Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mammary tumour tissue from two bitches and an anal adenoma from a dog were investigated for steroid receptor interaction. Both mammary tumours possessed cytoplasmic macromolecules sedimenting with coefficients of 4S and 8S that bound oestradiol-17beta. These receptors had molecular weights of approximately 60,000 and 180,000 respectively. Transfer of the oestrogen to the nucleus was shown and the presence of a 4-5S nuclear protein demonstrated. The anal adenoma had a cytoplasmic receptor, with a sedimentation value in a sucrose density gradient of 4-5S with respect to bovine serum albumin, that bound tritiated 5alpha-androstane-3alpha, 17alpha-diol. No affinity could be demonstrated for other C19-steroids examined. The significance of these findings in terms of the hormone dependence of the tumours investigated and the possible development of these studies to promote rational therapy in such cases is discussed.
Vet Rec 1975 Dec 13
PMID:Tissue-steroid interactions in canine hormone-dependent tumours. 17 72

The effects of 5alpha-androstane-3alpha, 17beta-diol (3alpha-diol) and 5alpha-androstane-3beta, 17beta-diol (3beta-diol) were studied in rats hypophysectomized and treated daily for 30 days with the steroids, starting on the day of surgery (hypophysectomized, H) or 30 days following the removal of pituitary (hypophysectomized regressed, HR). The ability of 3beta-diol to maintain and restimulate the prostate glands and seminal vesicles of castrated (C) and castrated regressed (CR) rats, respectively, was also studied. This androgen (3beta-diol) was able to maintain as well as rejuvenate to some degree the sexual accessory glands of all treatment groups. The prostate glands and seminal vesicles in both castrated experimental groups showed increased stimulation with progressively higher dosages of 3beta-diol. At all dose levels, stimulation of seminal vesicles of CR rats was comparable to that of non-regressed castrates. The prostate glands, on the other hand, showed better maintenance in the higher dosage group. In H rats, the stimulation of sexual accessory glands by both androgens was not significantly different than normal controls. The seminal vesicles and prostate glands of HR rats treated with 3alpha-diol were well stimulated and comparable to those of H rats treated with 3alpha-diol. The seminal vesicles of HR rats treated with 3beta-diol were also well stimulated, though not to the extent as those with 3alpha-diol treatment. The prostate glands of the 3beta-diol treated HR rats were significantly smaller than those of the 3alpha-diol treatment group. However, these miniature glands were morphologically stimulated as evidenced by mitosis of parenchymal cells and accumulation of secretory products in the alveoli. This study clearly indicates that 3beta-diol is biologically active and the degree of stimulation varies with the animal preparation in which the androgens were tested.
Anat Rec 1978 Dec
PMID:The effects of 5alpha-reduced androgens on maintenance and regeneration of prostate glands and seminal vesicles in castrated and hypophysectomized rats. 73 74