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Haematological and blood biochemical changes were studied in nine camels after maximal exercise over 4 or 5 km. There was a lack of splenic reserve for red blood cells, indicated by a minimal increase in haemoglobin concentration and haematocrit. There were marked increases in plasma lactate (to over 20 mmol/litre), plasma ammonia and plasma glucose and a pronounced decrease in circulating free fatty acids. There were small but significant increases in plasma calcium, magnesium, sodium, potassium, chloride and phosphate concentrations.
Vet Rec 1988 Sep 17
PMID:Effects of maximal exercise on the blood composition of the racing camel. 319 11

Newborn piglets were fed either a 5 per cent glucose/electrolyte solution or a commercial milk replacer for 24 or 36 hours before they were given colostrum, or they were given colostrum after birth. The effects of these treatments on their ability to absorb macromolecules was assessed by measuring the uptake of 125I-polyvinylpyrrolidone (125I-PVP) and the increases in the concentrations of total proteins and immunoglobulins in serum. The piglets which received colostrum at birth absorbed 50 per cent of a test dose of 125I-PVP within six hours, and there was a rapid increase in the concentration of immunoglobulins in their blood. The piglets which received the 5 per cent glucose/electrolyte solution absorbed 40 per cent of the test dose of 125I-PVP administered 24 or 36 hours after birth and nearly normal quantities of immunoglobulins, but the piglets given the milk replacer absorbed only 10 per cent of the test dose of 125I-PVP, and virtually no immunoglobulins.
Vet Rec 1988 Oct 08
PMID:Effect of feeding 5 per cent glucose solution or milk replacer to newborn piglets on intestinal permeability to macromolecules. 319 38

The haematological and biochemical changes associated with racing over 235 and 420 metres were studied in 23 greyhounds. Blood samples were collected while the dogs were resting and immediately after and 30 minutes after racing. Significant increases in red blood cell count, haemoglobin concentration and haematocrit occurred. The increase in haematocrit was accompanied by increases in total plasma protein and creatinine concentrations. Blood lactate increased to 11.4 and 13.2 mmol/litre over 235 and 420 metres, respectively, and plasma glucose increased to 7.9 and 8.2 mmol/litre. After the 420 metres, the mean plasma ammonia concentration was 256 mumol/litre. Plasma free fatty acid concentrations also increased after dogs had run both distances. The highest concentrations of glycerol and uric acid were found 30 minutes after exercise.
Vet Rec 1988 Nov 05
PMID:Changes in haematology and plasma biochemistry during maximal exercise in greyhounds. 320 94

We examined histochemically (light microscopy-LM) and cytochemically (electron microscopy-EM) the secretory epithelial cells in the tracheobronchial mucosa of sheep. Six morphologically distinct, granule-containing cells have been described, on the basis of their morphology and airway distribution: four mucous (M1-M4), serous (SC), and Clara (CC). Stereological and morphometric data indicated that M3, M4, SC, and CC were distinctly different from each other and from M1 and M2 cells. Mucous cells M1 and M2 differed in granule morphology. Samples of tracheas, sixth-generation bronchi, distal bronchi, and terminal bronchioles of 18 adult sheep were examined. At the LM level, methacrylate sections were reacted with an alcian blue (pH 2.5), periodic acid Schiff (PAS) sequence to differentiate neutral from acidic glycoconjugates (GC), and a high-iron diamine (HID), alcian blue sequence to differentiate sulfated from nonsulfated (sialylated) GC. At the EM level the periodic acid-thiocarbohydrazide localized hexose-rich, neutral GC. Dialyzed iron (DI) and high-iron diamine localized carboxylated and sulfated GC, respectively. Granules of all but Clara cells were PAS-positive. All mucous cells contained acidic groups, but only M1 and M4 cells had LM-detectable sulfated GC. At the ultrastructural level, minimal but discernible HID and LID reaction product was observed on granule profiles of M2, M3, and SC, indicating acidic and sulfated GC not detected at the LM level. Histochemically, the sheep tracheobronchial epithelium was more similar to that of humans than some other examined mammalian species.
Anat Rec 1988 May
PMID:Tracheobronchial epithelium of the sheep: III. Carbohydrate histochemical and cytochemical characterization of secretory epithelial cells. 338 36

A method for anaesthetising pregnant guinea pigs is described which makes one hour available for abdominal surgery and subsequent recovery; it uses a combination of fentanyl, fluanisone and diazepam with atropine, prednisolone and glucose saline. Provided anaesthesia was performed no later than the 48th day of gestation, 85 per cent of pregnancies continued to term and 74 per cent of the pups survived the first 24 hours after birth.
Vet Rec 1987 Nov 28
PMID:Anaesthesia in the pregnant guinea pig. 343 35

Post hibernational anorexia in captive Mediterranean tortoises is an increasingly recognised condition. It is associated with increased blood urea and low blood glucose concentrations and dehydration. A theory to explain its underlying physiology is presented, based on studies of the seasonal and cyclic variations in the tortoises' blood composition. Measurements useful for predicting the condition are identified and a logical approach to therapy is proposed.
Vet Rec 1987 Jan 24
PMID:Post hibernational anorexia in captive Mediterranean tortoises (Testudo graeca and Thermanni). 346 10

The effects of two glucocorticoid compounds (Dexamedium; Intervet. Voreen; Boehringer Ingelheim) were tested in 20 healthy and 28 ketotic dairy cows. Both compounds induced an increased blood glucose concentration and a temporary decrease in the milk yield of healthy dairy cows. Dexamedium reduced the milk yield only of cows producing 25 or more kg milk daily. Of 28 ketotic cows 22 were treated with one of the two glucocorticoid compounds, while the remaining six were treated orally with propylene glycol. After treatment all but one of the cows improved clinically within one week. Biochemical analysis of blood samples revealed that after treatment with any of the three therapeutic compounds some animals responded inadequately to therapy or relapsed after initial recovery.
Vet Rec 1987 Mar 28
PMID:Effects of two glucocorticoids on milk yield and biochemical measurements in healthy and ketotic cows. 359 May 63

To study the physiological role of skeletal muscle glycogen in starved animals, effects of starvation on glycogen and glycogen phosphorylase (EC 2.4.1.1.) activity were studied in muscle fibers (morphologic study) and in whole muscles (biochemical study) of the rectus femoris muscle of mouse. Glycogen content in the liver of the starved animals was also measured. PAS reaction, strong in muscle fibers of fed animals, became weak predominantly in type IIB fibers after 2 days and almost disappeared after 4 days of starvation. Glycogen particles, numerous in the sarcoplasm between myofibrils of muscle fibers, decreased markedly predominantly in type IIB fibers after 2 days and almost disappeared after 4 days. Phosphorylase a activity, undetected in fibers of fed mice, appeared weak in type IIB fibers and very weak in type IIA fibers after 2 days and became moderate in type IIB fibers and weak in type IIA fibers after 4 days. Muscle glycogen content did not differ by 16 hours from the values of corresponding fed animals. However, liver glycogen content had already decreased after 8 hours and markedly so after 12 hours. The results support our hypothesis-"skeletal muscle glycogen is used for maintaining the blood glucose level in starved mice" (Hirose et al.: Anat. Rec., 216:133-138, 1986)-and show that type IIB fibers play a main role in maintaining the glucose level and that muscle glycogen is utilized after depletion of liver glycogen.
Anat Rec 1987 Jul
PMID:Physiological role of skeletal muscle glycogen in starved mice. 363 41

Five standardbred geldings were given 1 mg/kg bodyweight of frusemide by intramuscular injection to induce mild dehydration. After food and water deprivation overnight, the mean weight loss was 24.4 +/- 1.8 kg (5.5 per cent of bodyweight). The horses were then given an equivalent volume of an oral glucose-glycine-electrolyte solution by stomach tube. No more than 10 litres was given every 30 minutes until the calculated bodyweight loss had been replaced. Measurements made before, during and after the fluid administration included bodyweight, arterial blood haematocrit, PCO2, pH, standard bicarbonate, base excess and plasma concentrations of sodium, potassium, chloride, total protein, glucose, urea and creatinine. The final measurement was taken eight hours after the last dose of fluid and no food or water was offered to the horses during this time. Administration of the solution caused a rapid correction of the frusemide-induced dehydration and metabolic alkalosis. Absorption of the fluid from the gastrointestinal tract appeared to be very rapid because by 30 minutes after the last dose of the solution, plasma protein values were not significantly different from those before administration of frusemide. Plasma glucose concentrations became significantly increased for up to three hours after the fluid was given and an increase in creatinine and urea concentrations, which was observed after the administration of frusemide, was still evident at eight hours. The glucose-glycine-electrolyte solution was well retained, there being a mean bodyweight loss of 2.8 kg at three hours and 6.2 kg at eight hours after the last dose of fluid.
Vet Rec 1986 Nov 22
PMID:An evaluation of an oral glucose-glycine-electrolyte solution for the treatment of experimentally induced dehydration in the horse. 381 Nov 59

Hyperlipaemia is an important condition in ponies, not just because of the seriousness of the clinical signs and biochemical changes involved, but because of the distress it causes owners and breeders that have had animals suffer from it. Hyperlipaemia occurs most commonly in fat ponies in late pregnancy and is rarely seen in larger horses. The syndrome has similarities with conditions in other species but the definitive aetiologies are not yet known. The condition in ponies is undoubtedly related to stress. The biochemical mechanisms involved in equine hyperlipaemia are considered and an hypothesis of possible pathogenesis is put forward. This hypothesis is tested by presenting the results of a preliminary study to evaluate glucose and lipid metabolism in horses and ponies. It appears that the pony is markedly insensitive to insulin compared to larger horses which means that triglycerides are more readily mobilised and the animal is therefore susceptible to hyperlipaemia in a situation of negative energy balance. The effect of stress is to increase cortisol levels which only exacerbates the insulin insensitivity and so creates a vicious circle. The importance of an innate insulin insensitivity may also be important in the pathogenesis of such conditions as laminitis.
Vet Rec 1985 Apr 27
PMID:Current concepts of hyperlipaemia in horses and ponies. 389 Mar 49


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