Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The intravenous administration of xylazine (1.1 mg/kg bodyweight) in six ponies resulted in a significant increase in urine output over two hours, with maximum flow occurring between 30 and 60 minutes after injection. Urine specific gravity, osmolality and glucose concentration decreased. Renal clearance of endogenous creatinine was unchanged. Significant increases in the excretion of potassium and chloride occurred. Plasma glucose concentration was increased 30 minutes after the administration of xylazine by a mean value of 37 per cent. Serum osmolality and sodium, potassium and chloride concentrations remained unchanged.
Vet Rec 1986 Jan 18
PMID:Effects of xylazine on renal function and plasma glucose in ponies. 395 42

This paper reports seven cases of penile paraphimosis which occurred in both entire and castrated horses in association with general debility. Two cases were discharged after treatment while still suffering from partial paralysis; one was discharged at the owner's request with complete paralysis; three were destroyed and one died during treatment. Identified causes of debility were malnutrition, severe parasitism, glucose malabsorption and salmonellosis.
Vet Rec 1985 Feb 02
PMID:Paraphimosis in seven debilitated horses. 398 75

Eleven ewes with pregnancy toxaemia were monitored clinically and biochemically after daily treatment with trenbolone acetate (30 mg) and propylene glycol (twice daily 100 ml), for at least one week. The clinical signs of pregnancy toxaemia at first examination were less severe than those described in ewes in other countries. After the first treatment, the appetite improved in nine ewes, blood glucose levels increased in 10 ewes and blood ketone body concentrations decreased in nine animals. A statistically significant decrease in mean ketone body levels was found between the day of first examination and the second day thereafter. Four animals recovered before lambing (group 1). One animal lambed one day after the first treatment and recovered. In the remaining ewes clinical and biochemical improvement did not last long. Three of these animals did not recover until after lambing (group 2) and three animals died (group 3). In three animals of group 2 and two animals of group 3 an increase of serum activities of lactate dehydrogenase, sorbitol dehydrogenase, gamma glutamyl transferase and alkaline phosphatase was found. In two necropsied animals of group 3 a severe fatty degeneration of the liver was found. Treatment of pregnancy toxaemia with trenbolone acetate and propylene glycol appeared to have some positive effect in mild cases. In more advanced cases the time of parturition is the crucial factor leading to recovery.
Vet Rec 1985 Mar 16
PMID:Effects of trenbolone acetate and propylene glycol on pregnancy toxaemia in ewes. 399 31

Progressive, diabetes-associated ovarian atrophy was analyzed in C57BL/KsJ diabetic (db/db) and control (+/?) mice between 2 and 16 weeks of age. Tissue changes were histologically and morphometrically analyzed and compared with ovarian functional indices (i.e., serum estradiol and progesterone) and metabolic (i.e., glucose uptake and estradiol sequestration) parameters. No significant differences were found between the ovarian follicular populations of either group at 2 and 4 weeks of age. However, between 4 and 8 weeks, the ovaries of diabetic mice exhibited marked stromal and follicular degeneration and an associated decline in the population of viable follicles as compared with controls. Between 8 and 16 weeks of age the follicular atrophy in the diabetics became more marked, as compared with controls, with the accumulation of intracellular lipid pools accenting the tissue degeneration and adiposity observed in both follicular and stromal compartments. In addition, ovarian function was depressed after 6 weeks of age in diabetic females as compared with controls as indicated by lowered serum estradiol and progesterone levels. Ovarian glucose uptake was enhanced in diabetic females while the ability of the ovary to sequester radiolabeled estradiol declined between 4 and 16 weeks of age as compared with controls. These data indicate that ovarian dysfunction in the (db/db) mutant mouse is associated with follicular atrophy, adiposity, impaired steroidogenesis, and imbalanced glucose utilization. These events occur in temporal association with the onset and progressive exacerbation of the hyperglycemic condition. It is suggested that ovarian involution in these mutants is directly related to an impaired follicular ability to metabolize properly the elevated intracellular glucose concentrations that develop in the (db/db) mice as compared with controls.
Anat Rec 1985 Apr
PMID:Morphometric evaluation of diabetes-associated ovarian atrophy in the C57BL/KsJ mouse: relationship to age and ovarian function. 399 93

The medium in which Rec(+) strains of Escherichia coli K-12 are grown affected their sensitivity to treatment with methyl methane sulfonate (MMS). Rec(+) cells grown to the stationary phase in glucose-enriched nutrient broth (GNB) were more resistant to MMS than cells grown in nutrient broth (NB). The repair of MMS-induced breaks (or alkali-labile bonds) in the deoxyribonucleic acid (DNA) from E. coli K-12 strains AB1157, AB1886 uvrA6, and SR111 recA13 recB21 grown in GNB and NB media was examined by means of alkaline sucrose gradient centrifugation. It appeared that essentially all of the repair of breaks that occurred, as evidenced by an increase in "molecular weight," took place within 10 min after treatment with MMS under our conditions. Cell survival was highest in cells for which the size of the DNA after the post-treatment incubation was the largest. The largest DNA after post-treatment incubation was found in Rec(+) cells grown in GNB medium. The results suggest that these cells may have an enhanced capacity for repairing breaks in DNA.
 ...
PMID:Physiological modifications in the production and repair of methyl methane sulfonate-induced breaks in the deoxyribonucleic acid of Escherichia coli K-12. 434 30

The plasma concentration of glucose was monitored for six hours in lambs fed either ewe colostrum, cow colostrum or milk replacer by stomach tube at one hour of age. The feeding of ewe colostrum resulted in an elevation of the mean (+/- se) plasma glucose concentration from 2 . 6 +/- 0 . 3 mmol/litre before feeding to 7 . 3 +/- 0 . 92 mmol/litre three hours after feeding and this elevation was maintained. A similar rise was observed in the lambs fed cow colostrum but this was of shorter duration. A marked hyperglycaemia was observed after the feeding of milk replacer with a maximum value of 23 . 4 +/- 1 . 33 mmol/litre three hours after feeding. The practical implications of these results are discussed.
Vet Rec 1982 Nov 13
PMID:Effects of feeding ewe colostrum, cow colostrum or ewe milk replacer on plasma glucose in newborn lambs. 618 76

A glucose glycine electrolyte solution (GGES) was investigated to determine its suitability for oral rehydration in diarrhoea in pigs. Piglets with diarrhoea following experimental infection with eneteropathogenic Escherichia coli were given access in cube drinkers to either GGES or water. The mortality in the GGES group (11.6 per cent) was significantly (P less than 0.05) less than in the controls (24.0 per cent), and weight gain in severely diarrhoeic piglets was greater in the GGES group. Gnotobiotic piglets were challenged with pig rotavirus and either given access to GGES or milk. The GGES was either in restricted volume or ad lib. Restricted access to GGES prevented much of the weight loss due to the diarrhoea and ad lib access to GGES allowed relatively uninterrupted weight gain in comparison with controls. In naturally occurring cases of diarrhoea on farms, access to GGES reduced mortality to weaning from 19.7 per cent to 7.2 per cent (P less than 0.05). Weight gain per day was also greater in piglets which scoured for three days or more, indicating the rehydrating effect in reducing net fluid loss. Thus GGES treatment was of value in treatment e&ects of diarrhoea due to either E. coli or rotavirus.
Vet Rec 1980 Jan 26
PMID:Oral fluid replacement by a glucose glycine electrolyte formulation in E coli and rotavirus diarrhoea in pigs. 624 14

Glucose 6-phosphatase activity is higher in the principal cell than in other cell types in the terminal segment and caudal half of the middle segment of the mouse epididymis. Effect of castration and testosterone replacement on the high enzyme activity in the principal cell was studied in the terminal segment and the caudal half of the middle segment (cytochemical study), and in the whole epididymis (biochemical study). Ten, 20, or 30 days after castration, the abundant amount of reaction product seen in principal cells from intact control animals decreased to the level in basal cells, halo cells, and smooth muscle cells. However, in animals treated with testosterone following castration, the reaction product in principal cells remained abundant. Changes in the biochemical activity after castration or testosterone administration following castration paralleled the cytochemical results. Thus, the high activity in the principal cell is under the control of testosterone.
Anat Rec 1983 Oct
PMID:Effect of castration and testosterone replacement on high glucose 6-phosphatase activity in principal cells of the mouse epididymis. 631 10

The capability to synthesize recA protein has been tested for Escherichia coli treated with mitomycin C. recA protein was assayed using an immunoradiometric assay (Paoletti, C., Salles, B., and Giacomoni, P. U. (1982) Biochimie 64, 239-246). Mitomycin C-treated wild type E. coli can express recA gene in a similar quantitative fashion, independently of the growth media used in this work; glucose did not inhibit induction of recA protein in cells growing in synthetic media. Wild type E. coli recovering from energy starvation displays a similar qualitative capability to induce the synthesis of recA protein independently of the stage of growth at which the cells are treated with the drug. At midexponential phase, the cells appear to have an enhanced capability to synthesize recA protein. The relationship between survival and capability to synthesize recA protein was explored for E. coli lex, rec, and/or uvr mutants, after treatment with mitomycin C. A good correlation was found, except for a recB mutant and for an ethidium-sensitive strain, both able to produce as much recA protein as the wild type but 100-fold more sensitive to the drug. A similarly satisfactory correlation was found when plotting the survival after UV irradiation versus the capability of synthetizing recA protein with the exception of an uvrA strain and of a lexA strain.
 ...
PMID:Survival and induction of recA protein in mitomycin C-treated Escherichia coli rec, lex, or uvr strains. 641 32

A new system for the detection and treatment of hypothermia in newborn lambs was evaluated on 30 commercial farms. This system comprised the detection of hypothermia with the aid of an electronic thermometer, the reversal of hypoglycaemia in lambs aged more than five hours by an intraperitoneal injection of glucose solution, warming in air at 40 degrees C and careful management after warming. Of all lambs treated, 69 per cent were alive one week later. The majority of lambs which were treated and lived were subsequently reared on ewes. Treatment was more successful in lambs aged less than five hours (76 per cent) than in older lambs (64 per cent). Higher success rates were recorded when the hypothermia was detected in the temperature range of 37.0 to 39.0 degrees C (83 per cent) than when it was only detected at a temperature of less than 37.0 degrees C (65 per cent). Twins and triplet lambs were more susceptible to hypothermia than singles.
Vet Rec 1984 May 12
PMID:Effectiveness in commercial practice of a new system for detecting and treating hypothermia in newborn lambs. 646 9


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>