Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty-five calves were delivered by caesarean section near to term. During the operation amniotic fluid was collected for determination of the lecithin/sphingomyelin (L/S) ratio. Clinical examination of the calves and analysis of blood gas concentration (venous blood) were carried out within the first hour of life. Fifteen out of 35 calves under examination did not show clinical or blood gas disorders in the course of the first hour of life. In these calves, the L/S ratio, which represents a measure for the maturity of the surfactant system, averaged 2.6. The other 20 calves, however, developed a respiratory distress syndrome together with a progressive respiratory and metabolic acidosis within the first hour of life. The L/S ratio in the animals affected with respiratory distress syndrome reached an average value of 1.5 which was significantly below that of the calves not suffering from respiratory distress. Eleven of the 20 calves which developed respiratory distress syndrome died within the first 60 hours of life. The most striking findings in the post mortem examinations of these animals were intracranial haemorrhages and pulmonary lesions (hyaline membranes, interstitial and alveolar oedema). On the basis of the significantly lower L/S ratio and the post mortem findings, it is to be assumed that the respiratory distress syndrome in calves, equally with that in infants, is attributable to a surfactant deficiency.
Vet Rec 1984 Feb 11
PMID:Neonatal respiratory distress syndrome in the calf. 654 30

A young kitten was presented with regurgitation of food at weaning. Episodes of respiratory distress and cyanosis were also present. The cause of food regurgitation was a perioesophageal vascular ring caused by left descending aorta and a right ligamentum arteriosum. This type of vascular ring has not previously been described. There was also anomalous development of the right subclavian artery and a large ventricular septal defect. The respiratory distress and cyanosis was most probably caused by a combination of tracheal compression by the vascular ring and a polycythaemia associated with the ventricular septal defect. Surgical correction was not attempted.
Vet Rec 1984 Apr 07
PMID:Unusual vascular ring in a cat: left aortic arch with right ligamentum arteriosum. 671 87

An acute pneumonia developed in 28 calves which had been housed together from one to two weeks of age. The clinical signs included pyrexia, tachypnoea, respiratory distress and coughing. Some of the calves died. The pneumonia was characterised by an alveolitis with multinucleated syncytia, alveolar epithelial hyperplasia and bronchiolitis. Interstitial emphysema was also present. Fifteen of 19 calves examined serologically had rising neutralising antibody titres to respiratory syncytial virus; in nine calves the rise was fourfold or greater. Respiratory syncytial virus was not isolated from the calves. There was no evidence of parainfluenza type 3 virus involvement. The adult cows being sucked by the calves remained clinically normal throughout the incident. Six calves examined six weeks after the outbreak started had a chronic cuffing pneumonia characterised by lymphocytic bronchiolitis; some of the calves also had bronchiolitis obliterans. Mycoplasma dispar was found in two of them.
Vet Rec 1981 May 09
PMID:Acute fatal pneumonia in calves due to respiratory syncytial virus. 725 27

Eighteen Belgian white and blue double-muscled calves suffering from the acute respiratory distress syndrome were studied. Fifteen of the calves inhaled ipratropium bromide (0.6 mg) four times a day for three to four days whereas the other three control calves inhaled sterile 0.9 per cent saline. All the animals were injected with ceftiofur sodium (1 mg/kg/day) for five days, the first injection being given one hour after the first inhalation of ipratropium bromide or saline. Arterial oxygen tension, alveolar arterial oxygen difference, carbon dioxide tension and arterial pH, respiratory and heart rates, oscillatory resistance and phase angle, measured by the mono-frequency forced oscillation technique, were recorded both before and one hour and 168 hours after the first inhalation. The measurement of oscillatory resistance and phase angle made it possible to resolve the impedance of the respiratory system into its real and imaginary components. The oscillatory compliance (Cosc) was determined from the imaginary component (Im). By one hour after the first inhalation of ipratropium bromide the oscillatory resistance was already significantly reduced and Im and Cosc had significantly increased, but the other parameters showed no significant improvement. However, between one hour and 168 hours after the first inhalation all the parameters reached physiological values. The control calves did not show any change. It was concluded that the pulmonary dysfunction associated with the acute respiratory distress syndrome in these calves was at least partly due to a severe bronchoconstriction.(ABSTRACT TRUNCATED AT 250 WORDS)
Vet Rec 1994 Jan 29
PMID:Functional effects of a muscarinic receptor blockade during acute respiratory distress syndrome in double-muscled calves. 817 69

A study was conducted among children under 12 years of age admitted to a rural district hospital in western Kenya to evaluate the use of blood transfusions, identify risk factors for severe anemia, and determine when transfusion improves survival of severely anemic children. A total of 2433 children were admitted to the pediatric ward during the 12-month study period; 29% (684) had severe anemia (hemoglobin [Hb] 5.0 g/dl) and 20% (483) received blood transfusions. Among children admitted with Hb 5.0 g/dl, 19% (124/663) had a history of prior transfusion, compared with only 6% (94/1607) with Hb 5.0 g/dl. The fatality rate of all children with Hb 5.0 g/dl was 18%, compared with 8% among children with Hb 5.0 g/dl. Among all children who died during hospitalization, 48% had a Hb 5.0 g/dl at the time of admission. Children younger than 3 years old accounted for 92% of admissions with Hb 5.0 g/dl, 87% of all pediatric deaths, and 92% of all pediatric transfusions. Age under 3 years and malaria parasitemia were associated with severe anemia. 88% (424) of transfusions were given to children with Hb 5.0 g/dl. Only 25% (120) of transfused children received blood on the date of admission, while 34% (161) were transfused the day after admission, and 41% (199) were transfused 2 or more days after admission. Among children with Hb 5.0 g/dl, 40% (274/683) were not transfused. If transfusions had been given only within the first 2 days of admission to children with respiratory distress and Hb 5.0 g/dl, the frequency of transfusion would have been reduced by 55% without increasing mortality. Prevention and effective treatment of the causes of anemia (such as malaria), targeted to children under 3 years of age, are critically needed to limit pediatric anemia, blood transfusion, and anemia-associated mortality.
Wkly Epidemiol Rec 1994 Mar 11
PMID:Global programme on AIDS. A study on the effect of blood transfusion on survival among children in a Kenyan hospital. 819 7

An eight-year-old Highland pony which had previously shown normal laryngeal function, underwent general anaesthesia for surgical treatment of a mandibular sinus. During its recovery from the anaesthesia, the pony suffered great respiratory distress and stridor, due to total bilateral laryngeal paralysis and pulmonary oedema. The animal was immediately given a temporary tracheostomy. Some hours later, postoperative myositis developed; it resolved within two days and the pony's laryngeal function returned to normal during the following year.
Vet Rec 1993 Jan 09
PMID:Temporary bilateral laryngeal paralysis in a horse associated with general anaesthesia and post anaesthetic myositis. 844 33

Two aerosolised bronchodilators, one sympathomimetic and one parasympatholytic, were tested either alone or in combination for their ability to improve the pulmonary function of double-muscled calves suffering from acute respiratory distress syndrome. In control animals treated with 0.9 per cent saline the parameters of pulmonary function and signs of clinical distress did not change significantly within the hour following the first treatment. Among the other animals, both at one hour and seven days after the first treatment, the most clinical improvement was observed in the animals treated with both bronchodilators and the least in the animals treated with clenbuterol hydrochloride. One hour after the first treatment the respiratory system compliance of the animals treated with ipratropium bromide and the arterial oxygen tension of the animals treated with both bronchodilators were significantly enhanced. After seven days the resistive parameters, the rectal temperature and the respiratory rate were also significantly improved in the animals treated with ipratropium bromide or both bronchodilators whereas only the respiratory rate and rectal temperature were significantly reduced in the animals treated with clenbuterol hydrochloride.
Vet Rec 1995 Aug 19
PMID:Pulmonary function changes induced by three regimens of bronchodilating agents in calves with acute respiratory distress syndrome. 856 Jul 23

Enterotoxaemia in goats is mainly characterized by enterocolitis, and it has been suggested that the poor efficacy of commercial vaccines in preventing the disease is due to the local action of Clostridium perfringens toxin/s within the intestine, where circulating antibodies might not exert their action. Five goat kids were vaccinated with an incomplete Freund's adjuvant C perfringens type D epsilon toxoid vaccine on three occasions at three-week intervals, four similar kids were vaccinated with a commercial enterotoxaemia vaccine at the same times, and five other unvaccinated kids were used as controls. All the animals were challenged intraduodenally, one week after the last vaccination, with C perfringens type D filtered culture supernatant. At the time of challenge, the level of epsilon toxin antibodies in the serum of the Freund's adjuvant-vaccinated kids ranged between 2.45 and 230 iu/ml, while the kids that received the commercial vaccine had levels between 0.22 and 1.52 iu/ml. No clinical or postmortem changes were observed in the kids that received the Freund's adjuvant-vaccine. Three of the four kids that received the commercial vaccine developed mild, pasty diarrhoea, with a slight reddening of the colonic mucosa being observed postmortem. All the unvaccinated kids developed severe diarrhoea, respiratory distress and central nervous system signs, and were killed humanely between six and 24 hours after challenge. The postmortem changes consisted of pseudomembranous colitis, lung oedema and perivascular oedema of the brain. Moderate to high serum levels of anti-epsilon antibody appeared to protect the goats against both the systemic and the intestinal effects of C perfringens type D toxins.
Vet Rec 1998 Jun 27
PMID:Protection of goats against experimental enterotoxaemia by vaccination with Clostridium perfringens type D epsilon toxoid. 968 31

An 11-year-old, eight-months pregnant mare suddenly developed severe respiratory distress. Endoscopic examination identified intralaryngeal granulation tissue obstructing the airway. In order to avoid general anaesthesia and the problems associated with a permanent tracheostomy, the mass was resected electrosurgically while the mare was standing. Patency was restored to the airway and the mare foaled without complication.
Vet Rec 2000 Oct 07
PMID:Endoscopic electrosurgical excision of laryngeal granulation tissue in a standing pregnant mare. 1107 87

A two-and-a-half-year-old Friesian cow and a five-year-old Charolais cow developed severe respiratory distress and palpable swellings to the left of the larynx as a result of a dissecting aneurysm of the common carotid artery. Neither cow responded to medical treatment. The underlying pathogenesis of the condition was uncertain, but direct trauma to the carotid artery was a possible contributory factor. Aneurysms of the common carotid artery should be considered when swelling occurs in the region of the larynx or when respiratory distress is due to laryngeal compression.
Vet Rec 2001 Aug 04
PMID:Dissecting aneurysm of the carotid artery as a cause of respiratory distress in adult cattle. 1151 82


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