Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Over the period from March 1990 to December 1998, veterinary surgeons in general practice were invited to submit tissues suspected of being neoplastic which had been removed from flat-coated retrievers. When possible, pedigree details were obtained from the owners. In addition, data were collected from flat-coated retrievers known to have suffered from a neoplastic condition and for which a histopathological report was available. A total of 1023 submissions was obtained from 782 dogs. These included 165 non-neoplastic lesions (16 per cent), 447 benign samples (44 per cent) and 411 malignant samples (40 per cent). Soft tissue sarcomas accounted for 55 per cent of the malignant samples (26 per cent of all tumour samples and 22 per cent of all submissions) with 63 per cent of them being diagnosed as undifferentiated. Carcinomas accounted for 20 per cent of malignant samples (8 per cent of all submissions). Of the benign tumours, cutaneous histiocytoma was the most common diagnosis (48 per cent of benign tumours, 25 per cent of all tumours and 21 per cent of all submissions).
Vet Rec 2000 Sep 09
PMID:Histopathological survey of neoplasms in flat-coated retrievers, 1990 to 1998. 1103 28

Canine cutaneous histiocytoma is a common skin tumour of Langerhans cell origin. Langerhans cells are members of the dendritic cell family of antigen-presenting cells and are located in the epidermis. They are unique among the dendritic cell lineage in that they express high levels of the adhesion molecule E-cadherin. The expression of E-cadherin by the neoplastic Langerhans cells in 37 dogs with cutaneous histiocytoma was studied by flow cytometry and immunohistochemistry. In all the cases, these cells expressed E-cadherin, whereas the infiltrating lymphocytes did not.
Vet Rec 2008 Apr 19
PMID:E-cadherin expression in canine cutaneous histiocytomas. 1862 5

Cutaneous neoplasia occurs commonly in dogs and owners in consultation with their veterinarian must decide when to perform surgery to obtain a histopathological diagnosis. The objective of this study was to identify breed predispositions for canine cutaneous neoplasms and determine factors associated with malignancy. This retrospective case-series evaluated histopathology reports from two veterinary pathology laboratories in South Africa during a six-month study period. Breed predispositions were analysed using log-linear models and risk factors for malignancy were evaluated using binary logistic regression. Data were available for 2553 cutaneous neoplasms from 2271 dogs. The most frequent neoplasms were mast cell tumours (21.1per cent), histiocytoma (9.4per cent), haemangiosarcoma (8.3per cent), melanocytoma (5.8per cent) and lipoma (5.1per cent). Boxers (relative proportion (RP)=38.9; 95% CI 2.3 to 646), pugs (7.6; 1.4 to 41.0), Staffordshire bull terriers (7.0; 1.9 to 26.3), boerboels (3.8; 1.3 to 10.7), Labrador retrievers (2.7; 1.0 to 7.0) and mixed breed dogs (2.2; 1.1 to 4.4) had a higher frequency of mast cell tumours. Jack Russell terriers (OR=2.5; 95% CI 1.8 to 3.5), Rottweilers (2.3; 1.3 to 3.9), pit bull terriers (2.2; 1.1 to 4.3) and Staffordshire bull terriers (1.6; 1.0 to 2.6) were more likely to have malignant neoplasms. Dog signalment might facilitate prognosis determination for cutaneous canine neoplasia before receiving a histopathological diagnosis.
Vet Rec 2020 Feb 22
PMID:Breed and anatomical predisposition for canine cutaneous neoplasia in South Africa during 2013. 3143 20