Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The hock of a greyhound containing a titanium alloy central tarsal replacement was examined histologically. The animal had raced competitively 43 times before retirement. The examination showed that the adaptation and encapsulation of the implant by the surrounding bones, together with the excellent purchase of the screw into the fourth tarsal bone, had maintained the implant in excellent position during vigorous load-bearing. There was no histopathological evidence to suggest that the fixation of the implant was failing. The results provide evidence for the value of titanium alloy implants as a central tarsal replacement in greyhounds with type V fractures, and as a feasible alternative to euthanasia.
Vet Rec 1989 Apr 01
PMID:Histological analysis of a central tarsal implant in a racing greyhound. 271 24

During growth the muscles of mastication alter their lines of action. Research on long bones indicates that the apparent migration of muscle attachments is due to the movement of the periosteum relative to the underlying bone. To assess whether the pig masseter muscle follows the periosteum during growth, implants of titanium granules in a gelatin matrix were placed simultaneously in various parts of the masseter muscle and its periosteal and bony attachments. Growth movements of these tissues were followed radiographically for 2 months. Granule position was verified histologically. Periosteal movement was the dominant growth process at the insertion of the masseter. All implants migrated caudally relative to the mandible. However, a strong position effect was seen dorsoventrally: implants placed high in the ascending ramus migrated dorsally as well as caudally; low implants migrated only caudally. This differential migration, ascribed to the influence of the condyle, accounts for the increasing horizontal orientation of dorsal fibers. A similar differential was seen along the rostrocaudal axis of the ramus. In contrast to the insertion, the origin of the masseter from the zygomatic arch shows no periosteal movement. Rather, the entire bone-muscle complex becomes displaced by sutural growth, leading to increasing vertical orientation of the masseter. Thus two different aspects of skull growth are responsible for the change in muscle anatomy.
Anat Rec 1993 Feb
PMID:Bone growth and periosteal migration control masseter muscle orientation in pigs (Sus scrofa). 842 Mar 91

A two-and-a-half-year-old Jersey cow had been moderately lame in its right hindlimb for one month. Clinical and radiographic examinations revealed an incomplete lateral luxation of the metatarsophalangeal joint. The medial condyle of the metatarsal bone was locked in the condylar groove of the medial first phalanx. The subluxation was reduced, the joint carefully debrided and irrigated, and the torn ligament was replaced with a synthetic prosthesis which was fixed with titanium alloy staples. One year after surgery, the joint was slightly swollen but the cow was not lame.
Vet Rec 2000 May 27
PMID:Collateral ligament prosthesis for the repair of subluxation of the metatarsophalangeal joint in a jersey cow. 1087 85

An overview of the optical limiting (OL) processes in phthalocyanines and related compounds is presented, particularly a description of the synthesis and relevant optical properties of a series of axially substituted indium(III), titanium(IV), phthalo- and naphthalocyanines, and octaarylporphyrazines. Several techniques, such as transient absorption, Z-scan, and degenerate four-wave mixing, were used to assess the optical properties and OL performance of the investigated compounds. The versatility of the methods of organic synthesis leads to the achievement of effective systems in terms of OL performance through the appropriate combination and modulation of several structural components. The chemistry of the macrocycles here considered allows the variation of the different chemical features, such as the degree of electronic conjugation of the macrocycle and the nature of the ring substituents, the central atom, and the ligands attached to the central atom.
Chem Rec 2002
PMID:Conjugated macrocycles as active materials in nonlinear optical processes: optical limiting effect with phthalocyanines and related compounds. 1211 66

Various titanium carbene complexes are prepared by the reductive titanation of thioacetals, gem-dihalides, and related organosulfur and organohalogen compounds with the titanocene(II) reagent Cp(2)Ti[P(OEt)(3)](2). Alkylidene-, heteroatom-substituted methylidene-, 2-alkenylidene-, 2-alkynylidene-, and vinylidene-titanocenes thus formed are highly reactive toward organic compounds bearing a multiple bond and are employed for a variety of organic transformations such as carbonyl olefination and olefin metathesis.
Chem Rec 2007
PMID:Titanium carbene complexes as useful tools in organic synthesis. 1730 90

Osseointegration is regarded as the most appropriate implant-bone interface in dental implantation. However, damaged bone with empty osteocytic lacunae driven by implant cavity preparation remains even after the completion of osseointegration. Although previous studies have suggested the occurrence of bone remodeling around implants, information on its detailed process is meager. Our study aimed to examine the fate of bone around titanium implants after the establishment of osseointegration on an animal model using the rat maxilla. Titanium implants were inserted into prepared bone cavities of the rat maxilla. Bone formation and maturation processes were evaluated by double staining for alkaline phosphatase and tartrate-resistant acid phosphatase, immunohistochemistry for bone matrix proteins, vital staining with calcein, and elemental mapping with an electron probe microanalyzer. Bone with empty osteocytic lacunae or pyknosis remained between the intact preexisting and newly formed woven bones at post 1 month. It gradually decreased to disappear completely by active bone remodeling with a synchronized coordination of alkaline phosphatase-positive osteoblasts and tartrate-resistant acid phosphatase-reactive osteoclasts at post 3 months, thickening to be replaced by compact bone. Dynamic labeling showed two clear lines in the newly formed bone around the implant through this experimental period. Electron probe microanalyzer analysis demonstrated chronologically increased levels of Ca and P in the newly formed bone identical to those in the surrounding bone at post 2.5 months. These findings indicate that continuous bone remodeling after the achievement of osseointegration causes replacement of the damaged bone by compact bone as well as an improvement in bone quality. Anat Rec, 2009. (c) 2008 Wiley-Liss, Inc.
Anat Rec (Hoboken) 2009 Jan
PMID:Detailed process of bone remodeling after achievement of osseointegration in a rat implantation model. 1872 13

Interaction of titanium(IV) isopropoxide with ethylmagnesium bromide and its higher homologs leads to the generation of alkoxytitanacyclopropane species, which are able to act in the reactions with unsaturated compounds as 1,2-dicarbanionic alkylating agents. The present review is focused on the processes of intermolecular regio- and stereoselective alkylation of carboxylic esters and allylic alcohol derivatives with alkoxytitanacyclopropane reagents. The oxophilicity of the titanium atom and its tendency to form sterically crowded ate complexes are probably the main factors providing a high level of selectivity of these transformations.
Chem Rec 2008
PMID:Stereocontrolled alkylation of unsaturated compounds with alkoxytitanacyclopropane reagents. 1895 60

Tissues of mice that had had microchip transponders with surfaces made of bioglass, bioglass with a polypropylene cap, parylene C, titanium or aluminium oxide inserted were examined histologically, and the growth of two lines of feline fibroblastoid cells around these transponders was examined in vitro. The results for bioglass and aluminium oxide were similar. In vitro, there were almost no cells around or on the transponders; in vivo, there was often granulomatous inflammation in the surrounding tissue. In the case of the bioglass, this reaction seemed to be induced by petrolatum, which was added by the manufacturer for technical reasons, rather than by the bioglass itself. In some of the mice, polypropylene caused a proliferation of granulation tissue. In vitro, the cellularity around the transponders was high, but only a moderate number of cells were found on the material. In vivo, around the parylene C transponders, there were occasionally small fragments of foreign material, surrounded by a foreign body reaction; in vitro, the results for parylene C resembled those for polypropylene. In vivo, particles of titanium were sometimes visible in the connective tissue adjacent to the titanium transponders, and sometimes accompanied by a foreign body reaction; in vitro, a confluent layer of cells developed on the transponders, with a high cellularity around them.
Vet Rec 2009 Jul 11
PMID:In vivo reactions in mice and in vitro reactions in feline cells to implantable microchip transponders with different surface materials. 1959 75

Osseointegration is the most preferable interface of dental implants and newly formed bone. However, the cavity preparation for dental implants often gives rise to empty lacunae or pyknotic osteocytes in bone surrounding the dental implant. This study aimed to examine the chronological alternation of osteocytes in the bone surrounding the titanium implants using a rat model. The distribution of the osteocytic lacunar canalicular system (OLCS) in bone around the titanium implants was examined by silver impregnation according to Bodian's staining. We also performed double staining for alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP), as well as immunohistochemistry for fibroblast growth factor (FGF) 23--a regulator for the serum concentration of phosphorus--and sclerostin, which has been shown to inhibit osteoblastic activities. Newly formed bone and the injured bone at the early stage exhibited an irregularly distributed OLCS and a few osteocytes positive for sclerostin or FGF23, therefore indicating immature bone. Osteocytes in the surrounding bone from Day 20 to Month 2 came to reveal an intense immunoreactivity for sclerostin. Later on, the physiological bone remodeling gradually replaced such immature bone into a compact profile bearing a regularly arranged OLCS. As the bone was remodeled, FGF23 immunoreactivity became more intense, but sclerostin became less so in the well-arranged OLCS. In summary, it seems likely that OLCS in the bone surrounding the dental implants is damaged by cavity formation, but later gradually recovers as bone remodeling takes place, ultimately inducing mature bone.
Anat Rec (Hoboken) 2011 Jun
PMID:A morphological analysis on the osteocytic lacunar canalicular system in bone surrounding dental implants. 2153 31

Selected problems of electrochemical synthesis, characterization and applications of titanium dioxide are reviewed. These issues have attracted considerable attention from addressing purely academic questions up to promising applications in devices for energy storage and energy conversion.
Chem Rec 2012 Feb
PMID:Electrochemistry of titanium dioxide: some aspects and highlights. 2213 Nov 94


1 2 Next >>