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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Milk fever is a disease of increasing importance. In dairy herds its incidence has doubled since 1950; today about 8 per cent of parturitions in Swedish dairy cattle are complicated by milk fever. At the same time, the clinical picture has changed and the effectiveness of calcium therapy has been markedly reduced. Thirty to 40 per cent of cows with milk fever need more than one treatment. These trends are obvious in Sweden and Norway and have been reported from many other parts of the world. However, there are also geographical and breed differences so that these figures might not be applicable under British conditions.
Vet Rec 1978 Feb 25
PMID:Milk fever prevention. 2 7

Normal, rachitic, and vitamin D3-replete chicken growth plates were studied utilizing the potassium pyroantimonate-osmium tetroxide procedure. A marked membrane and mitochondrial calcium was revealed in all specimens in the maturing and early hypertrophic zones which disappeared as heavy matrix mineralization began. The most significant difference shown in the specimens was in the marked intracellular lipid content of chondrocytes in all zones of the rachitic and D3-replete growth plates. There was negligible lipid present in normal specimens. It is suggested that as most of the mechanisms postulated as necessary for calcification are present in rachitic chicks, perhaps the increased intracellular lipid pool results from the formation of abnormal lipids for insertion into the plasma membrane and thus prevents normal calcium transport. Chains of intracellular vesicles were also visualized in maturing and hypertrophic chondrocytes. These were more often seen in rachitic growth plates and in increased numbers in the early D3-replete specimens. The etiology is unknown at the present time.
Anat Rec 1978 Jan
PMID:Calcium localization in normal rachitic, and D3-treated chicken epiphyseal chondrocytes utilizing potassium pyroantimonate-osmium tetroxide. 20 24

One hundred and thirty four cases of hypocalcaemia (parturient paresis) between April and Jul 1976 from 72 herds in the UK and Eire were used to compare the response to intravenous treatments with one of three solutions containing calcium salts. Two solutions contained 8 g calcium, one with added magnesium (1.03 g), a third solution contained 6.2 g calcium. The biochemical response obtained 24 hours after successful treatment from all solutions was similar. The clinical response with both 8 g calcium solutions was similar and significantly superior to that obtained with 6.2 g calcium (P less than 0.02 greater than 0.01). More cases (44 per cent) relapsed after treatment with 6.2 g calcium. There was no evidence that the added magnesium to the calcium solution improved the clinical response of parturient paresis cases in this spring claving season, as had been suggested previously. The herds providing these 134 cases had recorded an incidence of 8.04 per cent for parturient paresis in 1975.
Vet Rec 1977 Nov 12
PMID:Milk fever: a case against polypharmacy solutions. 24 19

Dense crystalline deposits appeared within vacuoles in rat maturative ameloblasts as a result of repeated injections of sodium fluoride. The crystals assumed varied arrangements but were always observed within intracellular vacuoles. The crystals resemble those of normal enamel and resist microincineration. They are readily dissolved by decalcification and leave behind an organic framework which matches the outline of the crystals. An experimental model is presented which may be useful in further studies of calcium transport, enamel matrix absorption or digestion of cellular debris.
Anat Rec 1978 May
PMID:Fluoride-induced mineralization within vacuoles in maturative ameloblasts of the rat. 34 79

Carotid bodies from adult rats were electron microscopically studied after incubation in glucose-containing salt solutions containing calcium and/or ionophore A23187 or neither. In the absence of the ionophore, adding or omitting calcium had no effect on the fine structure of the glomus cells. Incubation in the medium containing both 1 mM calcium and the ionophore caused the appearance of exocytotic membrane profiles in several glomus cells. Exocytosis was not seen when only A23187 and endogenous calcium was present. For exocytosis to occur, calcium appeared to be essential and the event seemed to be due to a rise in the intracellular calcium concentration caused by the ionophore.
Anat Rec 1979 Oct
PMID:Induction of exocytosis from glomus cells by incubation of the carotid body of the rat with calcium and ionophore A23187. 38 92

The distribution of calcium in the enamel organ of the rat incisor was investigated using potassium pyroantimonate for ultrastructural localization of calcium. Substantial amounts of precipitate occurred in the intercellular compartment of the enamel organ and modest deposits were observed in specific organelles of the secretory ameloblast. Mitochondria, nuclei granular endoplasmic reticulum, Golgi vesicles and secretory granules consistently contained small deposits of pyroantimonate. Complexing of calcium by the pyroantimonate was confirmed by EGTA decalcification and scanning electron microscope energy dispersive X-ray analysis. The observed distribution is discussed in light of potential for an intercellular pathway of calcium transport as well as controlled movement of the ion along the synthetic and secretory route followed by organic components of enamel.
Anat Rec 1979 Mar
PMID:Calcium transport and the secretory ameloblast. 42 3

Five out of 60 purebred Suffolk lambs died when four to six weeks old with a nephrosis characterised by heavy deposits of crystals resembling calcium oxalate in the tubules. The source of oxalate was not clearly identified but may have resulted from oxalate-forming mould contamination of concentrates fed to both ewes and lambs.
Vet Rec 1979 May 12
PMID:Spontaneous renal disease resembling hyperoxaluria in young lambs. 47 47

An 18-week-old male German shepherd dog had a convulsion following the accidental ingestion of bromocyclen two hours previously. The dog then vomited and had a second convulsion. A pulse rate of 150 per minute and a respiratory rate of 54 per minute were recorded. The dog was treated with 2mg acepromazine and 0.6mg atropine administered intramuscularly (im) and repeated every four hours, 10ml of 20 per cent calcium borogluconate administered subcutaneously and 2ml penicillin and streptomycin im. Eighteen hours later, the respiratory rate was in excess of 60 per minute, and penicillin and streptomycin plus 2mg betamethasone were administered im. Only atropine was administered over the next 12 hours and then discontinued. Forty hours after the original convulsion, the respiratory rate had fallen to 30 per minute and the pulse rate to 84 per minute. A day later, the dog had fully recovered.
Vet Rec 1979 May 19
PMID:Bromocyclen poisoning in the dog. 47 58

The oral administration of phenylbutazone at a dose rate of approximately 10 mg per kg per day for seven to 14 days resulted in the development of signs of toxicity in seven of eight ponies treated. Clinical signs included anorexia, depression and abdominal oedema. Blood biochemical determinations showed a decrease in total plasma protein and calcium concentrations with an increase in urea concentration. These changes were considered indicative of water retention. Three of the ponies died during treatment following the development of shock. Shock was considered to arise from the submucosal oedema of the large intestine observed on necropsy. Oral ulceration was also found in these animals. In two ponies intravenous administration of phenylbutazone (4.0 mg per kg) for seven days was studied. In one of these ponies a marked decrease in total plasma protein concentration occurred.
Vet Rec 1979 Jul 14
PMID:Phenylbutazone toxicity in ponies. 55 15

One member of each pair of twin lambs from 37 five-and six-year-old Scottish blackface ewes, grazing reseeded pasture suspected of causing a molybdenum-sulphur induced copper deficiency in sheep, was given an injection of 12.5 mg copper calcium edetate at about eight weeks of age. Plasma copper concentrations of these lambs were maintained in the normal range by further injections of copper as required (treatment group). The remaining member of each twin pair received no copper therapy (control group). The control lambs and all ewes showed marked hypocupraemia throughout lactation, whereas the plasma copper concentrations of the treatment lambs, and also of single lambs with continuous access to unimproved hill grazings, remained normal. The live-weight gain of the treatment lambs was significantly greater than that of the control lambs, the difference in mean live-weights after 12 weeks being 2.5 kg. All lambs showed some degree of osteoporosis; this was most severe in the control lambs which had less dense bones and were also more susceptible to bone fractures and to disease. Differences between treatment and control lambs were also observed in haematological parameters and in fleece characteristics.
Vet Rec 1979 May 19
PMID:A study of the effects of copper deficiency in Scottish blackface lambs on improved hill pasture. 57 17


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