Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
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In a farm-scale veterinary preventive programme run from 1973 to 1976 the use of rafoxanide (Flukanide; Merck Sharp & Dohme) in the prophylaxis of ovine fascioliasis resulted in a marked reduction in the percentage of ewes passing fluke eggs in the faeces and an absence of clinical cases of fascioliasis throughout these years. Three separate flocks of hill sheep were used in this study in which the aim of the dosing programme followed was to kill the majority of liver flukes (Fasciola hepatica) before they reached adult egg laying stage, thereby eliminating, or considerably reducing, the number of eggs passed on to the pasture.
Vet Rec 1977 May 21
PMID:A study of a strategic dosing programme against ovine fascioliasis on a hill farm. 87 50

In two trials the fasciolicidal activities of triclabendazole, nitroxynil and rafoxanide were assessed in cattle naturally infected with predominantly immature stages of Fasciola hepatica. Tablets containing 900 mg triclabendazole were administered orally at a dose rate of 12 mg/kg bodyweight. Rafoxanide and nitroxynil were used at a dose rate of 10 mg/kg, rafoxanide being given orally and nitroxynil by subcutaneous injection. Based on faecal egg counts nine weeks after treatment the efficacies were calculated to be 100 per cent for triclabendazole and 95.0 per cent for nitroxynil in the first trial and 98.4 per cent for triclabendazole and 52.9 per cent for rafoxanide 15 weeks after treatment in the second trial. In the first trial five animals from each of the three groups were slaughtered and their fluke burdens counted. Compared with the untreated control group the reductions in the fluke burdens were 96.9 per cent in triclabendazole treated cattle and 76.4 per cent in the nitroxynil treated group.
Vet Rec 1988 Jan 16
PMID:Comparative efficacy of triclabendazole, nitroxynil and rafoxanide against immature and mature Fasciola hepatica in naturally infected cattle. 335 56