Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Efforts have been made to endorse the thory of a viral aetiology for the feline urolithiasis syndrome (FUS) in the male cat. The presence of virus in the urine of three cases could not be confirned nor could the condition be transmitted by intra vesicular inoculation of urine from four affected cats into the bladders of normal cats. Following these negative findings work was done on SPF cats and a survey made of the incidence of urethral obstruction in six SPF cat units in England. No cases were reported from four of these units over a two-year period. Five cases occurred in the other two SPF units, three of which were associated with feeding an expanded dry cat food. There is, thus, no direct evidence that viral agents are involved in the aetiology of FUS.
Vet Rec 1975 Jul 26
PMID:The case against a viral aetiology in feline urolithiasis. 23 80

Pancreatitis-associated protein (PAP) is a secretory protein that is not only expressed during acute pancreatitis but also in pancreatic adenocarcinoma, gastric carcinoma, hepatocellular carcinoma, and colorectal carcinoma. Expression in carcinoma might be another characteristic of PAP. The aim of our study was to assess, in 27 patients undergoing surgery for colorectal carcinoma, the expression of the PAP mRNA and to evaluate its association with DNA ploidy and proliferative activity (S-phase fraction, SPF) by reverse transcriptase-polymerase chain reaction (RT-PCR) and flow cytometric analysis (FCM). PAP mRNA was expressed in 29.6% (8 of 27) of the patients with colorectal carcinoma. DNA aneuploid and high SPF were found in 87.5% (7 of 8) of patients with PAP mRNA positive colorectal carcinoma. The serum PAP level was significantly elevated in patients with colorectal carcinoma when compared with the healthy subjects. Twelve of the 27 patients with colorectal carcinoma had high serum PAP concentrations (>25 ng/mL) and the mean SPF was 17.82% +/- 8.02%, which was significantly higher compared with the normal colorectal tissue group (7.33% +/- 3.18%, P < 0.05). The mean serum PAP concentration of DNA aneuploidy colorectal carcinomas was 46.67 +/- 17.58 ng/mL, which was significantly different when compared with the DNA diploidy group (19.18 +/- 8.89 ng/mL, P < 0.05). PAP mRNA expression and serum PAP levels are closely related to neoplastic proliferative activity in patients with colorectal carcinoma. No significant differences are observed between PAP mRNA expression and clinicopathologic parameters (P > 0.05).
Anat Rec (Hoboken) 2009 Feb
PMID:Pancreatitis-associated protein is related closely to neoplastic proliferative activity in patients with colorectal carcinoma. 1905 Dec 57