<?xml version="1.0" encoding="UTF-8"?><xmi:XMI xmlns:pos="http:///org/u_compare/shared/label/penn/pos.ecore" xmlns:grammatical="http:///org/u_compare/shared/label/penn/function/grammatical.ecore" xmlns:general="http:///org/u_compare/shared/label/penn/pos/general.ecore" xmlns:cas="http:///uima/cas.ecore" xmlns:stanford="http:///org/u_compare/shared/label/stanford.ecore" xmlns:semantic2="http:///uk/ac/nactem/semantic.ecore" xmlns:bioie="http:///org/u_compare/shared/label/penn/pos/bioie.ecore" xmlns:function="http:///org/u_compare/shared/label/penn/function.ecore" xmlns:tcas="http:///uima/tcas.ecore" xmlns:bio="http:///org/u_compare/shared/semantic/bio.ecore" xmlns:syntactic="http:///org/u_compare/shared/syntactic.ecore" xmlns:comparable="http:///org/u_compare/shared/comparable.ecore" xmlns:examples="http:///org/apache/uima/examples.ecore" xmlns:label="http:///org/u_compare/shared/label.ecore" xmlns:xmi="http://www.omg.org/XMI" xmlns:general2="http:///org/u_compare/shared/label/penn/bracket/general.ecore" xmlns:shared="http:///org/u_compare/shared.ecore" xmlns:fragment="http:///org/u_compare/shared/document/fragment.ecore" xmlns:document="http:///org/u_compare/shared/document.ecore" xmlns:bracket="http:///org/u_compare/shared/label/penn/bracket.ecore" xmlns:text="http:///org/u_compare/shared/label/penn/function/text.ecore" xmlns:structure="http:///org/u_compare/shared/document/structure.ecore" xmlns:text2="http:///org/u_compare/shared/document/text.ecore" xmlns:release="http:///org/u_compare/shared/label/penn/pos/release.ecore" xmlns:semantic="http:///org/u_compare/shared/semantic.ecore" xmlns:nontext="http:///org/u_compare/shared/document/nontext.ecore" xmlns:conll="http:///org/u_compare/shared/label/conll.ecore" xmlns:chemical="http:///org/u_compare/shared/semantic/chemical.ecore" xmlns:semantic3="http:///org/u_compare/shared/label/penn/function/semantic.ecore" xmlns:release2="http:///org/u_compare/shared/label/penn/bracket/release.ecore" xmlns:coindex="http:///org/u_compare/shared/label/penn/coindex.ecore" xmi:version="2.0"><cas:NULL xmi:id="0"/><cas:Sofa xmi:id="1" sofaNum="1" sofaID="_InitialView" mimeType="text" sofaString="The leucine-responsive regulatory protein of Escherichia coli negatively regulates transcription of ompC and micF and positively regulates translation of ompF. &#10;The two major porins of Escherichia coli K-12 strains, OmpC and OmpF, are inversely regulated with respect to one another. The expression of OmpC and OmpF has been shown to be influenced by the leucine-responsive regulatory protein (Lrp): two-dimensional gel electrophoresis of proteins from strains with and strains without a functional Lrp protein revealed that OmpC expression is increased in an lrp strain, while OmpF expression is decreased. In agreement with these findings, we now present evidence that transcriptional (operon) fusions of lacZ+ to ompC and micF are negatively regulated by Lrp. Lrp binds specifically to the intergenic region between micF and ompC, as indicated by mobility shift assays and by DNase I footprinting. The expression of an ompF'-lacZ+ gene (translational) fusion is increased 3.7-fold in an lrp+ background compared with an lrp background, but expression of an ompF-lacZ+ operon fusion is not. Studies of in vivo expression of the outer membrane porins during growth on glucose minimal medium showed that the OmpF/OmpC ratio is higher in lrp+ strains than it is in isogenic lrp strains. The effect of Lrp was not seen in a strain containing a deletion of micF. Our studies suggest that the positive effect of Lrp on OmpF expression stems from a negative effect of Lrp on the expression of micF, an antisense RNA that inhibits ompF translation. "/><cas:FSArray xmi:id="784" elements="789 798 807"/><cas:FSArray xmi:id="792" elements="26"/><cas:FSArray xmi:id="801" elements="553"/><cas:FSArray xmi:id="810" elements="37"/><cas:FSArray xmi:id="816" elements="819"/><cas:FSArray xmi:id="822" elements="44"/><cas:FSArray xmi:id="828" elements="833 842 851"/><cas:FSArray xmi:id="836" elements="26"/><cas:FSArray xmi:id="845" elements="62"/><cas:FSArray xmi:id="854" elements="55"/><cas:FSArray xmi:id="860" elements="864 873"/><cas:FSArray xmi:id="867" elements="69"/><cas:FSArray xmi:id="876" elements="80"/><cas:FSArray xmi:id="882" elements="885"/><cas:FSArray xmi:id="888" elements="87"/><cas:FSArray xmi:id="894" elements="898 907"/><cas:FSArray xmi:id="901" elements="98"/><cas:FSArray xmi:id="910" elements="586"/><cas:FSArray xmi:id="916" elements="919"/><cas:FSArray xmi:id="922" elements="109"/><cas:FSArray xmi:id="928" elements="932 941"/><cas:FSArray xmi:id="935" elements="608"/><cas:FSArray xmi:id="944" elements="120"/><cas:FSArray xmi:id="950" elements="953"/><cas:FSArray xmi:id="956" elements="138"/><cas:FSArray xmi:id="962" elements="966 975"/><cas:FSArray xmi:id="969" elements="630"/><cas:FSArray xmi:id="978" elements="120"/><cas:FSArray xmi:id="984" elements="989 998 1007"/><cas:FSArray xmi:id="992" elements="167"/><cas:FSArray xmi:id="1001" elements="149"/><cas:FSArray xmi:id="1010" elements="160"/><cas:FSArray xmi:id="1016" elements="1021 1030 1039"/><cas:FSArray xmi:id="1024" elements="178"/><cas:FSArray xmi:id="1033" elements="189"/><cas:FSArray xmi:id="1042" elements="196"/><cas:FSArray xmi:id="1048" elements="1051"/><cas:FSArray xmi:id="1054" elements="218"/><cas:FSArray xmi:id="1060" elements="1065 1074 1083"/><cas:FSArray xmi:id="1068" elements="674"/><cas:FSArray xmi:id="1077" elements="232"/><cas:FSArray xmi:id="1086" elements="225"/><cas:FSArray xmi:id="1092" elements="1095"/><cas:FSArray xmi:id="1098" elements="250"/><cas:FSArray xmi:id="1104" elements="1109 1118 1127"/><cas:FSArray xmi:id="1112" elements="268"/><cas:FSArray xmi:id="1121" elements="261"/><cas:FSArray xmi:id="1130" elements="279"/><cas:FSArray xmi:id="1136" elements="1140 1149"/><cas:FSArray xmi:id="1143" elements="286"/><cas:FSArray xmi:id="1152" elements="729"/><cas:FSArray xmi:id="1158" elements="1161"/><cas:FSArray xmi:id="1164" elements="297"/><cas:FSArray xmi:id="1170" elements="1175 1184 1193"/><cas:FSArray xmi:id="1178" elements="315"/><cas:FSArray xmi:id="1187" elements="751"/><cas:FSArray xmi:id="1196" elements="308"/><cas:FSArray xmi:id="1202" elements="1205"/><cas:FSArray xmi:id="1208" elements="326"/><cas:FSArray xmi:id="1214" elements="1219 1228 1237"/><cas:FSArray xmi:id="1222" elements="344"/><cas:FSArray xmi:id="1231" elements="773"/><cas:FSArray xmi:id="1240" elements="337"/><cas:FSArray xmi:id="1246" elements="1249"/><cas:FSArray xmi:id="1252" elements="355"/><cas:FSArray xmi:id="1261" elements="0 26 37 44 55 62 69 80 87 98 109 120 127 138 149 160 167 178 189 196 207 218 225 232 239 250 261 268 279 286 297 308 315 326 337 344 355 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0"/><tcas:DocumentAnnotation xmi:id="8" sofa="1" begin="0" end="1543" language="x-unspecified"/><tcas:DocumentAnnotation xmi:id="21" sofa="1" begin="0" end="1543"/><examples:SourceDocumentInformation xmi:id="13" sofa="1" begin="0" end="1543" uri="/8002608.txt" offsetInSource="0" documentSize="1543" lastSegment="true"/><semantic:LinkedAnnotationSet xmi:id="789" linkingRelation="795" linkedAnnotations="792"/><semantic:LinkedAnnotationSet xmi:id="798" linkingRelation="804" linkedAnnotations="801"/><semantic:LinkedAnnotationSet xmi:id="807" linkingRelation="813" linkedAnnotations="810"/><semantic:LinkedAnnotationSet xmi:id="819" linkingRelation="825" linkedAnnotations="822"/><semantic:LinkedAnnotationSet xmi:id="833" linkingRelation="839" linkedAnnotations="836"/><semantic:LinkedAnnotationSet xmi:id="842" linkingRelation="848" linkedAnnotations="845"/><semantic:LinkedAnnotationSet xmi:id="851" linkingRelation="857" linkedAnnotations="854"/><semantic:LinkedAnnotationSet xmi:id="864" linkingRelation="870" linkedAnnotations="867"/><semantic:LinkedAnnotationSet xmi:id="873" linkingRelation="879" linkedAnnotations="876"/><semantic:LinkedAnnotationSet xmi:id="885" linkingRelation="891" linkedAnnotations="888"/><semantic:LinkedAnnotationSet xmi:id="898" linkingRelation="904" linkedAnnotations="901"/><semantic:LinkedAnnotationSet xmi:id="907" linkingRelation="913" linkedAnnotations="910"/><semantic:LinkedAnnotationSet xmi:id="919" linkingRelation="925" linkedAnnotations="922"/><semantic:LinkedAnnotationSet xmi:id="932" linkingRelation="938" linkedAnnotations="935"/><semantic:LinkedAnnotationSet xmi:id="941" linkingRelation="947" linkedAnnotations="944"/><semantic:LinkedAnnotationSet xmi:id="953" linkingRelation="959" linkedAnnotations="956"/><semantic:LinkedAnnotationSet xmi:id="966" linkingRelation="972" linkedAnnotations="969"/><semantic:LinkedAnnotationSet xmi:id="975" linkingRelation="981" linkedAnnotations="978"/><semantic:LinkedAnnotationSet xmi:id="989" linkingRelation="995" linkedAnnotations="992"/><semantic:LinkedAnnotationSet xmi:id="998" linkingRelation="1004" linkedAnnotations="1001"/><semantic:LinkedAnnotationSet xmi:id="1007" linkingRelation="1013" linkedAnnotations="1010"/><semantic:LinkedAnnotationSet xmi:id="1021" linkingRelation="1027" linkedAnnotations="1024"/><semantic:LinkedAnnotationSet xmi:id="1030" linkingRelation="1036" linkedAnnotations="1033"/><semantic:LinkedAnnotationSet xmi:id="1039" linkingRelation="1045" linkedAnnotations="1042"/><semantic:LinkedAnnotationSet xmi:id="1051" linkingRelation="1057" linkedAnnotations="1054"/><semantic:LinkedAnnotationSet xmi:id="1065" linkingRelation="1071" linkedAnnotations="1068"/><semantic:LinkedAnnotationSet xmi:id="1074" linkingRelation="1080" linkedAnnotations="1077"/><semantic:LinkedAnnotationSet xmi:id="1083" linkingRelation="1089" linkedAnnotations="1086"/><semantic:LinkedAnnotationSet xmi:id="1095" linkingRelation="1101" linkedAnnotations="1098"/><semantic:LinkedAnnotationSet xmi:id="1109" linkingRelation="1115" linkedAnnotations="1112"/><semantic:LinkedAnnotationSet xmi:id="1118" linkingRelation="1124" linkedAnnotations="1121"/><semantic:LinkedAnnotationSet xmi:id="1127" linkingRelation="1133" linkedAnnotations="1130"/><semantic:LinkedAnnotationSet xmi:id="1140" linkingRelation="1146" linkedAnnotations="1143"/><semantic:LinkedAnnotationSet xmi:id="1149" linkingRelation="1155" linkedAnnotations="1152"/><semantic:LinkedAnnotationSet xmi:id="1161" linkingRelation="1167" linkedAnnotations="1164"/><semantic:LinkedAnnotationSet xmi:id="1175" linkingRelation="1181" linkedAnnotations="1178"/><semantic:LinkedAnnotationSet xmi:id="1184" linkingRelation="1190" linkedAnnotations="1187"/><semantic:LinkedAnnotationSet xmi:id="1193" linkingRelation="1199" linkedAnnotations="1196"/><semantic:LinkedAnnotationSet xmi:id="1205" linkingRelation="1211" linkedAnnotations="1208"/><semantic:LinkedAnnotationSet xmi:id="1219" linkingRelation="1225" linkedAnnotations="1222"/><semantic:LinkedAnnotationSet xmi:id="1228" linkingRelation="1234" linkedAnnotations="1231"/><semantic:LinkedAnnotationSet xmi:id="1237" linkingRelation="1243" linkedAnnotations="1240"/><semantic:LinkedAnnotationSet xmi:id="1249" linkingRelation="1255" linkedAnnotations="1252"/><shared:ExternalReference xmi:id="34" namespace="GREC Concepts" ID="Repressor"/><shared:ExternalReference xmi:id="52" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="77" namespace="GREC Concepts" ID="Protein"/><shared:ExternalReference xmi:id="95" namespace="GREC Concepts" ID="Protein"/><shared:ExternalReference xmi:id="106" namespace="GREC Concepts" ID="Regulator"/><shared:ExternalReference xmi:id="117" namespace="GREC Concepts" ID="Protein"/><shared:ExternalReference xmi:id="135" namespace="GREC Concepts" ID="Mutant_Bacteria"/><shared:ExternalReference xmi:id="146" namespace="GREC Concepts" ID="Protein"/><shared:ExternalReference xmi:id="157" namespace="GREC Concepts" ID="Operon"/><shared:ExternalReference xmi:id="175" namespace="GREC Concepts" ID="Repressor"/><shared:ExternalReference xmi:id="186" namespace="GREC Concepts" ID="Regulator"/><shared:ExternalReference xmi:id="204" namespace="GREC Concepts" ID="Locus"/><shared:ExternalReference xmi:id="215" namespace="GREC Concepts" ID="Gene"/><shared:ExternalReference xmi:id="247" namespace="GREC Concepts" ID="Wild_Type_Bacteria"/><shared:ExternalReference xmi:id="258" namespace="GREC Concepts" ID="Operon"/><shared:ExternalReference xmi:id="276" namespace="GREC Concepts" ID="Protein"/><shared:ExternalReference xmi:id="294" namespace="GREC Concepts" ID="Mutant_Bacteria"/><shared:ExternalReference xmi:id="305" namespace="GREC Concepts" ID="RNA"/><shared:ExternalReference xmi:id="323" namespace="GREC Concepts" ID="Regulator"/><shared:ExternalReference xmi:id="334" namespace="GREC Concepts" ID="Protein"/><shared:ExternalReference xmi:id="352" namespace="GREC Concepts" ID="Regulator"/><shared:ExternalReference xmi:id="363" namespace="GREC Concepts" ID="RNA"/><shared:ExternalReference xmi:id="550" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="561" namespace="GREC" ID="Transcription"/><shared:ExternalReference xmi:id="572" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="583" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="594" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="605" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="616" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="627" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="638" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="649" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="660" namespace="GREC" ID="Regulation"/><shared:ExternalReference xmi:id="671" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="682" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="693" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="704" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="715" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="726" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="737" namespace="GREC" ID="Deletion"/><shared:ExternalReference xmi:id="748" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="759" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="770" namespace="GREC" ID="GRE"/><shared:ExternalReference xmi:id="781" namespace="GREC" ID="Gene_Expression"/><shared:ExternalReference xmi:id="795" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="804" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="813" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="825" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="839" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="848" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="857" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="870" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="879" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="891" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="904" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="913" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="925" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="938" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="947" namespace="GREC Concepts" ID="Location"/><shared:ExternalReference xmi:id="959" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="972" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="981" namespace="GREC Concepts" ID="Location"/><shared:ExternalReference xmi:id="995" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="1004" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="1013" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="1027" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="1036" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="1045" namespace="GREC Concepts" ID="Destination"/><shared:ExternalReference xmi:id="1057" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="1071" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="1080" namespace="GREC Concepts" ID="Location"/><shared:ExternalReference xmi:id="1089" namespace="GREC Concepts" ID="Rate"/><shared:ExternalReference xmi:id="1101" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="1115" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="1124" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="1133" namespace="GREC Concepts" ID="Temporal"/><shared:ExternalReference xmi:id="1146" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="1155" namespace="GREC Concepts" ID="Descriptive-Theme"/><shared:ExternalReference xmi:id="1167" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="1181" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="1190" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="1199" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="1211" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="1225" namespace="GREC Concepts" ID="Agent"/><shared:ExternalReference xmi:id="1234" namespace="GREC Concepts" ID="Theme"/><shared:ExternalReference xmi:id="1243" namespace="GREC Concepts" ID="Manner"/><shared:ExternalReference xmi:id="1255" namespace="GREC Concepts" ID="Theme"/><semantic:EventAnnotation xmi:id="542" sofa="1" begin="73" end="82" externalReference="550" linkedAnnotationSets="784"/><semantic:EventAnnotation xmi:id="553" sofa="1" begin="83" end="96" externalReference="561" linkedAnnotationSets="816"/><semantic:EventAnnotation xmi:id="564" sofa="1" begin="129" end="138" externalReference="572" linkedAnnotationSets="828"/><semantic:EventAnnotation xmi:id="575" sofa="1" begin="245" end="254" externalReference="583" linkedAnnotationSets="860"/><semantic:EventAnnotation xmi:id="586" sofa="1" begin="288" end="298" externalReference="594" linkedAnnotationSets="882"/><semantic:EventAnnotation xmi:id="597" sofa="1" begin="337" end="347" externalReference="605" linkedAnnotationSets="894"/><semantic:EventAnnotation xmi:id="608" sofa="1" begin="530" end="540" externalReference="616" linkedAnnotationSets="916"/><semantic:EventAnnotation xmi:id="619" sofa="1" begin="544" end="553" externalReference="627" linkedAnnotationSets="928"/><semantic:EventAnnotation xmi:id="630" sofa="1" begin="583" end="593" externalReference="638" linkedAnnotationSets="950"/><semantic:EventAnnotation xmi:id="641" sofa="1" begin="597" end="606" externalReference="649" linkedAnnotationSets="962"/><semantic:EventAnnotation xmi:id="652" sofa="1" begin="745" end="754" externalReference="660" linkedAnnotationSets="984"/><semantic:EventAnnotation xmi:id="663" sofa="1" begin="767" end="772" externalReference="671" linkedAnnotationSets="1016"/><semantic:EventAnnotation xmi:id="674" sofa="1" begin="905" end="915" externalReference="682" linkedAnnotationSets="1048"/><semantic:EventAnnotation xmi:id="685" sofa="1" begin="965" end="974" externalReference="693" linkedAnnotationSets="1060"/><semantic:EventAnnotation xmi:id="696" sofa="1" begin="1043" end="1053" externalReference="704" linkedAnnotationSets="1092"/><semantic:EventAnnotation xmi:id="707" sofa="1" begin="1112" end="1122" externalReference="715" linkedAnnotationSets="1104"/><semantic:EventAnnotation xmi:id="718" sofa="1" begin="1329" end="1339" externalReference="726" linkedAnnotationSets="1136"/><semantic:EventAnnotation xmi:id="729" sofa="1" begin="1342" end="1350" externalReference="737" linkedAnnotationSets="1158"/><semantic:EventAnnotation xmi:id="740" sofa="1" begin="1398" end="1404" externalReference="748" linkedAnnotationSets="1170"/><semantic:EventAnnotation xmi:id="751" sofa="1" begin="1420" end="1430" externalReference="759" linkedAnnotationSets="1202"/><semantic:EventAnnotation xmi:id="762" sofa="1" begin="1453" end="1459" externalReference="770" linkedAnnotationSets="1214"/><semantic:EventAnnotation xmi:id="773" sofa="1" begin="1474" end="1484" externalReference="781" linkedAnnotationSets="1246"/><comparable:IDArray xmi:id="1258" array="1261" idType="t"/><semantic2:NucleicAcids xmi:id="44" sofa="1" begin="100" end="113" externalReference="52"/><semantic2:NucleicAcids xmi:id="149" sofa="1" begin="671" end="703" externalReference="157"/><semantic2:NucleicAcids xmi:id="196" sofa="1" begin="789" end="810" externalReference="204"/><semantic2:NucleicAcids xmi:id="207" sofa="1" begin="919" end="938" externalReference="215"/><semantic2:NucleicAcids xmi:id="250" sofa="1" begin="1057" end="1084" externalReference="258"/><semantic2:NucleicAcids xmi:id="297" sofa="1" begin="1354" end="1358" externalReference="305"/><semantic2:NucleicAcids xmi:id="355" sofa="1" begin="1488" end="1492" externalReference="363"/><semantic2:Proteins xmi:id="26" sofa="1" begin="0" end="41" externalReference="34"/><semantic2:Proteins xmi:id="69" sofa="1" begin="216" end="229" externalReference="77"/><semantic2:Proteins xmi:id="87" sofa="1" begin="302" end="315" externalReference="95"/><semantic2:Proteins xmi:id="98" sofa="1" begin="394" end="397" externalReference="106"/><semantic2:Proteins xmi:id="109" sofa="1" begin="525" end="529" externalReference="117"/><semantic2:Proteins xmi:id="138" sofa="1" begin="578" end="582" externalReference="146"/><semantic2:Proteins xmi:id="167" sofa="1" begin="758" end="761" externalReference="175"/><semantic2:Proteins xmi:id="178" sofa="1" begin="763" end="766" externalReference="186"/><semantic2:Proteins xmi:id="268" sofa="1" begin="1126" end="1151" externalReference="276"/><semantic2:Proteins xmi:id="315" sofa="1" begin="1408" end="1411" externalReference="323"/><semantic2:Proteins xmi:id="326" sofa="1" begin="1415" end="1419" externalReference="334"/><semantic2:Proteins xmi:id="344" sofa="1" begin="1463" end="1466" externalReference="352"/><semantic2:LivingSystems xmi:id="127" sofa="1" begin="557" end="570" externalReference="135"/><semantic2:LivingSystems xmi:id="239" sofa="1" begin="987" end="1005" externalReference="247"/><semantic2:LivingSystems xmi:id="286" sofa="1" begin="1320" end="1328" externalReference="294"/><semantic2:EventArgumentSpan xmi:id="37" sofa="1" begin="62" end="72"/><semantic2:EventArgumentSpan xmi:id="55" sofa="1" begin="118" end="128"/><semantic2:EventArgumentSpan xmi:id="62" sofa="1" begin="139" end="150"/><semantic2:EventArgumentSpan xmi:id="80" sofa="1" begin="235" end="244"/><semantic2:EventArgumentSpan xmi:id="120" sofa="1" begin="554" end="570"/><semantic2:EventArgumentSpan xmi:id="160" sofa="1" begin="734" end="744"/><semantic2:EventArgumentSpan xmi:id="189" sofa="1" begin="773" end="785"/><semantic2:EventArgumentSpan xmi:id="218" sofa="1" begin="919" end="961"/><semantic2:EventArgumentSpan xmi:id="225" sofa="1" begin="975" end="983"/><semantic2:EventArgumentSpan xmi:id="232" sofa="1" begin="984" end="1005"/><semantic2:EventArgumentSpan xmi:id="261" sofa="1" begin="1104" end="1111"/><semantic2:EventArgumentSpan xmi:id="279" sofa="1" begin="1152" end="1191"/><semantic2:EventArgumentSpan xmi:id="308" sofa="1" begin="1389" end="1397"/><semantic2:EventArgumentSpan xmi:id="337" sofa="1" begin="1444" end="1452"/><cas:View sofa="1" members="784 792 801 810 816 822 828 836 845 854 860 867 876 882 888 894 901 910 916 922 928 935 944 950 956 962 969 978 984 992 1001 1010 1016 1024 1033 1042 1048 1054 1060 1068 1077 1086 1092 1098 1104 1112 1121 1130 1136 1143 1152 1158 1164 1170 1178 1187 1196 1202 1208 1214 1222 1231 1240 1246 1252 1261 8 21 13 789 798 807 819 833 842 851 864 873 885 898 907 919 932 941 953 966 975 989 998 1007 1021 1030 1039 1051 1065 1074 1083 1095 1109 1118 1127 1140 1149 1161 1175 1184 1193 1205 1219 1228 1237 1249 34 52 77 95 106 117 135 146 157 175 186 204 215 247 258 276 294 305 323 334 352 363 550 561 572 583 594 605 616 627 638 649 660 671 682 693 704 715 726 737 748 759 770 781 795 804 813 825 839 848 857 870 879 891 904 913 925 938 947 959 972 981 995 1004 1013 1027 1036 1045 1057 1071 1080 1089 1101 1115 1124 1133 1146 1155 1167 1181 1190 1199 1211 1225 1234 1243 1255 542 553 564 575 586 597 608 619 630 641 652 663 674 685 696 707 718 729 740 751 762 773 1258 44 149 196 207 250 297 355 26 69 87 98 109 138 167 178 268 315 326 344 127 239 286 37 55 62 80 120 160 189 218 225 232 261 279 308 337"/></xmi:XMI>