Gene/Protein Disease Symptom Drug Enzyme Compound
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This study deals with the applicability of Araldite F as injection medium for quantitative morphology of the cerebral vascularization. The physical properties of the plastic that are essential for obtaining optimal results have been determined and tested by injection into the cerebral vessels of ten dog brains and five human brains. The dynamic viscosity (at 20 degrees C) of the plastic is 1.5 times that of blood. The polymerization time (+/- 45 min) is long enough to fill the whole vascular tree in a large organ such as the human brain. The plastic shows minimal volume shrinkage (3.90% +/- 0.05%), and the final cast is suitable for scanning electron microscopy (SEM) investigation after corrosion and histological morphometrical examination after embedding in 2-hydroxyethyl-methacrylate (GMA). Special attention has been paid to the conditions under which injection of Araldite F into the cerebral arteries must take place to obtain the most accurate quantitative data on cerebral vascularization and vascular area distribution. Simultaneous injection of the major cerebral arteries of fresh autopsy material, after having removed blood clots by perfusing Kabikinase, is recommended.
Anat Rec 1990 Oct
PMID:Araldite F as injection material for quantitative morphology of cerebral vascularization. 224 Jun 16

In this paper a technique is described, using Araldite CY 223 and hardener HY 2967 as injection material, for preparing corrosion casts or histological sections. The plastic has a viscosity (at 39-40 degrees C) similar to that of blood, a gelling time of approximately 17 min (at 40 degrees C), and an exothermic transition energy of delta H = 80.28 +/- 3.20 cal/gm. The influence of the plastic on the tissue is discussed. The histological sectioning of fixed tissue containing Araldite-filled blood vessels after embedding in 2-hydroxyethyl-methacrylate (GMA) is described. When using GMA in a modification of the mixtures of Ruddell (1967) and Sims (1974), methylbenzoate is recommended as an intermedium in order to obtain a more uniform infiltration and reproducible section thickness. At the same time methylbenzoate is recommended as a storing fluid. Sections of 2-3 micrometers afford satisfying morphologic and morphometric results. This method allows various arterial wall dimensions to be measured easily, and provides a suitable means to compare histometric values with SEM data derived from corrosion casts.
Anat Rec 1982 Jun
PMID:A new plastic for morphometric investigation of blood vessels, especially in large organs such as the human liver. 711 2

The antimicrobial properties of N-(2-hydroxyethyl)-1,2-benzisothiazol-3(2H)-thione (1a,b) and its carbamic esters 2a,b-6a,b were tested in vitro against Gram positive and Gram negative bacteria, yeasts and dermatophytes. All compounds markedly inhibit the growth of Gram positive bacteria exhibiting MIC values ranging from 1.25 to 10 micrograms/ml. A strong antifungal activity is exerted against dermatophytes with MICs, in general, between 0.7 and 12 micrograms/ml. Structure-activity relationship studies show that these compounds are, in most cases, more effective than the corresponding benzisothiazolone analogues 7-12. None of the tested compounds shows genotoxic properties by Bacillus subtilis rec-assay and Salmonella-microsome test.
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PMID:Antimicrobial and genotoxic activities of N-(2-hydroxyethyl)-1,2-benzisothiazol-3(2H)-thione carbamic esters. 1057 31