Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The mutagenesis in phage T7 after MMS-, HNO2-, hydroxylamine-, 5-BUdR-, and 2-AP-treatment in relation to host controlled functions is investigated. There was no dependence of the induction of mutations on the character of the host strains (rec, hcr). A back mutation system (amber system) and a forward mutation system (host range system) have been used. Substances which cause mainly transitions from GC to AT do not lead or only rarely lead to reversions of the amber system; but chemicals producing transitions from AT to GC do so.
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PMID:Mutagenesis in bacteriophage T7. I. Chemically induced mutagenesis. 78 28

In order to develop a practical method for the construction of chiral molecules, we have designed a novel chiral reaction system possessing multi-metal centers utilizing tartaric acid ester as a chiral auxiliary. Based on this concept, we have developed an asymmetric 1,3-dipolar cycloaddition reaction of azomethine imines, an asymmetric hetero Diels-Alder reaction of nitroso compounds, an asymmetric Diels-Alder reaction of o-quinodimethanes. Furthermore, an asymmetric nucleophilic addition of alkynylzinc reagents, prepared in situ from dialkylzinc and 1-alkynes, to nitrones was achieved with high level of stereocontrol. In the last case, the addition of methylzinc salt of a product-like racemic hydroxylamine was found to be effective for unprecedented enhancement of enantioselectivity.
Chem Rec 2010 Jun
PMID:Recent progress in a chiral multinucleating system utilizing tartaric acid esters. 2050 6