<?xml version="1.0" encoding="UTF-8"?><xmi:XMI xmlns:pos="http:///org/u_compare/shared/label/penn/pos.ecore" xmlns:grammatical="http:///org/u_compare/shared/label/penn/function/grammatical.ecore" xmlns:general="http:///org/u_compare/shared/label/penn/pos/general.ecore" xmlns:cas="http:///uima/cas.ecore" xmlns:stanford="http:///org/u_compare/shared/label/stanford.ecore" xmlns:semantic2="http:///uk/ac/nactem/semantic.ecore" xmlns:bioie="http:///org/u_compare/shared/label/penn/pos/bioie.ecore" xmlns:function="http:///org/u_compare/shared/label/penn/function.ecore" xmlns:tcas="http:///uima/tcas.ecore" xmlns:bio="http:///org/u_compare/shared/semantic/bio.ecore" xmlns:syntactic="http:///org/u_compare/shared/syntactic.ecore" xmlns:comparable="http:///org/u_compare/shared/comparable.ecore" xmlns:examples="http:///org/apache/uima/examples.ecore" xmlns:label="http:///org/u_compare/shared/label.ecore" xmlns:xmi="http://www.omg.org/XMI" xmlns:general2="http:///org/u_compare/shared/label/penn/bracket/general.ecore" xmlns:shared="http:///org/u_compare/shared.ecore" xmlns:fragment="http:///org/u_compare/shared/document/fragment.ecore" xmlns:document="http:///org/u_compare/shared/document.ecore" xmlns:bracket="http:///org/u_compare/shared/label/penn/bracket.ecore" xmlns:text="http:///org/u_compare/shared/label/penn/function/text.ecore" xmlns:structure="http:///org/u_compare/shared/document/structure.ecore" xmlns:text2="http:///org/u_compare/shared/document/text.ecore" xmlns:release="http:///org/u_compare/shared/label/penn/pos/release.ecore" xmlns:semantic="http:///org/u_compare/shared/semantic.ecore" xmlns:nontext="http:///org/u_compare/shared/document/nontext.ecore" xmlns:conll="http:///org/u_compare/shared/label/conll.ecore" xmlns:chemical="http:///org/u_compare/shared/semantic/chemical.ecore" xmlns:semantic3="http:///org/u_compare/shared/label/penn/function/semantic.ecore" xmlns:release2="http:///org/u_compare/shared/label/penn/bracket/release.ecore" xmlns:coindex="http:///org/u_compare/shared/label/penn/coindex.ecore" xmi:version="2.0"><cas:NULL xmi:id="0"/><cas:Sofa xmi:id="1" sofaNum="1" sofaID="_InitialView" mimeType="text" sofaString="Transcriptional control mediated by the ArcA two-component response regulator protein of Escherichia coli: characterization of DNA binding at target promoters. &#10;ArcA protein bearing an amino-terminal, oligohistidine extension has been purified, and its DNA binding activity has been characterized with or without prior incubation with carbamoyl phosphate. Electrophoretic mobility shift assays and DNase I protection assays indicate that where the phosphorylated form of the ArcA protein (ArcA-P) is expected to act as a transcriptional repressor (e.g., of lctPRD and gltA-sdhCDAB), the effect is likely to be mediated by sequestration of cis-controlling transcriptional regulatory elements. In contrast, in the case of cydAB, for which ArcA-P is expected to function as a transcriptional activator, two discrete binding sites have been identified upstream of a known promoter, and activation from these sites is likely to be mediated by a mechanism typical of the type I class of prokaryotic transcriptional activators. An additional ArcA-P binding site has also been located downstream of the known promoter, and a distinct role for this site in the regulation of the cydAB operon during anoxic growth transitions is suggested. These results are discussed within the framework of an overall model of signaling by the Arc two-component signal transduction system in response to changes in aerobiosis. "/><cas:FSArray xmi:id="197" elements="201 210"/><cas:FSArray xmi:id="204" elements="33"/><cas:FSArray xmi:id="213" elements="26"/><cas:FSArray xmi:id="219" elements="223 232"/><cas:FSArray xmi:id="226" elements="44"/><cas:FSArray xmi:id="235" elements="55"/><cas:FSArray xmi:id="241" elements="245 254"/><cas:FSArray xmi:id="248" elements="175"/><cas:FSArray xmi:id="257" elements="66"/><cas:FSArray xmi:id="263" elements="266"/><cas:FSArray xmi:id="269" elements="73"/><cas:FSArray xmi:id="275" elements="279 288"/><cas:FSArray xmi:id="282" elements="80"/><cas:FSArray xmi:id="291" elements="91"/><cas:FSArray xmi:id="300" elements="0 26 33 44 55 66 73 80 91 0 0 0 0 0"/><tcas:DocumentAnnotation xmi:id="8" sofa="1" begin="0" end="1402" language="x-unspecified"/><tcas:DocumentAnnotation xmi:id="21" sofa="1" begin="0" end="1402"/><examples:SourceDocumentInformation xmi:id="13" sofa="1" begin="0" end="1402" uri="/8892825.txt" offsetInSource="0" documentSize="1402" lastSegment="true"/><semantic:LinkedAnnotationSet xmi:id="201" linkingRelation="207" linkedAnnotations="204"/><semantic:LinkedAnnotationSet xmi:id="210" linkingRelation="216" linkedAnnotations="213"/><semantic:LinkedAnnotationSet xmi:id="223" linkingRelation="229" linkedAnnotations="226"/><semantic:LinkedAnnotationSet xmi:id="232" linkingRelation="238" linkedAnnotations="235"/><semantic:LinkedAnnotationSet xmi:id="245" linkingRelation="251" linkedAnnotations="248"/><semantic:LinkedAnnotationSet xmi:id="254" linkingRelation="260" linkedAnnotations="257"/><semantic:LinkedAnnotationSet xmi:id="266" linkingRelation="272" linkedAnnotations="269"/><semantic:LinkedAnnotationSet xmi:id="279" linkingRelation="285" linkedAnnotations="282"/><semantic:LinkedAnnotationSet xmi:id="288" linkingRelation="294" linkedAnnotations="291"/><shared:ExternalReference xmi:id="41" namespace="GREC Concepts" ID="Protein"/><shared:ExternalReference xmi:id="52" namespace="GREC Concepts" ID="Protein"/><shared:ExternalReference xmi:id="63" namespace="GREC Concepts" ID="Repressor"/><shared:ExternalReference xmi:id="88" namespace="GREC Concepts" ID="Protein"/><shared:ExternalReference xmi:id="99" namespace="GREC Concepts" ID="Activator"/><shared:ExternalReference xmi:id="150" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="161" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="172" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="183" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="194" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="207" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="216" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="229" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="238" namespace="GREC Concepts" ID="Descriptive-Theme"/><shared:ExternalReference xmi:id="251" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="260" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="272" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="285" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="294" namespace="GREC Concepts" ID="Descriptive-Theme"/><semantic:EventAnnotation xmi:id="142" sofa="1" begin="24" end="32" externalReference="150" linkedAnnotationSets="197"/><semantic:EventAnnotation xmi:id="153" sofa="1" begin="512" end="515" externalReference="161" linkedAnnotationSets="219"/><semantic:EventAnnotation xmi:id="164" sofa="1" begin="610" end="618" externalReference="172" linkedAnnotationSets="241"/><semantic:EventAnnotation xmi:id="175" sofa="1" begin="622" end="635" externalReference="183" linkedAnnotationSets="263"/><semantic:EventAnnotation xmi:id="186" sofa="1" begin="759" end="767" externalReference="194" linkedAnnotationSets="275"/><comparable:IDArray xmi:id="297" array="300" idType="t"/><semantic2:Proteins xmi:id="33" sofa="1" begin="36" end="85" externalReference="41"/><semantic2:Proteins xmi:id="44" sofa="1" begin="489" end="495" externalReference="52"/><semantic2:Proteins xmi:id="55" sofa="1" begin="519" end="546" externalReference="63"/><semantic2:Proteins xmi:id="80" sofa="1" begin="737" end="743" externalReference="88"/><semantic2:Proteins xmi:id="91" sofa="1" begin="771" end="798" externalReference="99"/><semantic2:EventArgumentSpan xmi:id="26" sofa="1" begin="0" end="23"/><semantic2:EventArgumentSpan xmi:id="66" sofa="1" begin="583" end="593"/><semantic2:EventArgumentSpan xmi:id="73" sofa="1" begin="639" end="690"/><cas:View sofa="1" members="197 204 213 219 226 235 241 248 257 263 269 275 282 291 300 8 21 13 201 210 223 232 245 254 266 279 288 41 52 63 88 99 150 161 172 183 194 207 216 229 238 251 260 272 285 294 142 153 164 175 186 297 33 44 55 80 91 26 66 73"/></xmi:XMI>