcas="http:///uima/tcas.ecore" xmlns:bio="http:///org/u_compare/shared/semantic/bio.ecore" xmlns:syntactic="http:///org/u_compare/shared/syntactic.ecore" xmlns:comparable="http:///org/u_compare/shared/comparable.ecore" xmlns:examples="http:///org/apache/uima/examples.ecore" xmlns:label="http:///org/u_compare/shared/label.ecore" xmlns:xmi="http://www.omg.org/XMI" xmlns:general2="http:///org/u_compare/shared/label/penn/bracket/general.ecore" xmlns:shared="http:///org/u_compare/shared.ecore" xmlns:fragment="http:///org/u_compare/shared/document/fragment.ecore" xmlns:document="http:///org/u_compare/shared/document.ecore" xmlns:bracket="http:///org/u_compare/shared/label/penn/bracket.ecore" xmlns:text="http:///org/u_compare/shared/label/penn/function/text.ecore" xmlns:structure="http:///org/u_compare/shared/document/structure.ecore" xmlns:text2="http:///org/u_compare/shared/document/text.ecore" xmlns:release="http:///org/u_compare/shared/label/penn/pos/release.ecore" xmlns:semantic="http:///org/u_compare/shared/semantic.ecore" xmlns:nontext="http:///org/u_compare/shared/document/nontext.ecore" xmlns:conll="http:///org/u_compare/shared/label/conll.ecore" xmlns:chemical="http:///org/u_compare/shared/semantic/chemical.ecore" xmlns:semantic3="http:///org/u_compare/shared/label/penn/function/semantic.ecore" xmlns:release2="http:///org/u_compare/shared/label/penn/bracket/release.ecore" xmlns:coindex="http:///org/u_compare/shared/label/penn/coindex.ecore" xmi:version="2.0"><cas:NULL xmi:id="0"/><cas:Sofa xmi:id="1" sofaNum="1" sofaID="_InitialView" mimeType="text" sofaString="Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. &#10;Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We identified an associated 21 kd protein partner, Bax, that has extensive amino acid homology with Bcl-2, focused within highly conserved domains I and II. Bax is encoded by six exons and demonstrates a complex pattern of alternative RNA splicing that predicts a 21 kd membrane (alpha) and two forms of cytosolic protein (beta and gamma). Bax homodimerizes and forms heterodimers with Bcl-2 in vivo. Overexpressed Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3-dependent cell line. Overexpressed Bax also counters the death repressor activity of Bcl-2. These data suggest a model in which the ratio of Bcl-2 to Bax determines survival or death following an apoptotic stimulus. "/><cas:FSArray xmi:id="67" elements="71 80"/><cas:FSArray xmi:id="74" elements="37"/><cas:FSArray xmi:id="83" elements="26"/><cas:FSArray xmi:id="92" elements="0 26 37 0"/><tcas:DocumentAnnotation xmi:id="8" sofa="1" begin="0" end="985" language="x-unspecified"/><tcas:DocumentAnnotation xmi:id="21" sofa="1" begin="0" end="985"/><examples:SourceDocumentInformation xmi:id="13" sofa="1" begin="0" end="985" uri="/8358790.txt" offsetInSource="0" documentSize="985" lastSegment="true"/><semantic:LinkedAnnotationSet xmi:id="71" linkingRelation="77" linkedAnnotations="74"/><semantic:LinkedAnnotationSet xmi:id="80" linkingRelation="86" linkedAnnotations="83"/><shared:ExternalReference xmi:id="34" namespace="GREC Concepts" ID="Protein"/><shared:ExternalReference xmi:id="45" namespace="GREC Concepts" ID="DNA"/><shared:ExternalReference xmi:id="64" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="77" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="86" namespace="GREC Concepts" ID="Theme"/><semantic:EventAnnotation xmi:id="56" sofa="1" begin="443" end="450" externalReference="64" linkedAnnotationSets="67"/><comparable:IDArray xmi:id="89" array="92" idType="t"/><semantic2:NucleicAcids xmi:id="37" sofa="1" begin="454" end="463" externalReference="45"/><semantic2:Proteins xmi:id="26" sofa="1" begin="436" end="439" externalReference="34"/><cas:View sofa="1" members="67 74 83 92 8 21 13 71 80 34 45 64 77 86 56 89 37 26"/></xmi:XMI>