Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty calves were infected with 1000 metacercariae of Fasciola hepatica, the activities of 10 enzymes in plasma or serum were assayed and concentrations in serum of proteins, urea and bilirubin were determined. These values were compared with control data obtained from 14 uninfected calves. Aspartate aminotransferase, lactate dehydrogenase, sorbitol dehydrogenase, glutamate dehydrogenase, ornithine carbamoyl transferase and gamma-glutamyl transpeptidase activities increased in infected calves. Total serum protein increased, albumin decreased, globulin increased and the albumin/globulin ratio was decreased in infected calves. Plasma alanine aminotransferase, leucine aminopeptidase, alkaline phosphatase and cholinesterase activities and serum concentration of urea and bilirubin were unaffected. It was concluded that glutamate dehydrogenase and gamma-glutamyl transpeptidase were the most sensitive indicators of liver cell damage in fascioliasis.
Vet Rec 1977 Jan 15
PMID:Biochemical indicators of liver injury in calves with experimental fascioliasis. 83 11

Eleven ewes with pregnancy toxaemia were monitored clinically and biochemically after daily treatment with trenbolone acetate (30 mg) and propylene glycol (twice daily 100 ml), for at least one week. The clinical signs of pregnancy toxaemia at first examination were less severe than those described in ewes in other countries. After the first treatment, the appetite improved in nine ewes, blood glucose levels increased in 10 ewes and blood ketone body concentrations decreased in nine animals. A statistically significant decrease in mean ketone body levels was found between the day of first examination and the second day thereafter. Four animals recovered before lambing (group 1). One animal lambed one day after the first treatment and recovered. In the remaining ewes clinical and biochemical improvement did not last long. Three of these animals did not recover until after lambing (group 2) and three animals died (group 3). In three animals of group 2 and two animals of group 3 an increase of serum activities of lactate dehydrogenase, sorbitol dehydrogenase, gamma glutamyl transferase and alkaline phosphatase was found. In two necropsied animals of group 3 a severe fatty degeneration of the liver was found. Treatment of pregnancy toxaemia with trenbolone acetate and propylene glycol appeared to have some positive effect in mild cases. In more advanced cases the time of parturition is the crucial factor leading to recovery.
Vet Rec 1985 Mar 16
PMID:Effects of trenbolone acetate and propylene glycol on pregnancy toxaemia in ewes. 399 31