Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: mif 1
 1,449 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)

Both in the behavioral despair test and in the learned helplessness test, the antidepressant-like activity of oxytocin (0.500 mg/Kg i.p.) was prevented by the administration of a protease inhibitor (EACA, 400 mg/Kg i.p.; pepstatin, 0.1 mg/Kg i.p.). On the other hand, the linear tripeptide tail of oxytocin, MIF-1, was inactive in the behavioral despair test, and less active than oxytocin in the learned helplessness test. We conclude that the antidepressant activity of oxytocin is due to its cleavage to some smaller fragment(s) different from MIF-1.
 ...
PMID:Influence of protease inhibitors on the antidepressant activity of oxytocin. 289 Oct 75

Previous studies have shown effects of MIF-1 (prolyl-leucyl-glycinamide) and Tyr-MIF-1 (tyrosyl-prolyl-leucyl-glycinamide) in animal models of depression and also effects on dopaminergic function. These observations prompted us to examine whether the effects of the two peptides in the behavioral 'despair' test were modulated by dopamine antagonists. MIF-1 and Tyr-MIF-1, at the small dose of 0.01 mg/kg i.p. (24, 5 and 1 h before the test), produced a significant anti-immobility effect. This effect was antagonized by a single injection of either haloperidol or sulpiride, two dopamine receptor blockers. The same low dose of the tricyclic antidepressant desipramine was without significant effect in this test. The results indicate that Tyr-MIF-1, like MIF-1, is active in the behavioral despair test for antidepressants and that at least some of the CNS actions of these peptides are mediated by dopamine receptors.
 ...
PMID:Blockade of brain dopamine receptors antagonizes the anti-immobility effect of MIF-1 and Tyr-MIF-1 in rats. 290 71