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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We examined the effect of 20 micrograms recombinant gamma-interferon (rec-gamma-IFN) upon corticotropin (ACTH) and cortisol secretion in 10 healthy male controls. We observed that rec-gamma-IFN enhances cortisol secretion with maxima around 3 hours after injection of the test dose. This effect was suppressible by a single dose of 1.5 mg dexamethasone and was not associated with increased ACTH secretion. Rec-gamma-IFN also failed to enhance ACTH secretion from a pituitary cell culture. From these data we conclude that rec-gamma-IFN acts on lymphoid cells which in turn release a yet unidentified substance that directly activates the adrenocortex in a feedback controlled manner.
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PMID:Acute adrenocortical stimulation by recombinant gamma interferon in human controls. 282 52

Two groups of puppies, one passively immunised by the administration of hyperimmune serum and the other with natural maternally derived antibody, were inoculated orally with virulent canine parvovirus of faecal origin. Serum antibody titres declined more rapidly in both groups after challenge than before. The dogs became clinically affected but the onset of clinical signs, seroconversion and faecal excretion of virus was delayed when compared to controls. It is postulated that this rapid decline of antibody was due to its sequestration by virus after the initial phase of viral replication in the lymphoid tissues. These findings have important implications. The incubation period of the disease is prolonged, making it more difficult to estimate accurately the time of infection in clinically affected animals. Furthermore, the more rapid decline of maternally derived antibody, which could occur in endemically infected premises, may complicate immunisation programmes based on the isolation and segregation of puppies in anticipation of a predicted decline in maternally derived antibody before vaccination.
Vet Rec 1988 Jun 11
PMID:Canine parvovirus: interaction between passive immunity and virulent challenge. 284 25

A goat herd severely affected by arthritis was studied. The most representative clinical signs consisted of articular swelling, mainly of the carpal joints, and the subsequent locomotor disorders. Some goats also showed signs of central nervous system involvement. Examinations of joint fluid revealed an increased number of mononuclear blood cells, mostly lymphocytes. Gross and microscopic articular lesions were of inflammatory and degenerative types. Periarticular connective tissue, synovial bursae, tendons and tendon sheaths were predominantly affected. Inflammatory lesions were those of a chronic hyperplastic tenosynovitis with fibrosis of the connective tissue components. Degenerative changes consisted mainly of necrosis and mineralisation of articular-related structures. Histological lesions in the central nervous system were those of a nonpurulent encephalitis initially located in periventricular areas, but in one case extensive encephalomalacia was also seen. Of the 80 animals sampled 82.5 per cent showed seropositive reactions against an ovine progressive pneumonia virus antigen. None was seropositive to brucella and titres to chlamydia were low. Attempts to isolate chlamydia and mycoplasma from affected joints and several organs failed. Different bacteria were recovered from a few samples but did not seem significant. Syncytium-forming viral particles were isolated from several organs, mainly the lungs, synovial membranes and lymphoid tissue of almost all the slaughtered animals. These particles were identified as lentiviruses by electron microscopy. The clinical signs, lesions serological results and microbiological findings, led to a diagnosis of caprine arthritis-encephalitis. This syndrome has not been recognised in Spain previously.
Vet Rec 1987 Jan 31
PMID:Caprine arthritis-encephalitis in the Basque country, Spain. 303 62

Three goats, experimentally infected with rinderpest virus were examined for the development and distribution of precipitating antigens in various tissues and secretions using the agar gel immunodiffusion test. Virus antigens were detected in ocular secretions and lymph node biopsies from the second to the fourth and fifth days of pyrexia, respectively, but were not detected in nasal secretions. Precipitating antigens were demonstrated in various lymphoid organs, the lung and abomasum of a goat killed on the fourth day of pyrexia. These findings are discussed in relation to the epidemiology of rinderpest in goats in Africa.
Vet Rec 1988 Aug 20
PMID:Development and distribution of rinderpest virus antigen in experimentally infected goats. 314 Apr 70

A population of adult CBA/J mouse bone marrow (BM) cells enriched by in vitro migration to supernatant prepared from neonatal thymus was labeled with a DNA-binding fluorochrome, Hoechst dye No. 33342 (H33342). Labeled cells were injected into irradiated recipients in order to compare the in vivo localization of the migration-enriched BM (MEBM) cells to the localization of injected nonenriched BM (NEBM) cell controls. A characteristic difference in the distribution of localized cells was observed in the spleen but not in other lymphoid organs. At 2 hr after injection the MEBM cells were located in the marginal zones surrounding the periarterial lymphoid sheaths (PALS) of the splenic white pulp. At 6 hr after injection the MEBM cells were seen distributed between marginal zones and the PALS and by 16 hr they had localized almost exclusively in the white pulp. In contrast, the NEBM cells were located in the marginal zones or red pulp for the duration of the experiment. These observations show that the MEBM cells home selectively to T-cell areas of the spleen. Direct immunofluorescent monoclonal antibody staining of H33342-labeled cells obtained from the recipient spleens at 16 hr demonstrated that the MEBM cells were negative for Thy-1 antigen, indicating that acquisition of Thy-1 was not prerequisite to the observed homing. The results are compared to known localization patterns of mature lymphocytes.
Anat Rec 1988 Jul
PMID:In vivo homing of thymus-enriched bone marrow cells. 318 66

Here we describe a nodule of lymphoid tissue which was consistently located in the proximal colon of mice approximately 25% of the distance from the cecum to the rectum. Immunohistochemical characterization of this nodule demonstrated that the majority of lymphocytes were relatively immature 14.8+ (B220+), IgM+, Ia+ (specificity 20) B cells some of which were also Ly-1+. These nodules also possessed an occasional T cell (Thy-1+, Ly-1+, Lyt-2+) aggregate at the periphery. Rare, small areas did not stain for either T or B cell markers. These lymphoid nodules were associated with epithelial cells which stained positively with the ER-TR4 monoclonal antibody (which also recognizes thymic cortical epithelial cells) and also with ER-TR6, which has been reported to recognize thymic macrophages or dendritic cells. The overlying colonic epithelium stained intensely with the ER-TR4 monoclonal antibody. Proximal colonic lymphoid tissue was extremely sensitive to steroid treatment, losing approximately 80% of its mass within 24 hours in response to a single intraperitoneal injection of 2 mg hydrocortisone acetate. This response was similar to that of the thymus and to that reported for the bursa of Fabricius, but unlike that of other gastrointestinal lymphoid aggregates. These results indicated that proximal colonic lymphoid tissue contains a high frequency of relatively immature B cells and may be a primary site of their generation, possibly including some of the Ly-1+ phenotype. These observations correlate with new evidence suggesting that the allantois participates in the formation of the distal midgut, including its lymphoid components.
Anat Rec 1988 Mar
PMID:Characterization of proximal colonic lymphoid tissue in the mouse. 336 57

Esterase activity studies on the areas of lymphoid infiltration in the bursa of Fabricius (diffusely infiltrated area) and the dorsal wall of the cloaca showed that the epithelial cells exhibit varying degrees of diffuse esterase activity; it was possible to demonstrate the presence of spot-like esterase positivity in star-shaped cells in the epithelium itself. These cells can be found at various levels from the proximal to the distal region and have also been observed in the connective tissue of the tunica propria; as a result, the hypothesis has been advanced that they are connective tissue.
Anat Rec 1988 May
PMID:Distribution of esterase activity at the level of the epithelium of the diffusely infiltrated area (DIA) and of the cloaca in the Gallus domesticus: an ultrastructural study. 338 31

The term myeloproliferative disease may be applied to all the non-lymphoid dysplastic and neoplastic conditions arising from the haematopoietic stem cell or its progeny. Thus the chronic and acute myeloid leukaemias, thrombocythaemia, megakaryocytic myelosis, myelofibrosis, the myelodysplastic syndromes and some cases of aplastic anaemia may be viewed as variants of a single disease process. This view is useful in explaining the common occurrence of mixed forms of disease or interconversions between the myeloproliferative diseases. This variability is a consequence of the development of all the haematopoietic lineages from a single class of haematopoietic stem cell by progressive differentiation. The aetiology of the myeloproliferative diseases in the domestic animals is uncertain but feline leukaemia virus infection has been implicated in the cat. These conditions may be classified as aplastic anaemia, as preleukaemic dysplastic conditions with variable cytopenias and morphological abnormalities of blood cells, as smouldering leukaemias, or as leukaemias with a frankly leukaemic blood or bone marrow.
Vet Rec 1987 Nov 07
PMID:Myeloproliferative disease in the dog and cat: definition, aetiology and classification. 342 14

Rabbits were intravenously primed and boosted with trinitrophenyl-keyhole limpet hemocyanin (TNP-KLH) and human serum albumin (HSA); both antigens were injected simultaneously. The localization of anti-TNP-antibody-forming cells (AFCs) and anti-HSA-AFCs was determined in various lymphoid organs of the rabbit. In all lymphoid organs of primed rabbits anti-TNP-AFCs outnumbered anti-HSA-AFCs, with the exception of the thymus, in which neither of them was encountered. In the spleen the antibody-forming cells were mainly situated in the periphery of the periarteriolar lymphocyte sheaths (PALS) and in the coaxial sheaths of lymphoid tissue surrounding the terminal arterioles. In the lymphoepithelial organs AFCs were almost exclusively situated in the interfollicular areas, and in the lymph nodes largely in the medulla. An intravenous booster injection led to a secondary immune response (i.e., increase of AFCs) in the spleen. No visible change in the number of specific AFCs was observed in the lymphoepithelial organs. However, in the mesenteric and popliteal lymph node the number of anti-TNP-AFCs had increased tremendously.
Anat Rec 1987 Jan
PMID:Development of specific antibody-forming cells in various lymphoid organs of rabbit after intravenous antigen administration. 345 65

M cells are specialized epithelial cells over lymphoid follicles in Peyer's patches which take up viruses, bacteria, and antigenic macromolecules from the intestinal lumen. Unlike ordinary enterocytes which sequester pinocytosed material in lysosomes, M cells transport such material across the epithelium to antigen-processing areas in lymphoid follicle domes, suggesting a difference in lysosomal activity or a different route for movement of endocytic vesicles. Ileal Peyer's patches in rats were examined by electron microscopy to identify lysosomes by acid phosphatase activity. Acid phosphatase was found in dense bodies in enterocytes but not in M cells. Stereological analysis showed the volume fraction occupied by dense bodies in M cells to be 16 times less than in enterocytes (P less than .0005), even though the volume fractions of cytoplasm occupied by mitochondria in M cells and enterocytes were not significantly different. The small volume fraction of dense bodies and the absence of acid phosphatase activity in M cells thus correlate with absence of lysosomal degradation of luminal microorganisms during transport into lymphoid follicles by M cells and may provide not only a complete array of microbial antigens for initiation of immune responses, but also a route through the mucosal barrier for microorganisms which can evade local containment mechanisms.
Anat Rec 1986 Dec
PMID:Morphometric and cytochemical analysis of lysosomes in rat Peyer's patch follicle epithelium: their reduction in volume fraction and acid phosphatase content in M cells compared to adjacent enterocytes. 379 99


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