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The meningeal tissue of the brain and spinal cord of larval and juvenile adults of lampreys (Petromyzon marinus) was examined by routine electron microscopy, electron microscopic histochemistry, and electron-probe x-ray microanalysis to locate sites of iron deposition. A magnetometer was used for identification of ferromagnetic iron. Ferritin particles, representing ferric iron, are present in abundance within the cytoplasmic matrices and in dense bodies of meningeal cells of both the brain and spinal cord of larvae and juveniles. These round cells of the meninges also contain abundant glycogen and lipid. Small quantities of ferrous iron are associated to the latter inclusion. Aluminum deposits are present within an electron-dense material of many ferritin-containing inclusions of meningeal cells of the larval brain. Ferromagnetic material was not detected in larval and upstream-migrant lampreys. The deposition of iron and aluminum in the meninges of lampreys may be related to physiological and environmental factors, respectively, and/or to an important interaction between the two metals.
Anat Rec 1989 Jan
PMID:Iron and aluminum deposition in the meninges of the lamprey: identification of an aluminum-ferritin inclusion body. 253 47

The luminal membrane of ileal absorptive cells in suckling rats includes two domains: microvillar membranes and deep invaginations between microvilli. We examined the fates of foreign macromolecules that bind to anionic or saccharide sites on these domains after infusion into ligated loops in vivo. Cationized ferritin (CF) and ferritin-RCAI (beta-galactosyl) binding sites were distributed over the entire apical membrane. Ligands bound to apical invaginations were rapidly endocytosed, but ligands on microvilli were not. After CF binding, anionic sites on microvilli were mobile in the plane of the membrane and formed CF clusters at the tip and base of each microvillus. RCAI binding sites did not cluster. Wheat germ agglutinin (WGA, sialic acid) labeling was restricted to microvillus tips of mature cells but was dispersed over the microvillar surfaces of lower villus cells. Ferritin conjugates of Concanavalia ensiformis (Con A), Ulex europaeus agglutinin (UEA), and Dolichos biflorus agglutinin (DBA) did not bind to cell surfaces in vivo. Aldehyde fixation dramatically altered lectin binding patterns, resulting in unmasking and labeling of Con A, WGA, and DBA binding sites that were unavailable in vivo.
Anat Rec 1985 Dec
PMID:Glycoconjugate distribution and mobility on apical membranes of absorptive cells of suckling rat ileum in vivo. 408 33

The integument of larval, parasitic adult, and upstream-migrant lampreys (Petromyzon marinus) was examined for iron deposition using light microscopic histochemistry and routine and histochemical procedures in the electron microscope. Ferritin particles, representing ferric iron, are present throughout most of the cytoplasmic matrix and within dense granules and vacuoles of epidermal mucous cells, but are not located in skein or granular cells. These particles are abundant in mucous cells of the dorsal surface but not the ventral surface and are more concentrated in adult lampreys compared to larva. Histochemistry revealed only sparse amounts of ferrous iron. Iron is not present in the dermis but is found in adipocytes of a subcutaneous layer. The deposition of integumentary iron is discussed with reference to body pigmentation and excretion of this metal.
Anat Rec 1984 Aug
PMID:Iron deposition in the integument of lampreys. 647 17

Previous studies demonstrated that the main excretory duct (MED) of the rat submandibular gland can internalize exogenous protein in addition to reabsorbing and secreting electrolytes. However, more precise studies have not been conducted. The aim of this study was to elucidate the cell types responsible for endocytosis of an exogenous protein (ferritin) and to follow the movements of the endocytosed protein in the ductal epithelial cells. The MEDs of the right submandibular gland of male Wistar rats were exposed near the glands proper and cationized ferritin solution was injected into each MED through a fine glass cannula. The MEDs were removed at intervals after ferritin injection, fixed and examined by transmission electron microscopy. The epithelium of the MED of the rat submandibular gland was pseudostratified and consisted of light (types I and II), dark, tuft and basal cells. Uptake of ferritin by the light (types I and II) and dark cells occurred frequently. Small vesicles and multivesicular bodies containing ferritin particles were observed in the supra-nuclear and lateral nuclear cytoplasm. Endocytosis of tracers by tuft cells was rare. Some of the small vesicles and the multivesicular bodies were acid phosphatase-positive. By 60 min after treatment, ferritin-containing small vesicles and multivesicular bodies appeared in the basal cytoplasm. Ferritin particles were also observed in basal extracellular spaces. The light (types I and II), dark and tuft cells (latter rarely) participated in endocytosis of exogenous proteins in the epithelium of the MED of the rat submandibular gland. Almost all of the internalized proteins appeared to be processed by the lysosomal system, and some proteins were released into the extracellular spaces.
Anat Rec 2000 Jan 01
PMID:Uptake of cationized ferritin by the epithelium of the main excretory duct of the rat submandibular gland. 1060 54