Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present paper reviews the main features of amelogenin and enamelin biochemistry, molecular biology, structural and ultrastructural localization, and immunology. It also examines recent studies concerning the origin, chemical characterization, suggested role, and participation of these two major classes of extracellular developing enamel matrix proteins in the complex process of "matrix-mediated" mineralization.
Anat Rec 1989 Jun
PMID:Structure and function of enamel gene products. 267 84

Amelotin is expressed and secreted by ameloblasts in tooth development, but amelotin distribution during enamel development is not clear. In this report, we first investigated amelotin expression in developing teeth by immunohistochemistry. Amelotin was detected in the enamel matrix at the secretion and maturation stages of enamel development. Amelotin was also observed at Tomes' processes on the apical ends of secretory ameloblasts. We then compared amelotin gene expression with those of amelogenin, enamelin, and ameloblastin in the mandibles of postnatal mice by RT-PCR. The expression of amelotin was detected as early as in postnatal day 0 mandibles and amelotin was coexpressed with amelogenin, ameloblastin, and enamelin during tooth development. These data strongly suggest that amelotin is an enamel matrix protein expressed at the secretion and maturation stages of enamel development.
Anat Rec (Hoboken) 2010 Jan
PMID:Distribution of amelotin in mouse tooth development. 1993 42