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Query: UNIPROT:Q9UIJ5 (Rec)
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Thiophanate administered daily at low dosages reduced nematode faecal egg output, egg hatchability and parasitic worm burdens in treated lambs and ewes. Six daily doses of 1 or 3 mg per kg thiophanate (approximately 1/25th to 1/75th of the median therapeutic dose), given to lambs experimently infected with Trichostrongylus colubriformis, were partially effective in suppressing faecal egg output and egg hatchability. Six doses of 5 mg per kg per day were effective in lambs infected with Haemonchus contortus and Nematodirus spathiger. Daily doses of thiophanate (50 or 200 mg per head) given over 14 weeks to lambs grazing contaminated pasture resulted in improved productivity (the higher dosage) and suppression of output of viable eggs and reduced worm burdens (both dosages). Reduced output of viable eggs was also obtained in housed, lactating ewes receiving 5 or 7 mg per kg thiophanate dispersed daily in the feed for 11 or nine weeks respectively after lambing.
Vet Rec 1978 Aug 12
PMID:Thiophanate as a low daily dosage anthelmintic in sheep. 69 54

Productivity and tolerance trials were conducted with the anthelmintic thiophanate (Nemafax; May & Baker) in sheep in the United Kingdom. Tolerance studies, conducted in sheep of various types under several management systems, in which thiophanate was given orally at recommended dosage (50 to 100 mg/kg), or multiples thereof, in single or repeated doses showed that treatment was in all cases well tolerated. Thiophanate administered at 75 mg per kg or 250 mg per kg to groups of growing lambs with low faecal egg counts produced no post treatment depression of weight gain. When breeding ewes were treated with thiophanate at 150 mg per kg on days 14, 21 and 28 after introduction of rams to the flock, the anthelmintic produced no adverse effect on lambing performance. Trials to assess the beneficial effects of treatment were conducted in weaned lambs naturally infected with gastrointestinal nematodes. Groups of lambs were treated monthly with either thiophanate or tetramisole at recommended dosages. The two anthelmintics produced similar weight gains in the lambs and these were significantly better than those of untreated controls. In untreated controls faecal egg counts increased markedly and the clinical condition of these animals deteriorated.
Vet Rec 1977 Mar 12
PMID:Field trials in sheep with the anthelmintic thiophanate. 85 2

Thiophanate, administered at a dosage of 50 mg per kg to artifically infected pigs, removed 96 to 99 per cent of adult Oesophagostomum spp, Hyostrongylus rubidus and Trichuris suis. Activity was also high against larval stages of these nematodes, except for 26-day-old T suis. Thiophanate also showed ovicidal and larvicidal activity against H rubidus and Oesophagostomum spp. At 50 mg per kg thiophanate administered alone was inactive against Ascaris suum and Metastrongylus apri, the former species also being refractory at 200 mg per kg. Field trials confirmed these efficacy results in naturally infected animals. Pellet formulations providing mean dosages of 63 mg thiophanate per kg for adult pigs and 75 mg thiophanate per kg with 83 mg piperazine base per kg for growing pigs were highly effective in reducing the faecal output of Oesophagostomum spp, H rubidus and T suis eggs. In growing pigs, A suum was controlled by the thiophanate/piperazine product. No palatability or tolerance problems were observed when thiophanate or thiophanate/piperazine mixtures were administered at recommended dosage or multiples thereof in experimental or field studies.
Vet Rec 1976 Aug 14
PMID:Experimental and field studies with thiophanate in pigs. 96 96