Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Specimens from cattle and sheep suspected of having cerebrocortical necrosis (CCN) were studied. Rumenal contents were examined for thiaminase-producing bacteria. Thiaminase activity was assessed in rumenal contents. The thiamine concentration of liver, brain and heart was determined and erythrocyte transketolase assessed. Diagnosis in each case, whether positive or negative for CCN, was decided by histopathological examination. There was a substantial agreement between the biochemical findings and the histological diagnosis indicating that a provisional diagnosis may be made on clinical and biochemical data alone. The findings are discussed in relation to other diseases which have the same neuropathological features. Attempts to isolate thiaminase-producing bacteria, which may be implicated in the aetiology of CCN, were inconclusive.
Vet Rec 1979 Jan 06
PMID:Diagnostic aspects of cerebrocortical necrosis. 43 5

Large numbers of orally inoculated thiaminase type 1-producing Clostridium sporogenes failed to establish in the alimentary tract of two conventionally born lambs. Conversely, when similar inoculations were given to two gnotobiotic lambs, large populations of Cl sporogenes established in their rumens and correspondingly high levels of thiaminase were produced. No clinical symptoms of thiamine deficiency or cerebrocortical necrosis were seen despite the presence of high levels of thiaminase in the rumen of one of the gnotobiotic lambs for a period of 86 days.
Vet Rec 1979 Nov 24
PMID:Cerebrocortical necrosis in ruminants: effect of thiaminase type 1-producing Clostridium sporogenes in lambs. 53 76

Polioencephalomalacia (PEM) was induced in sheep, with an overall incidence of 63 per cent, using local bracken fern (Pteridium esculentum) rhizomes as a source of thiaminase type 1 and pyridine as a basic cosubstrate. The condition was thiamin responsive and PEM was confirmed by histopathological examination. In a separate experiment to examine the effect of pyridine, it was shown that, for the duration of the experiment, pyridine had no toxic effect and caused no histologically detectable brain lesions.
Vet Rec 1980 Nov 15
PMID:Experimental induction of ovine polioencephalomalacia. 744 44