Gene/Protein Disease Symptom Drug Enzyme Compound
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 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We continued our research into the biological properties of quinoline derivatives. Newly synthesized 8-sulfonylquinolines, tested against some representative microbial strains and practically inactive, were also studied for the genotoxic properties. The genotoxicity tests were extended to previously synthesized compounds (some 6-substituted 8-quinolinecarboxylic acids, the amide and some esters of 8-quinolinecarboxylic acid and finally the 8-quinolinecarboxaldehyde and two of its derivatives). Rec-assay and Salmonella-microsome tests showed several compounds to be genotoxic; the mutagenic activity seems to be modulated by the nature of the substituents. The results obtained are discussed with the aim of explaining possible structure-activity relationships.
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PMID:Antimicrobial and genotoxic properties of quinoline derivatives. 806 39