Gene/Protein Disease Symptom Drug Enzyme Compound
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 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A family of bull mastiff pups in which 16 animals developed certain neurological signs is described. It is probable that the disease is inherited in an autosomal recessive manner. Clinical and pathological examination of six animals revealed ataxia, behavioural abnormalities and a visual defect associated with symmetrical lesions in the cerebellar nuclei, lateral vestibular nucleus and inferior colliculus together with a communicating hydrocephalus. The cerebellar lesions consisted of vacuolation, gliosis and axonal degeneration. Evidence for both axonal and oligodendroglial abnormalities was present and these probably result from a genetically determined metabolic disturbance in the affected neurones.
Vet Rec 1983 Apr 09
PMID:Familial cerebellar ataxia with hydrocephalus in bull mastiffs. 685 76

One hundred anaesthetics were administered in a clinical trial to 95 equine patients, ranging in age from nine months to 19 years and in weight from 140 to 1270 kg, undergoing a variety of surgical procedures. Acepromazine maleate premedication (0.01 to 0.03 mg per kg intramuscularly) was given to seven animals, the remainder were not premedicated. Xylazine (1.1 mg per kg) was injected intravenously over a two minute period and after a pause of two minutes ketamine (2.2 mg per kg) was injected rapidly by the same route. For 30 procedures no other anaesthetic was given but in 59 cases anaesthesia was prolonged with halothane-oxygen while in 11 additional intravenous agents were administered. Recumbency followed one-and-a-half to two minutes after completion of the ketamine injection and limb movements occurring immediately after the animal lay down gradually subsided over the next 30 to 60 seconds. On 26 occasions when no other agent was given satisfactory operating conditions were produced for a mean (+/- sd) of 20 +/- 7 minutes and on four occasions when absence of complete muscle relaxation was observed surgery was still possible. When no other agent was given the onset of recovery was abrupt but recovery was always extremely quiet; the animals stood 33 +/- 10 minutes after induction of anaesthesia and showed a remarkable absence of ataxia. A similar recovery was seen in the 56 animals receiving halothane-oxygen and all stood 28 +/- 14 minutes after disconnection from the anaesthetic system. Heart block was observed during induction of anaesthesia bu otherwise cardiovascular and respiratory parameters were well maintained. It was concluded that the xylazine-ketamine combination had advantages over other current techniques of inducing anaesthesia in horses.
Vet Rec 1981 Jun 06
PMID:Clinical trial of xylazine with ketamine in equine anaesthesia. 702 71

The mean (+/- sd) liver copper level of 186 red deer (Cervus elaphus) (87 stags and 99 hinds) on the island of Rhum was 51.26 +/- 44.1 ppm dry matter. The level found in the south-east part of the island was significantly higher than elsewhere in hinds, but not in stags. Levels below 20 ppm dry matter, comparable to those found in cases of enzootic ataxia in deer parks, occurred in 18 stags and 20 hinds. Since enzootic ataxia has never been observed on Rhum, it is deduced that low copper status is not of itself the causal factor in that disease. No significant correlation was found between liver copper levels and stocking rate, age, carcase weight, antler weight, antler specific gravity, hind fertility, natural mortality or transferrin phenotype. It is concluded that above a low but perhaps critical level, the copper status of red deer merely reflects the dietary intake of that element.
Vet Rec 1981 Aug 22
PMID:Copper status of red deer on the island of Rhum. 732 61

Clinical and pathological findings from instances of ataxia in a group of wildebeeste (Connochaetes taurinus), two llamas (Llama glama) and one Arabian camel (Camelus dromedarius) are presented. Clinically, all the affected animals showed a non-febrile, progressive ataxia. Neuropathologically, Wallerian degeneration was diffuse in the spinal cord of the camel and llamas but was focal in the wildebeeste. Degeneration was present in the cervical dorsal roots in the wildebeeste and in the ventral nerve roots at all levels of the cord in the llamas. Peripheral nerve were affected in all the species. The possible roles of copper deficiency and plant poisons in the aetiology of the condition are discussed.
Vet Rec 1980 Jul 05
PMID:Ataxia and spinal cord degeneration in llama, wildebeeste and camel. 743 34

In a double blind study, eight horses were treated intravenously at seven-day intervals with detomidine at doses of 10, 20 and 40 micrograms/kg, or with romifidine at doses of 40, 80 and 120 micrograms/kg, or with a placebo solution. Their sedative and analgesic effects were evaluated by objective measurements and by a clinician at 15-minute intervals for three hours and the horses' instability in stocks, locomotor ataxia and heart rate were recorded simultaneously. The administration of both drugs at all doses resulted in sedation. The sedation achieved with romifidine was significantly shallower and shorter-lived than with detomidine at the recommended doses (P < 0.05). The results obtained with the highest dose of romifidine were in some cases significantly inferior and shorter-lived than those obtained with the medium dose (P < 0.05). Detomidine at the 10 micrograms/kg dose was similar in its effects to the two highest doses of romifidine. At all doses detomidine had analgesic properties against the effects of electrical pain stimulation at the withers, the coronary bands on the front and hind legs, and in the perianal region, which were dose-dependent in depth and duration, whereas romifidine was devoid of any analgesic effect. Instability and ataxia were more pronounced with detomidine than with romifidine but the effects were only slight to moderate and not regarded as a hindrance to procedures for which sedation is needed. Bradycardia was evident with both drugs at all doses; its severity and duration was related to the sedative properties of the drugs and was dose related. No other side effects were observed.
Vet Rec 1995 Apr 01
PMID:Sedative and analgesic effects of detomidine and romifidine in horses. 760 8

Aleutian disease was diagnosed as the cause of posterior ataxia and paresis in domestic ferrets. Six serologically positive animals (four clinically affected and two unaffected) were investigated in detail and seven other clinically affected ferrets were also identified. The diagnostic findings included hypergammaglobulinaemia, histological lesions in the central nervous system and parvovirus-like particles in mesenteric lymph nodes. A wider serological survey of 446 animals owned by members of a ferret club revealed an incidence of 8.5 per cent seropositive animals.
Vet Rec 1993 May 08
PMID:Aleutian disease in domestic ferrets: diagnostic findings and survey results. 823 11

In 1990 an outbreak of ataxia occurred in over 700 pigs in the north of England. Epidemiological studies demonstrated that the disorder was associated with the consumption of feed from a particular supplier and that one component (wheat screenings) was common to the batch of feed with which the ataxia was associated. An analysis of the feed demonstrated the presence of an organophosphorus pesticide, later identified as isofenphos, a pesticide not approved for use in the United Kingdom. The wheat screenings had been imported from France and the warehouse in which they had been stored was contaminated with isofenphos, which is approved for restricted use in France. Isofenphos is known to cause delayed neuropathy. The dose to which the pigs were theoretically exposed would be expected to have resulted in neuropathy (manifested as ataxia).
Vet Rec 1995 Jan 28
PMID:Delayed neuropathy in pigs induced by isofenphos. 774 Jul 24

An outbreak of equine herpesvirus-1 (EHV-1) occurred on a large stud farm with 133 mares, 54 foals and four stallions, and at least 85 mares, 22 foals and three stallions were infected. Clinical disease was observed in 16 mares, two stallions and 13 foals and the predominant clinical signs were scrotal oedema, ataxia and loss of libido in the stallions, ataxia and recumbency in the mares and uveitis and nasal discharge in the foals, although pneumonia and colic with intussusception were also recorded at autopsy. Neurological disease was more common in the mares nursing foals (12 of 38 infected) than in barren mares (one of 46 infected). Three mares died during the outbreak and no mares that had been recumbent bred again. Control procedures were based on virological and serological testing and stringent management practices to limit the spread of infection between groups of mares and foals and away from the stud farm. There were marked antibody responses in the adult horses, but they were generally poor in the foals; three of the nine viraemic foals did not develop significant increases in the levels of circulating antibody. Recommendations are made for the management of future outbreaks.
Vet Rec 1995 Jan 07
PMID:Clinical, serological and virological characteristics of an outbreak of paresis and neonatal foal disease due to equine herpesvirus-1 on a stud farm. 790 Feb 64

A haemangiosarcoma in a horse resulted in ataxia affecting all four legs, a low head carriage and a reluctance to flex the neck. Ancillary diagnostic procedures included the analysis of cerebrospinal fluid, standing lateral cervical radiographs and a myelogram. Post mortem a tumour was found which involved the body of the second cervical vertebra and the associated hypaxial muscles, with secondary intravertebral extradural infiltration and focal compressive myelopathy. A histological examination showed that the tumour was a haemangiosarcoma.
Vet Rec 1994 Aug 20
PMID:Ataxia due to a vertebral haemangiosarcoma in a horse. 799 76

Three horses with an apparent neurological disorder resulting from nettle rash showed signs of ataxia, distress and muscle weakness, and two of them had urticaria. In each case the condition resolved within four hours, with no long term problems or recurrence.
Vet Rec 1994 Jan 01
PMID:An unusual manifestation of nettle rash in three horses. 812 60


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