<?xml version="1.0" encoding="UTF-8"?><xmi:XMI xmlns:pos="http:///org/u_compare/shared/label/penn/pos.ecore" xmlns:grammatical="http:///org/u_compare/shared/label/penn/function/grammatical.ecore" xmlns:general="http:///org/u_compare/shared/label/penn/pos/general.ecore" xmlns:cas="http:///uima/cas.ecore" xmlns:stanford="http:///org/u_compare/shared/label/stanford.ecore" xmlns:semantic2="http:///uk/ac/nactem/semantic.ecore" xmlns:bioie="http:///org/u_compare/shared/label/penn/pos/bioie.ecore" xmlns:function="http:///org/u_compare/shared/label/penn/function.ecore" xmlns:tcas="http:///uima/tcas.ecore" xmlns:bio="http:///org/u_compare/shared/semantic/bio.ecore" xmlns:syntactic="http:///org/u_compare/shared/syntactic.ecore" xmlns:comparable="http:///org/u_compare/shared/comparable.ecore" xmlns:examples="http:///org/apache/uima/examples.ecore" xmlns:label="http:///org/u_compare/shared/label.ecore" xmlns:xmi="http://www.omg.org/XMI" xmlns:general2="http:///org/u_compare/shared/label/penn/bracket/general.ecore" xmlns:shared="http:///org/u_compare/shared.ecore" xmlns:fragment="http:///org/u_compare/shared/document/fragment.ecore" xmlns:document="http:///org/u_compare/shared/document.ecore" xmlns:bracket="http:///org/u_compare/shared/label/penn/bracket.ecore" xmlns:text="http:///org/u_compare/shared/label/penn/function/text.ecore" xmlns:structure="http:///org/u_compare/shared/document/structure.ecore" xmlns:text2="http:///org/u_compare/shared/document/text.ecore" xmlns:release="http:///org/u_compare/shared/label/penn/pos/release.ecore" xmlns:semantic="http:///org/u_compare/shared/semantic.ecore" xmlns:nontext="http:///org/u_compare/shared/document/nontext.ecore" xmlns:conll="http:///org/u_compare/shared/label/conll.ecore" xmlns:chemical="http:///org/u_compare/shared/semantic/chemical.ecore" xmlns:semantic3="http:///org/u_compare/shared/label/penn/function/semantic.ecore" xmlns:release2="http:///org/u_compare/shared/label/penn/bracket/release.ecore" xmlns:coindex="http:///org/u_compare/shared/label/penn/coindex.ecore" xmi:version="2.0"><cas:NULL xmi:id="0"/><cas:Sofa xmi:id="1" sofaNum="1" sofaID="_InitialView" mimeType="text" sofaString="DNA sequence and characterization of GcvA, a LysR family regulatory protein for the Escherichia coli glycine cleavage enzyme system. &#10;The gene encoding GcvA, the trans-acting regulatory protein for the Escherichia coli glycine cleavage enzyme system, has been sequenced. The gcvA locus contains an open reading frame of 930 nucleotides that could encode a protein with a molecular mass of 34.4 kDa, consistent with the results of minicell analysis indicating that GcvA is a polypeptide of approximately 33 kDa. The deduced amino acid sequence of GcvA revealed that this protein shares similarity with the LysR family of activator proteins. The transcription start site was found to be 72 bp upstream of the presumed translation start site. A chromosomal deletion of gcvA resulted in the inability of cells to activate the expression of a gcvT-lacZ gene fusion when grown in the presence of glycine and an inability to repress gcvT-lacZ expression when grown in the presence of inosine. The regulation of gcvA was examined by constructing a gcvA-lacZ gene fusion in which beta-galactosidase synthesis is under the control of the gcvA regulatory region. Although gcvA expression appears to be autogenously regulated over a two- to threefold range, it is neither induced by glycine nor repressed by inosine. "/><cas:FSArray xmi:id="403" elements="407 416"/><cas:FSArray xmi:id="410" elements="26"/><cas:FSArray xmi:id="419" elements="37"/><cas:FSArray xmi:id="425" elements="429 438"/><cas:FSArray xmi:id="432" elements="48"/><cas:FSArray xmi:id="441" elements="59"/><cas:FSArray xmi:id="447" elements="452 461 470"/><cas:FSArray xmi:id="455" elements="70"/><cas:FSArray xmi:id="464" elements="80"/><cas:FSArray xmi:id="473" elements="98"/><cas:FSArray xmi:id="479" elements="482"/><cas:FSArray xmi:id="485" elements="87"/><cas:FSArray xmi:id="491" elements="495 504"/><cas:FSArray xmi:id="498" elements="123"/><cas:FSArray xmi:id="507" elements="130"/><cas:FSArray xmi:id="513" elements="516"/><cas:FSArray xmi:id="519" elements="112"/><cas:FSArray xmi:id="525" elements="528"/><cas:FSArray xmi:id="531" elements="144"/><cas:FSArray xmi:id="537" elements="540"/><cas:FSArray xmi:id="543" elements="155"/><cas:FSArray xmi:id="549" elements="553 562"/><cas:FSArray xmi:id="556" elements="166"/><cas:FSArray xmi:id="565" elements="173"/><cas:FSArray xmi:id="571" elements="575 584"/><cas:FSArray xmi:id="578" elements="180"/><cas:FSArray xmi:id="587" elements="166"/><cas:FSArray xmi:id="593" elements="597 606"/><cas:FSArray xmi:id="600" elements="187"/><cas:FSArray xmi:id="609" elements="166"/><cas:FSArray xmi:id="618" elements="0 26 37 48 59 70 80 87 98 105 112 123 130 137 144 155 166 173 180 187 0 0 0 0 0 0 0 0 0 0 0"/><tcas:DocumentAnnotation xmi:id="8" sofa="1" begin="0" end="1305" language="x-unspecified"/><tcas:DocumentAnnotation xmi:id="21" sofa="1" begin="0" end="1305"/><examples:SourceDocumentInformation xmi:id="13" sofa="1" begin="0" end="1305" uri="/8188587.txt" offsetInSource="0" documentSize="1305" lastSegment="true"/><semantic:LinkedAnnotationSet xmi:id="407" linkingRelation="413" linkedAnnotations="410"/><semantic:LinkedAnnotationSet xmi:id="416" linkingRelation="422" linkedAnnotations="419"/><semantic:LinkedAnnotationSet xmi:id="429" linkingRelation="435" linkedAnnotations="432"/><semantic:LinkedAnnotationSet xmi:id="438" linkingRelation="444" linkedAnnotations="441"/><semantic:LinkedAnnotationSet xmi:id="452" linkingRelation="458" linkedAnnotations="455"/><semantic:LinkedAnnotationSet xmi:id="461" linkingRelation="467" linkedAnnotations="464"/><semantic:LinkedAnnotationSet xmi:id="470" linkingRelation="476" linkedAnnotations="473"/><semantic:LinkedAnnotationSet xmi:id="482" linkingRelation="488" linkedAnnotations="485"/><semantic:LinkedAnnotationSet xmi:id="495" linkingRelation="501" linkedAnnotations="498"/><semantic:LinkedAnnotationSet xmi:id="504" linkingRelation="510" linkedAnnotations="507"/><semantic:LinkedAnnotationSet xmi:id="516" linkingRelation="522" linkedAnnotations="519"/><semantic:LinkedAnnotationSet xmi:id="528" linkingRelation="534" linkedAnnotations="531"/><semantic:LinkedAnnotationSet xmi:id="540" linkingRelation="546" linkedAnnotations="543"/><semantic:LinkedAnnotationSet xmi:id="553" linkingRelation="559" linkedAnnotations="556"/><semantic:LinkedAnnotationSet xmi:id="562" linkingRelation="568" linkedAnnotations="565"/><semantic:LinkedAnnotationSet xmi:id="575" linkingRelation="581" linkedAnnotations="578"/><semantic:LinkedAnnotationSet xmi:id="584" linkingRelation="590" linkedAnnotations="587"/><semantic:LinkedAnnotationSet xmi:id="597" linkingRelation="603" linkedAnnotations="600"/><semantic:LinkedAnnotationSet xmi:id="606" linkingRelation="612" linkedAnnotations="609"/><shared:ExternalReference xmi:id="34" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="45" namespace="GREC Concepts" ID="Regulator"/><shared:ExternalReference xmi:id="56" namespace="GREC Concepts" ID="Locus"/><shared:ExternalReference xmi:id="67" namespace="GREC Concepts" ID="Protein"/><shared:ExternalReference xmi:id="77" namespace="GREC Concepts" ID="Deletion"/><shared:ExternalReference xmi:id="95" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="120" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="152" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="163" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="290" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="301" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="312" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="323" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="334" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="345" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="356" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="367" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="378" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="389" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="400" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="413" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="422" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="435" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="444" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="458" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="467" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="476" namespace="GREC Concepts" ID="Condition"/><shared:ExternalReference xmi:id="488" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="501" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="510" namespace="GREC Concepts" ID="Condition"/><shared:ExternalReference xmi:id="522" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="534" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="546" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="559" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="568" namespace="GREC Concepts" ID="Rate"/><shared:ExternalReference xmi:id="581" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="590" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="603" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="612" namespace="GREC Concepts" ID="Theme"/><semantic:EventAnnotation xmi:id="282" sofa="1" begin="143" end="151" externalReference="290" linkedAnnotationSets="403"/><semantic:EventAnnotation xmi:id="293" sofa="1" begin="347" end="353" externalReference="301" linkedAnnotationSets="425"/><semantic:EventAnnotation xmi:id="304" sofa="1" begin="809" end="817" externalReference="312" linkedAnnotationSets="447"/><semantic:EventAnnotation xmi:id="315" sofa="1" begin="822" end="832" externalReference="323" linkedAnnotationSets="479"/><semantic:EventAnnotation xmi:id="326" sofa="1" begin="918" end="925" externalReference="334" linkedAnnotationSets="491"/><semantic:EventAnnotation xmi:id="337" sofa="1" begin="936" end="946" externalReference="345" linkedAnnotationSets="513"/><semantic:EventAnnotation xmi:id="348" sofa="1" begin="990" end="1000" externalReference="356" linkedAnnotationSets="525"/><semantic:EventAnnotation xmi:id="359" sofa="1" begin="1166" end="1176" externalReference="367" linkedAnnotationSets="537"/><semantic:EventAnnotation xmi:id="370" sofa="1" begin="1204" end="1213" externalReference="378" linkedAnnotationSets="549"/><semantic:EventAnnotation xmi:id="381" sofa="1" begin="1260" end="1267" externalReference="389" linkedAnnotationSets="571"/><semantic:EventAnnotation xmi:id="392" sofa="1" begin="1283" end="1292" externalReference="400" linkedAnnotationSets="593"/><comparable:IDArray xmi:id="615" array="618" idType="t"/><semantic2:NucleicAcids xmi:id="26" sofa="1" begin="134" end="142" externalReference="34"/><semantic2:NucleicAcids xmi:id="48" sofa="1" begin="271" end="285" externalReference="56"/><semantic2:NucleicAcids xmi:id="87" sofa="1" begin="836" end="859" externalReference="95"/><semantic2:NucleicAcids xmi:id="112" sofa="1" begin="926" end="935" externalReference="120"/><semantic2:NucleicAcids xmi:id="144" sofa="1" begin="1004" end="1008" externalReference="152"/><semantic2:NucleicAcids xmi:id="155" sofa="1" begin="1161" end="1165" externalReference="163"/><semantic2:Proteins xmi:id="37" sofa="1" begin="152" end="156" externalReference="45"/><semantic2:Proteins xmi:id="59" sofa="1" begin="354" end="363" externalReference="67"/><semantic2:Processes xmi:id="70" sofa="1" begin="740" end="762" externalReference="77"/><semantic2:EventArgumentSpan xmi:id="80" sofa="1" begin="818" end="832"/><semantic2:EventArgumentSpan xmi:id="98" sofa="1" begin="865" end="897"/><semantic2:EventArgumentSpan xmi:id="105" sofa="1" begin="890" end="897"/><semantic2:EventArgumentSpan xmi:id="123" sofa="1" begin="926" end="946"/><semantic2:EventArgumentSpan xmi:id="130" sofa="1" begin="952" end="984"/><semantic2:EventArgumentSpan xmi:id="137" sofa="1" begin="977" end="984"/><semantic2:EventArgumentSpan xmi:id="166" sofa="1" begin="1161" end="1176"/><semantic2:EventArgumentSpan xmi:id="173" sofa="1" begin="1219" end="1244"/><semantic2:EventArgumentSpan xmi:id="180" sofa="1" begin="1271" end="1278"/><semantic2:EventArgumentSpan xmi:id="187" sofa="1" begin="1296" end="1303"/><cas:View sofa="1" members="403 410 419 425 432 441 447 455 464 473 479 485 491 498 507 513 519 525 531 537 543 549 556 565 571 578 587 593 600 609 618 8 21 13 407 416 429 438 452 461 470 482 495 504 516 528 540 553 562 575 584 597 606 34 45 56 67 77 95 120 152 163 290 301 312 323 334 345 356 367 378 389 400 413 422 435 444 458 467 476 488 501 510 522 534 546 559 568 581 590 603 612 282 293 304 315 326 337 348 359 370 381 392 615 26 48 87 112 144 155 37 59 70 80 98 105 123 130 137 166 173 180 187"/></xmi:XMI>