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The change in the localization of glucose 6-phosphatase activity within the liver lobule of the mouse was studied during development. From one day before birth to three days after birth, a uniform localization of the activity was observed throughout the lobule. This uniform localization of the acitvity gradually changed to that of the adult type, characterized by a relatively higher activity in periportal areas, between three to ten days of age. This indicates that the postnatal growth of the liver is accompanied by a change in the pattern of the localization of this enzyme activity within the liver lobule. Further, the biochemical results showed that the elevated activity after birth was reduced to the level seen in adult at ten days of age. Thus, the reduction in the level of the enzyme activity during ten days after birth corresponds to a redistribution of the enzyme activity within the liver lobule.
Anat Rec 1975 Mar
PMID:Postanal changes in the localization of glucose 6-phosphatase activity within the liver lobule of the mouse. 16 95

Subepicardial and subendocardial arteries and arterioles in both the left and right normal canine ventricle were examined histochemically to determine their metabolic profiles. Aerobic metabolic capacity was assessed by determining the reactivities of the enzymes cytochrome oxidase, succinate dehydrogenase and NAD-isocitrate dehydrogenase. Glucose-6-phosphate dehydrogenase was examined to assess activity of the hexose-monophosphate-shunt. The substrate glycogen was determined as an evaluation of anaerobic metabolic capacity, while the amounts of deoxyribonucleic and ribonucleic acid were assessed as an indication of protein synthesis. Results of the present investigation indicate that despite known hemodynamic differences, the metabolic profile of the coronary vasculature is similar in all regions of ventricular myocardium. Reactivities of the enzymes succinate and NAD-isocitrate dehydrogenase and cytochrome oxidase are greater in smooth muscle of arterioles than in arteries. This suggests that arteriolar smooth muscle has a higher capacity for aerobic metabolism than does arterial smooth muscle. The greater reactivity of glycogen in arterial, than in arteriolar smooth muscle, suggests that arterial muscle is more adapted for anaerobic metabolism. Deoxyribonucleic and ribonucleic acids demonstrate a low reactivity in both arteries and arterioles from all regions of ventricular myocardium which conforms to the opinion that under normal conditions, coronary vasculature is quite stable with little cell proliferation. Glucose-6-phosphate dehydrogenase shows little reactivity in all myocardial vessels with implies a low capacity for nucleic acid and protein synthesis.
Anat Rec 1978 Oct
PMID:A histochemical study of the microvasculature in the left and right cardiac ventricles of the dog. 21 88

Single, isolated pancreatic islets of mice and rats were incubated for varying time intervals (0.5-60) minutes with high (300 mg%) and low (50 mg%) levels of glucose. The structural integrity of islets decreased progressively with time regardless of glucose concentration. Degeneration of islets was greatest after 60 minutes of incubation. The total amount of insulin released from cytologically intact mouse islets incubated with high glucose levels was always greater than that with low glucose except following 30 seconds of incubation when no difference was observed. Peaks of insulin secretion noted after 2 and 15 minutes of incubation were correlated with light microscopic and fine structural changes indicative of active secretion in beta-cells, i.e., degranulation, granule margination. At 5 and 30 minutes of incubation many beta-cells contained enlarged Golgi zones and abundant profiles of swollen rough endoplasmic reticulum containing pale, amorphous granular material presumably indicating insulin synthesis. Emphasis is placed on the desirability of correlating physiological and biochemical studies of isolated pancreatic islets with cytologic examination.
Anat Rec 1977 Aug
PMID:Cytophysiological studies on isolated pancreatic islets in vitro. 33 11

Carotid bodies from adult rats were electron microscopically studied after incubation in glucose-containing salt solutions containing calcium and/or ionophore A23187 or neither. In the absence of the ionophore, adding or omitting calcium had no effect on the fine structure of the glomus cells. Incubation in the medium containing both 1 mM calcium and the ionophore caused the appearance of exocytotic membrane profiles in several glomus cells. Exocytosis was not seen when only A23187 and endogenous calcium was present. For exocytosis to occur, calcium appeared to be essential and the event seemed to be due to a rise in the intracellular calcium concentration caused by the ionophore.
Anat Rec 1979 Oct
PMID:Induction of exocytosis from glomus cells by incubation of the carotid body of the rat with calcium and ionophore A23187. 38 92

The relative effectiveness of implanting 300 mg trenbolone acetate alone or in combination with either 15, 30 or 45 mg hexoestrol was studied in three 90-day experiments using 64 Friesian steers. In experiment 1 hexoestrol was shown to improve live-weight gain and efficiency of feed conversion in steers implanted with trenbolone acetate. In experiments 2 and 3 trenbolone acetate in combination with 30 mg hexoestrol gave a better growth response than when combined with either 15 or 45 mg. However, in experiment 3 trenbolone acetate plus 15 mg hexoestrol was shown to improve live-weight gain by about 36 per cent compared with untreated controls. In experiment 2 small differences between treated groups in mean values for plasma urea, serum albumin, plasma glucose and free fatty acids were recorded.
Vet Rec 1979 Sep 22
PMID:Effect of hexoestrol on the response of finishing steers to treatment with trenbolone acetate. 51 14

The effect of xylazine and xylazine followed 20 minutes later by insulin upon glucose metabolism and plasma insulin concentrations was examined in three cows. After doses of 0.18 mg per kg xylazine given intramuscularly (IM) or 0.15 mg per kg given intravenously (IV) hepatic glucose production increased, plasma insulin concentrations decreased to 25 to 33 per cent of control values, and there was a prolonged hyperglycaemia. When 200 units of soluble insulin were given 20 minutes after similar doses of xylazine there was a rapid fall in blood glucose and a reduction in the rate of glucose production by the liver. Xylazine-induced hyperglycaemia arose from a combination of increased hepatic glucose production and reduced plasma insulin concentrations. Peripheral tissues were still responsive to insulin and when adequate insulin was available blood glucose concentrations rapidly decreased.
Vet Rec 1978 Jan 14
PMID:The effect of xylazine and xylazine followed by insulin on blood glucose and insulin in the dairy cow. 63 10

Blood samples were taken from 15 horses before and after a 50-mile ride to examine the changes occurring in some biochemical constituents. There was a significant (P less than 0.05) decrease in plasma potassium, calcium and magnesium concentrations and a rise in inorganic phosphate but there was no alteration in plasma sodium, chloride or protein levels or change in haematocrit. After the ride there was a highly significant (P less than 0.01) fall in blood glucose corresponding with increased lipolysis and a rise in plasma free fatty acids (P less than 0.001) and glycerol (P less than 0.001). There was a modest increase in blood lactate and a rise in plasma creatine phosphokinase. The results of this preliminary investigation are discussed in relation to the problem of exhaustion in horses during endurance rides.
Vet Rec 1978 Apr 22
PMID:Biochemical changes in horses during a 50-mile endurance ride. 65 49

Twenty British Friesian steers were divided into four uniform groups and either not treated or implanted with hexoestrol, trenbolone acetate, or hexoestrol plus trenbolone acetate. Hexoestrol was given 90 days and trenbolone acetate 70 days, before slaughter. Animals in the treatment groups grew significantly faster, converted food to live-weight gain more effciently faster, converted food to live-weight gain more efficiently and had lower levels of plasma urea and to a lesser extent serum albumin than untreated controls for the final 70 days before slaughter. The combined treatment of hexoestrol plus trenbolone acetate produced more pronounced effects than either compound given alone. Steers treated with hexoestrol had significantly greater levels of serum growth hormone than steers implanted with trenbolone acetate alone or untreated controls, but the treatments had no significant effect on levels of plasma glucose, free fatty acids or serum insulin. Carcase conformation and fat cover assessed subjectively did not differ between treated and control animals but killing out percentage was generally higher in all treatment groups.
Vet Rec 1978 Jul 08
PMID:Performance, blood and carcase characteristics of finishing steers treated with trenbolone acetate and hexoestrol. 68 99

Blood samples were taken from ketotic cows and from normal lactating cows in summer and winter. The lowest serum growth hormone and plasma glucose levels and the highest serum free fatty acid values were observed in the ketotic cows. It is suggested that the decrease in growth hormone might benefit the ketotic animal.
Vet Rec 1977 Jul 09
PMID:Bovine serum growth hormone levels in clinical ketosis. 90 18

Blood chemistry, nutrition, productivity and fertility were monitored and their interrelationship examined in groups of cows from 15 commercial dairy herds. Plasma urea, albumin, glucose, non-esterified fatty acids (NEFA), acetone, calcium, magnesium, inorganic phosphorus (IP), blood copper, haemoglobin and packed cell volume were examined in relation to the intakes of starch equivalent (SE) digestible crude protein (DCP), calcium, phosphorus, magnesium, sodium, potassium, copper and manganese. The most consistent correlations were found for the regressions of SE intake as a percentage of requirements (I/R per cent) on plasma non-esterified fatty acids, the ratio of SE intake over DCP intake on plasma urea, DCP I/R per cent on plasma urea and phosphorus I/R per cent on plasma IP, but factors other than nutrition accounted for a large part of the variation in all cases. The mean plasma glucose concentration within +/- three days before or after first service of cows which held was higher than that of cows which returned, but the difference was only approaching significance at the 5% level and it is doubtful whether it could be of practical value. No other differences in blood component levels were demonstrated for first or second service. It is concluded that, within the nutritional ranges encountered, the levels of the selected blood components did not show a consistent relationship to nutrient balance or potential fertility. In this context a multiple analytical scheme employing these components would appear to be of limited value, particularly if samples are taken on only one occasion. The technique is more appropriately regarded as an aid to the conventional approach involving the examination of feeding systems and feedstuffs, herd records, management and clinical conditions.
Vet Rec 1976 May 15
PMID:Investigations into the relationship of selected blood components to nutrition and fertility of the dairy cow under commercial farm conditions. 93 47


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