Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The mouse epididymal duct can be histologically divided into five segments (I-V), and the principal cells in segment II appear to secrete periodic acid-Schiff (PAS)-positive material into the lumen. In this study, male dd-mice received one, two, or four 800-R doses of radiation beginning at age 50 days. Mice receiving multiple doses were irradiated at 1-week intervals. After irradiation, marked depletion of spermatozoa, or aspermia, occurred in the epididymal duct for 2 to 16 weeks after a latency period of 3 to 4 weeks according to the times of irradiations. During oligospermia or aspermia, PAS-positive inclusions appeared in the principal cells in segment IV. The inclusions occupied a supranuclear position and appeared as round granules and globules measuring 2-15 micron in diameter, and increased in number, size, and staining intensity with time. They disappeared after reappearance of spermatozoa. The findings suggest that PAS-positive material may bind to spermatozoa and, if not bound, is reabsorbed by the principal cells in segment IV and deposited as intracellular inclusions, and the principal cells in segment IV are capable of digesting the accumulated PAS-positive material.
Anat Rec 1983 Sep
PMID:Response of epididymal duct to the temporary depletion of spermatozoa induced by testicular irradiation in mice. 663 30

In an attempt to induce permanent aspermia the caudae epididymes of 17 bulls were subjected to ligation or injection with ethanolamine or chlorhexidine in dimethyl sulphoxide. Nylon and polyglycolic acid ligatures had little or no effect on the sperm counts although these materials were used in only three bulls. Steel ligation induced aspermia of several weeks' duration in four of six bulls. Although the effect in at least three of these animals might have been permanent, the trial was discontinued because the other two bulls, treated identically, showed little response. Ethanolamine injected into the epididymis also had little or no effect on the ejaculate. By contrast the chlorhexidine preparation produced an almost immediate aspermia sustained until the bulls were slaughtered a year later.
Vet Rec 1980 Sep 20
PMID:Ligation and sclerosis of the epididymis in the bull. 721 Apr 23