Gene/Protein Disease Symptom Drug Enzyme Compound
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After treatment with various chemical and physical agents, flattened or ring-like saccules may occur in the cytoplasm of parietal cells of the gastric glands of several species of mammals. In the current investigation, similar structures appeared after treatment with high dosages of diazo-oxo-norleucine (DON), a glutamine antagonist. A tentative sequence for their formation is suggested. Saccules formed of unit membrane became abundant in some parietal cells of the treated mice. Single saccules often had narrow lumens and peripheral distensions. The saccules, either singular or several stacked together, became progressively more curved, enclosing a region of cytoplasm that often contained glycogen-like particles and occasionally vesicles or other organelles. Many of the concentric saccules were close to an intracellular canaliculus. Membrane bound cytoplasm containing glycogen-like particles occasionally occurred in the canaliculi, suggesting that exocytosis had occurred. Cytochemistry revealed that glycoproteins were associated with the concentric saccules, probably located on the luminal surface. The glycogen-like particles in all locations stained in a manner characteristic of glycogen. It is suggested that the concentric saccules may form from vesicles of the tubulovesicular system.
Anat Rec 1979 Apr
PMID:Formation of concentric saccules in murine parietal cells after injection of diazo-oxo-norleucine. 21 77

Tubular structures were observed in surface epithelial cells of mice that had been injected with high dosages of diazo-oxo-norleucine (DON), a glutamine antagonist. The tubules often occurred in bundles which contained a variable number of tubules, often as many as one hundred being present. Within the bundles, the tubules were oriented either randomly or parallel to one another. They measured 25 to 35 nm in diameter with angular or circular profiles and were as long as 1 to 2 micron. In the center of each tubule, a small tubule-like component was evident that measured 5 to 7 nm in diameter. With the exception of endoplasmic reticulum, often with attached ribosomes, organelles were excluded from the bundles. Since the tubules and the endoplasmic reticulum occasionally were observed to be continuous, it is suggested that the tubules may originate from this organelle.
Anat Rec 1980 Aug
PMID:The occurrence of an unusual tubular organelle in surface epithelial cells of the mouse ascending colon after injection of diazo-oxo-norleucine. 721 94

Tubular structures were observed in surface epithelial cells of mice that had been injected with high dosages of diazo-oxo-norleucine (DON), a glutamine antagonist. The tubules often occurred in bundles which contained a variable number of tubules, often as many as one hundren being present. Within the bundles, the tubules were oriented either randomly or parallel to one another. They measured 25 to 35 nm in diameter with angular or circular profiles and were as long as 1 to 2 micron. In the center of each tubule, a smaller tubule-like component was evident that measured 5 to 7 nm in diameter. With the exception of endoplasmic reticulum, often with attached ribosomes, organelles were excluded from the bundles. Since the tubules and the endoplasmic reticulum occasionally were observed to be continuous, it is suggested that the tubules may originate from this organelle.
Anat Rec 1980
PMID:The occurrence of an unusual tubular organelle in surface epithelial cells of the mouse ascending colon after injection of diazo-oxo-norleucine. 739 31

Caprine efferent ductule epithelium contains ciliated and nonciliated cells. The latter cells are divided into three types: type II cells contain PAS-positive granules, type III cells contain PAS-negative vacuoles, and type I cells lack both granules and vacuoles (Goyal and Williams, Anat. Rec. 220:58-67). The objectives of this study are i) to determine when the epithelium differentiates into ciliated and nonciliated cells, ii) to determine when nonciliated cells acquire characteristics typical for type II and type III cells, and iii) to relate developmental changes in the epithelium with those in the testis. Testes and efferent ductules were examined at the light and electron microscopic levels in goats from 1-25 weeks of age. Efferent ductule epithelium contained ciliated and nonciliated cells as early as week 1. While ciliated cells were differentiated at week 1, differentiation of nonciliated cells did not occur until week > or =15. Differential features in ciliated cells included the presence of cilia at the apical border and an aggregation of mitochondria in the apical cytoplasm. Those in nonciliated cells included the presence of i) an endocytotic apparatus at week > or =15, ii) PAS-positive granules at week > or =15, and iii) PAS-negative vacuoles at week > or =25. The seminiferous tubules developed lumens at 12-15 weeks. Hence, while differentiation of ciliated cells occurred much before lumen formation in the seminiferous tubules, that of nonciliated cells coincided with, or occurred soon after, lumen formation, suggesting a role for testicular fluid contents in their differentiation. The goat efferent ductules can be characterized morphologically mature by 25 weeks.
Anat Rec 2000 05 01
PMID:Postnatal differentiation of efferent ductule epithelium in goats: a light microscopic and ultrastructural study. 1076 Jul 38