Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The antirecombinant interleukin 2 (rec-IL-2) monoclonal antibody (moAb) 15.2 cross-reacts with a skin antigen located at the cell surface of human keratinocytes within the granular layer. This study extends the analysis of this IL-2-like material to its reactivity with eight antibodies raised against natural IL-2, rec-IL-2 or IL-2 peptides. Four among them were found to react with the granular epidermal layer as well as with a simian virus 40 (SV40) transformed human keratinocyte cell line. Each of these four antibodies gave similar labeling patterns, although with different intensities, and competitively inhibited each other. Analysis at the messenger RNA level in epidermal cells and SVK 14 also indicated that this material is very likely different from IL-2. From the knowledge, for some of these antibodies, of the amino-acid regions they recognize on the IL-2 molecule, it is inferred that the skin antigen shares with IL-2 at least two overlapping epitopes located in the 33-54 amino-acid region of IL-2, a region that has been shown to be involved in the binding of IL-2 to the IL-2-receptor (IL-2-R) 55 kD chain. Indeed, a purified recombinant soluble species of this IL-2-R is shown in this study to bind specifically to the IL-2-like skin material. As far as IL-2-R bearing cells are found in normal epidermis (Langerhans cells) and as important infiltrates of IL-2-R positive T lymphocytes are often encountered in cutaneous diseases, a potential role for this IL-2-like material in skin immunophysiopathology is suggested.
J Invest Dermatol 1989 Jul
PMID:Interleukin 2-like material in human epidermis: a ligand for the human interleukin 2-receptor 55 kD alpha chain. 247 41

Skin allografts were first used at the end of the last century by Girdner [Girdner JH. Skin grafting with graft taken from the dead subject. Med Rec (NY) 1881;20:119-20]; however, routine storage of human tissue developed only in the 1930s to 1940s [Webster JP. Refrigerated skin grafts. Ann Surg 1944;120:431-49] when reliable preservation methods became available. The first proper skin bank was the US Navy Skin Bank, set up in 1949 [McCauley RL. The skin Bank. In: Herndon DN, editor. Total burn care. 1st ed. Philadelphia: Saunders; 1996. p. 159-63]. Several skin banks were subsequently established in the United States and Europe, and in most cases they were organized as multitissue banks. Nowadays, it is estimated that 30 to 50 tissue banks are active in the United States, working according to the American Association of Tissue Banking (AATB) standards (AATB. Standards for tissue banking; 1984) and federal regulations (Real E S and regulations. Fed Regist. 1993).
Clin Dermatol
PMID:Skin bank organization. 1602 30