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 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The reliability of a cytological examination of impression smears of the liver was investigated in 89 Bedlington terriers by using the rubeanic acid staining method for copper and comparing the results with the results of a histological examination. Histological examination revealed copper accumulation in the liver of 24 dogs. The cytological method had a sensitivity of 0.96 for detecting copper toxicosis and a specificity of 1.0. When a grading system for the amount of copper was applied, the coefficient of correlation (r) between the cytological and histological techniques was 0.917 (P less than 0.0001). It was concluded that a cytological examination of impression smears stained with rubeanic acid for copper offers a rapid and reliable method for the detection of copper toxicosis in Bedlington terriers.
Vet Rec 1992 Jul 11
PMID:Cytological detection of copper for the diagnosis of inherited copper toxicosis in Bedlington terriers. 141 18

An 18-month-old alpaca developed nervous signs, including swaying of the head and neck, a wide-based stance and hind-limb ataxia. No certain diagnosis was made but the animal recovered after successive treatment with amoxycillin, vitamin B1, ivermectin and copper oxide, followed by vitamin E and selenium. The differential diagnosis rationale of treatment is described.
Vet Rec 1992 Sep 05
PMID:Ataxia and head tremor in an alpaca (Lama pacos) 832 51

The ultrastructural localization of acetylcholinesterase (AChE) activity in guinea pig pineal gland was studied using the copper-glycine procedure. A small number of pinealocytes and bundles of unmyelinated nerve fibers were labeled by the AChE reaction. The AChE-positive pinealocytes were located near blood vessels and distributed in small groups. The AChE reaction product was localized in the perinuclear cistern, in the cisternae of the endoplasmic reticulum (ER), and in the saccules of the Golgi apparatus. These findings suggest that the AChE-positive pinealocytes synthesize AChE. The AChE reaction product was also seen in the intercellular space between pinealocyte processes. Besides pinealocytes, AChE activity was localized on the axolemma of myelinated and unmyelinated nerve fibers and in the basement membrane surrounding unmyelinated nerve fibers. Pseudocholinesterase activity was confined to Schwann cells, which showed the reaction product in their perinuclear cistern, in the cisternae of the ER, and on the plasmalemma.
Anat Rec 1990 Apr
PMID:Ultrastructural localization of acetylcholinesterase in the guinea pig pineal gland. 233 Oct 60

An acute phase reaction was elicited in four horses to which Freund's adjuvant was administered intramuscularly. The localised inflammation was accompanied by changes in the plasma concentrations of copper, iron and zinc. The plasma copper concentration, the plasma ceruloplasmin copper concentration and the ceruloplasmin oxidase activity in the plasma steadily increased to a maximum 24 days after the administration of the adjuvant. At this time, the plasma copper concentration was 2.2 micrograms/ml, a 90 per cent increase over the baseline concentration. The ratio of the concentration of plasma ceruloplasmin copper to plasma copper remained constant, indicating that the non-ceruloplasmin bound copper component of the plasma is also an acute phase reactant in the horse. The plasma zinc and iron concentrations decreased to 59 per cent and 30 per cent of their respective baseline concentrations and the severity of the inflammation appeared to influence the plasma concentrations of each metal. Weak correlations between the plasma fibrinogen concentration and the plasma copper and zinc concentrations of 25 horses with plasma fibrinogen concentrations of 5 g/litre or greater indicated that a single measurement of plasma copper concentration is not useful in the diagnosis of non-specific inflammatory disorders of the horse. However, the results suggest that the plasma copper concentrations in serial samples may be used to monitor the resolution of inflammatory disorders in the horse.
Vet Rec 1989 Mar 11
PMID:Acute phase response in horses: changes in plasma cation concentrations after localised tissue injury. 249 17

As a result of the delivery of 20 tons of concentrated aluminum sulphate solution into the wrong part of the Lowermoor water treatment works the water supplies of 20,000 people and many thousands of cows, sheep, pigs and poultry became contaminated with aluminium, copper, zinc and lead. When the water mains were flushed into the rivers Allen and Camel many fish were killed by the high concentrations of aluminium. However, there appear to have been no detrimental effects on farm live-stock; this was either because the animals were likely to have ingested less of the toxic elements from the water than they ingest with normal components of their diet, including soil, or because the abnormally high intakes lasted for only a short time.
Vet Rec 1989 May 06
PMID:Accidental contamination of the public water supply at Lowermoor, Camelford: an assessment of the possible veterinary consequences. 275 28

Pre-exposure of growing bacterial populations to low concentrations of hydrogen peroxide (H2O2) protects a repair-proficient strain of Escherichia coli (AB1157) very strongly and a rec A strain (AB2463) to a lesser extent from the lethal action of subsequent exposure to 5 mM H2O2 in buffer. The conditioning procedure also protects AB1157 and AB2463 from the toxic effects of UVA (334 nm, 365 nm) radiation but not UVB (313 nm) or UVC (254 nm) radiations. Pretreatment of growing AB1157 with low fluences of UVA (365 nm) radiation leads to the induction of resistance to H2O2, an effect which apparently requires protein synthesis. As in a previous report, the treatment of growing populations with low concentrations of H2O2 enhanced the resistance of such populations to H2O2 challenge in the growth medium. However, when H2O2 (+ Cu2+)-treated bacteriophage were subsequently infected into AB1157 under optimal inducing conditions, their resistance was not enhanced relative to infection into untreated bacteria. We conclude that the primary mechanism for the inducible effects observed could be the induction of H2O2 scavenging activity by low concentrations of H2O2 either introduced into the growth medium directly or produced by low fluences of UVA irradiation.
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PMID:A common pathway for protection of bacteria against damage by solar UVA (334 nm, 365 nm) and an oxidising agent (H2O2). 315 56

Effective control of copper poisoning in sheep was obtained by the subcutaneous injection of ammonium tetrathiomolybdate. Three doses, each of 3.4 mg/kg bodyweight, were given on alternate days. This treatment caused a substantial reduction in liver copper content and in liver damage. It also decreased the mortality rate in animals that had developed the haemolytic crisis. The subcutaneous route is as effective as the intravenous route and is more convenient. No adverse side-effects of the treatment were observed.
Vet Rec 1988 Jul 09
PMID:A convenient method for the treatment of chronic copper poisoning in sheep using subcutaneous ammonium tetrathiomolybdate. 341 42

Trials were carried out to compare the efficacy of copper heptonate with other available therapeutic products. On nine farms with a copper deficiency problem, over 2000 ewes were treated in mid-pregnancy. All the treatments increased whole blood copper levels and plasma caeruloplasmin (ferroxidase) activity in ewes, and protected their lambs from swayback. The lambs from ewes treated with copper heptonate and copper oxide needles had significantly higher blood copper levels than lambs from untreated control ewes. Treatment with copper heptonate was shown to have a therapeutic index of at least 5 in Swaledale ewes of normal copper status. In two groups of Welsh mountain sheep from different backgrounds, both with normal blood copper levels before treatment, the therapeutic indices were 3 to 5.
Vet Rec 1988 May 14
PMID:Copper heptonate for the treatment of hypocupraemia in sheep. 342 Jul 69

Two trials of oral copper oxide needles for cattle are described. In one, a dose of 13.0 g copper oxide/100 kg liveweight in yearling bullocks was compared with parenteral copper at a total dose rate of 400 mg copper. In the second, three oral dose rates (3.5, 7.0 and 10.5 g copper oxide/100 kg liveweight) in calves were compared over two years with a total dose of 500 mg parenteral copper. In both trials liver copper values reached a peak at about six weeks after oral dosing and in the second trial the peak was dose related. Thereafter liver levels declined in all the oral treatment groups; normal levels of more than 30 mg/kg liver dry matter were maintained for 30 weeks in the first trial and for 40 to 47 weeks, depending on dose rate, in the second. In both trials repeated parenteral treatments were required to maintain liver levels within the normal range. The results support earlier findings that an adequate dose of copper oxide needles can maintain the copper status of cattle for periods of at least six months.
Vet Rec 1988 Aug 06
PMID:Copper oxide needles for cattle: a comparison with parenteral treatment. 342 Jul 82

Clinical, biochemical and pathological findings led to a diagnosis of swayback in a herd of goats. Trace element values in soil, pasture and supplementary feed were measured, and copper oxide needles administered to the adult goats. This form of treatment had a more limited effect in these goats than is reported in sheep.
Vet Rec 1986 Jun 14
PMID:A farm investigation into swayback in a herd of goats and the result of administration of copper needles. 352 99


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