Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thiophanate, administered at a dosage of 50 mg per kg to artifically infected pigs, removed 96 to 99 per cent of adult Oesophagostomum spp, Hyostrongylus rubidus and Trichuris suis. Activity was also high against larval stages of these nematodes, except for 26-day-old T suis. Thiophanate also showed ovicidal and larvicidal activity against H rubidus and Oesophagostomum spp. At 50 mg per kg thiophanate administered alone was inactive against Ascaris suum and Metastrongylus apri, the former species also being refractory at 200 mg per kg. Field trials confirmed these efficacy results in naturally infected animals. Pellet formulations providing mean dosages of 63 mg thiophanate per kg for adult pigs and 75 mg thiophanate per kg with 83 mg piperazine base per kg for growing pigs were highly effective in reducing the faecal output of Oesophagostomum spp, H rubidus and T suis eggs. In growing pigs, A suum was controlled by the thiophanate/piperazine product. No palatability or tolerance problems were observed when thiophanate or thiophanate/piperazine mixtures were administered at recommended dosage or multiples thereof in experimental or field studies.
Vet Rec 1976 Aug 14
PMID:Experimental and field studies with thiophanate in pigs. 96 96

A controlled trial was performed to evaluate the efficacy of piperazine dihydrochloride in a new granular formulation (Ascarex D) against naturally occurring infections with Ascaris suum, Oesophagostomum dentatum and O quadrispinulatum. Treatment effects were estimated on the basis of parasites recoverable from the intestinal contents. Given orally at 200 mg per kg body weight the compound showed an efficacy of 99 to 100 per cent against A suum and the nodular worms. Egg excretion of the respective species was reduced by 98 per cent and 100 per cent six days after treatment. No adverse reactions were observed after the treatment.
Vet Rec 1988 Jul 30
PMID:Efficacy of piperazine dihydrochloride against Ascaris suum and Oesophagostomum species in naturally infected pigs. 304 12

The presence of benzimidazole-resistant strains of equine small strongyles was confirmed in horses at two properties in north west England by a series of faecal egg counts and larval cultures after treatment with mebendazole. A trail formulation of mebendazole in combination with piperazine citrate gave greater reductions in faecal egg counts than mebendazole alone but was much less effective than pyrantel embonate or dichlorvos.
Vet Rec 1988 Aug 27
PMID:Experimental chemotherapy in horses infected with benzimidazole-resistant small strongyles. 317 82

Clinical trials were carried out to test the safety and efficacy of the anthelmintic, nitroscanate, against naturally acquired helminth infections. The trials involved 418 dogs, of which 252 were treated with one or other of two different tablet formulations of nitroscanate. A coarse particle formulation given in two doses each of 200 mg per kg reduced the worm burden of Taenia spp and Dipylidium caninum by 100 per cent and Echinococcus granulosus by 94.1 per cent in farm dogs. Given as a single dose of 100 mg per kg this formulation reduced faecal worm egg counts by 95.3 per cent for Toxocara canis, 93.3 per cent for Toxascaris leonina and 99.1 per cent for Uncinaria stenocephala. A micronised formulation given in a single dose of 50 mg per kg caused a 97.9 per cent reduction in worm burden for Taenia spp and D caninum and 98.3 per cent reduction for E granulosus in foxhounds. The same formulation at this dosage gave reductions in faecal worm egg counts of 96.4 per cent for T canis and 100 per cent for T leonina and U stenocephala. Side-effects recorded were fewer than with piperazine and bunamidine.
Vet Rec 1980 Apr 12
PMID:Field trials with nitroscanate against cestodes and nematodes in dogs. 699 May 96

One hundred and forty mice were infected orally with 1000 embryonated Toxocara canis eggs. Groups of 10 mice were then treated with high doses of piperazine, mebendazole, oxfendazole, albendazole, fenbendazole and diethylcarbamazine for four days, either immediately after infection or three weeks after infection. The mice were killed three to six weeks after treatment and the number of larvae in the brains and muscles estimated and compared with those in untreated mice. Few larvae were recovered from the muscles of any of the mice, including the untreated controls, despite the use of a variety of recognised techniques. Large numbers of live larvae were recovered from the brains of the mice and there was no significant difference between the treated and untreated mice.
Vet Rec 1981 Apr 04
PMID:Anthelmintic tests on Toxocara canis infection in mice. 723 81

In a series of controlled trials involving 59 naturally infected greyhounds, fenbendazole at a dose rate of 50 mg/kg/day for three consecutive days reduced the overall numbers of third and fourth stage Toxocara canis by 94.0 per cent and third stage, fourth stage and immature adult stages of Toxascaris leonina by 92.4 per cent. In contrast, piperazine at 100 mg/kg had little or no useful effect against the larval stages of T canis and T leonina and variable efficacy against immature adult T leonina. Fenbendazole was also 100 per cent effective against immature Trichuris vulpis. In a separate controlled experiment, puppies in three litters exposed to reinfection with T canis were treated with fenbendazole at two weeks old and again only after their mean faecal egg counts exceeded 200 epg. Between one and three doses were required to suppress the output of eggs during the puppies' first 12 weeks of life.
Vet Rec 1993 May 08
PMID:Efficacy of fenbendazole and piperazine against developing stages of toxocara and toxascaris in dogs. 850 98