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Serum pepsinogen estimations from serially bled lambs grazing on pasture from spring to autumn showed correlations with the availability of Ostertagia larvae on pasture, with faecal egg counts of O circumcincta, and with Ostertagia worm counts in similar lambs slaughtered fort-nightly from the same pasture. In the slaughtered lambs correlations were recorded between worm count, serum pepsinogen level and abomasal pH. The value of serum pepsinogen estimations as a diagnostic test is discussed with reference to these findings.
Vet Rec 1975 Dec 13
PMID:Significance of serum pepsinogen and abomasal pH levels in a field infection of O circumcincta in lambs. 0 Aug 42

Gastric mucosa of an elasmobranch species was examined by electron microscope. The gastric glands contain one form of cell whose fine structure is similar to the cell that secretes both hydrochloric acid and pepsinogen of the amphibian gastric glands proper. The oxynticopeptic cells are characterized by: (a) a luminal surface with long projections of cytoplasm having dilatations in their thickness; (b) a tubulo-vesicular system in the apical cytoplasm; (c) a great number of mitochondria, some of which are of great length; (d) a well developed granular endoplasmic reticulum and a conspicuous Golgi apparatus; and (e) a large nucleus with a conspicuous nucleolus. A fourth part of the cells are binucleated. Physiological implications of some of these ultrastructural features are discussed.
Anat Rec 1979 Apr
PMID:Fine structure of the oxynticopeptic cell in the gastric glands of an elasmobranch species (Halaelurus chilensis). 42 7

The epidemiology of ostertagiasis in south west Scotland was studied in groups of cattle grazed through two successive grazing seasons separated by a period of winter housing. Towards the end of the first grazing season (September) the numbers of infective larvae (L3) on the pasture had increased to high levels (up to 24,000 L3 per kg) which resulted in high faecal egg counts, worm burdens, plasma pepsinogen levels and the occurrence of clinical ostertagiasis in the calves. By late spring (May) at the onset of the second grazing season, there was an almost complete mortality of the overwintered L3 on the pasture followed by the appearance of moderately high numbers of a new population of L3 in September (up to 9000 L3 per kg). The latter increase in the numbers of L3 was reflected by negligible faecal egg counts, low worm burdens and a moderate elevation of plasma pepsinogens in the second year animals. It therefore seems that although young cattle acquire a good immunity to Ostertagia ostertagi after one season at grass the small infections established in the early part of the second season are capable of contaminating the pasture to levels which could be dangerous for susceptible stock. An allergic reaction in the abomasal mucosa could be the basis of the elevated pepsinogens present in the second year animals.
Vet Rec 1979 Dec 01
PMID:Observations on ostertagiasis in young cattle over two grazing seasons with special reference to plasma pepsinogen levels. 52 7

Studies carried out on nine farms in north-west England indicated that fenbendazole treatment of adult winter calving dairy cows in the dry period caused an overall increase of 173 kg in their subsequent lactation yield. There was some evidence to suggest that a correlation existed between pasture Ostertagia ostertagi larval burdens and subsequent serum pepsinogen and milk yield responses post treatment. Marked interherd and regional differences existed in the milk yield response to anthelmintic treatment and possible reasons for such results are discussed.
Vet Rec 1979 Dec 01
PMID:The effect of a preparturient fenbendazole treatment on lactation yield in dairy cows. 52 9

Two groups of calves were infected with larvae of Ostertagia ostertagi to establish large numbers of adults and arrested larvae. In one group symptoms of ostertagiasis were seen and there was a loss of three months growth; in the other, in which adult worms were removed by a single anthelmintic treatment, there was only a transient reduction in live-weight gain. Plasma pepsinogen levels were however the same in the two groups and followed the same course. Even after 25 weeks, when calves had been growing normally for up to three months, plasma pepsinogen values were still around 5 iu per litre, well above the level generally regarded as diagnostic of ostertagiasis. The relevance of these findings to the use of the test in the diagnosis of ostertagiasis is discussed. The literature is reviewed.
Vet Rec 1978 Oct 21
PMID:Plasma pepsinogen levels in some experimental infections of Ostertagia ostertagi in cattle. 57 Mar 16

Research on the activity of self-cleaving proteases in bacterial, mammalian and virus-infected cells is reviewed, with an emphasis on the diversity of regulatory systems controlled by protein processing. Each of these three groups will be considered in turn by focusing on the following systems: the Rec A-dependent intramolecular cleavage of the Escherichia coli SOS response protein, LexA; the intramolecular activation of the mammalian aspartic acid protease, pepsinogen; and the autocatalytic cleavage of polyproteins synthesized by picornaviruses.
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PMID:Self-cleaving proteases. 181 62

The localization of progastricsin was studied in cells of abomasal mucosa from cattle of different ages and feeding regimes and compared to the localization of prochymosin and pepsinogen in the same material by use of an immunofluorescence technique with specific rabbit antibodies. Immunoreactivity for progastricsin was first found in calves at the age of about 45 days in surface mucous cells in the pit of the fundic gland. In older calves and adults, mucous neck cells also produced progastricsin. In the pyloric mucosa, on the other hand, traces of progastricsin immunoreactivity were found in the lower base of the pyloric gland even in newborn calves. When the calves grew older, progastricsin-immunoreactive cells also developed in the pit and later in the neck of the pyloric gland; and the number of these cells in this region increased with age. The development of progastricsin-producing cells seemed to be influenced only by age and not by the feeding of milk to the calves. The ontogeny of progastricsin, prochymosin, and pepsinogen exhibited an interesting pattern in cattle, as they started to be produced at three different ages and gave three different patterns of development in the cells of abomasal mucosa. The number of cells producing prochymosin was closely correlated with milk-feeding, while the development of progastricsin was most related to the age of the calf. The most stable factor during the development of the cells in the abomasum was the number of cells producing pepsinogen.
Anat Rec 1990 Aug
PMID:Immunohistochemical studies on the development of cells containing progastricsin (minor pepsinogen) in comparison to prochymosin and pepsinogen in bovine abomasal mucosa. 211 12

Two outbreaks of parasitic gastroenteritis were observed in a group of 10 first-season grazing calves, one in mid-July and one in mid-September. In both cases emergency anthelmintic treatment was needed to prevent further damage. Severe clinical signs were observed together with high faecal egg counts and high serum pepsinogen and gastrin concentrations. Low total protein and albumin concentrations were also observed, especially during the second outbreak. The ostertagia antibody levels followed a similar pattern to the serum pepsinogen and gastrin concentrations. At the end of the housing period a mild type II ostertagiasis was observed. In the second grazing season the heifers did not show any signs of parasitic gastroenteritis, but there was a serious outbreak of husk which required treatment.
Vet Rec 1990 Oct 27
PMID:Observations on parasitic gastroenteritis and parasitic bronchitis in calves over two grazing seasons. 226 45

When they were turned out to grass in May 1987 for their first season, 10 calves were dosed with a 5 x 750 mg oxfendazole pulse release bolus (OPRB) and a monensin sodium rumen delivery device (RDD); eight calves received one OPRB; 10 calves received one RDD and eight calves received neither bolus. Each group was set-stocked on individual paddocks which had been grazed during the previous season by cattle which developed clinical parasitic gastroenteritis and bronchitis (husk). In July, before they were due to be moved to new pastures in mid-summer, and before they were dosed strategically with levamisole HCl, some of the calves not dosed with an OPRB succumbed to clinical parasitic gastroenteritis and husk and received emergency anthelmintic treatment, after which no further clinical episodes occurred. The 'dose and move' strategy was implemented in early August after which both groups not dosed with an OPRB were set-stocked together until the trial ended on October 14, 147 days after turn out. The two groups of calves which had received the OPRB were also moved to new pasture and set-stocked together until the end of the trial. No evidence of clinical helminthiases developed in either of the two groups of calves dosed with OPRBs and their faecal worm egg and larval counts, and plasma pepsinogen activities remained low. They gained significantly more weight than the two groups of calves not dosed with OPRBs (P less than 0.001). The bolus types were compatible and induced no untoward side-effects when used together.
Vet Rec 1989 Jul 15
PMID:Concurrent use of the oxfendazole pulse release bolus and the monensin rumen delivery device in young grazing cattle. 277 30

Two early season suppressive anthelmintic programmes, ivermectin given three, eight and 13 weeks after turn out and a morantel sustained release bolus administered at turn out, were compared on a commercial farm. The morantel treated cattle grew significantly faster than the ivermectin treated group during the period of treatment, on average at 0.80 kg/day compared with 0.71 kg/day (P less than 0.01). In the second half of the grazing season (13 to 25 weeks after turn out) the ivermectin treated group grew faster than the morantel treated group although the difference was not statistically significant. Over the entire grazing season there was no significant difference in average growth rate between the morantel treated group which grew at 0.80 kg/day and the ivermectin treated group which grew at 0.77 kg/day. These results were related to pasture larval counts, faecal egg counts and plasma pepsinogen levels throughout the grazing period. It was concluded that the morantel sustained release bolus allowed growing cattle to reach their production potential during the period of treatment. However, its efficacy in maintaining production throughout the grazing season was reduced by the 90 day treatment period which failed to give the level of control of gastrointestinal nematode parasites achieved by the 105 day period of treatment in the ivermectin programme.
Vet Rec 1989 Feb 04
PMID:Comparison of two early season anthelmintic programmes on a commercial beef farm. 292 2


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