Gene/Protein Disease Symptom Drug Enzyme Compound
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 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to assess the usefulness of haptoglobin as a measure of the acute phase response in cattle, the concentration of serum haptoglobin was estimated in the non-infectious conditions of milk fever and ketosis, and in the infectious conditions of severe mastitis, acute severe metritis, retained placenta and chronic endometritis. Mean haptoglobin concentrations were normal in cattle with non-infectious conditions and chronic endometritis but significantly increased in cattle with infectious conditions.
Vet Rec 1991 Feb 16
PMID:Bovine haptoglobin response in clinically defined field conditions. 190 6

An automated method for the estimation of the acute phase protein haptoglobin was developed and used to compare the blood haptoglobin concentrations of 42 sheep examined post mortem with other haematological findings in infectious and non-infectious conditions. Haptoglobin was also assayed in 863 sheep from nine apparently normal flocks; of these sheep seven per cent had significantly raised haptoglobin levels. The studies showed that haptoglobin was useful as a marker for the presence of bacterial infection in sheep, and was more sensitive, specific and efficient and less likely to give false positive and negative results than a haematological examination.
Vet Rec 1994 Jan 08
PMID:Haptoglobin as an indicator of infection in sheep. 813 4

In a previous study in dogs with chronic liver disease it was found that a combination of clinical features and laboratory findings was useful in differentiating liver diseases but could not be used to evaluate a dog's prognosis. When an electrophoretic analysis of the serum proteins was included, marked decreases in the concentrations of albumin and the alpha-globulins alpha-1-antitrypsin and haptoglobin were observed in terminal liver cirrhosis, indicating impaired liver function. However, low albumin concentrations, together with normal or increased concentrations of alpha-1-antitrypsin and haptoglobin, were observed in dogs which, although severely depressed when examined, often recovered and survived for a year or more.
Vet Rec
PMID:Serum protein electrophoresis as a prognostic marker of chronic liver disease in dogs. 896 72

Feline infectious peritonitis (FIP) is notoriously difficult to differentiate from the many other diseases with similar clinical signs and at present the only conclusive diagnostic test is the histopathological examination of a biopsy. The potential value of raised levels of the acute phase reactants, alpha 1-acid glycoprotein (AGP) and haptoglobin in the diagnosis of the disease was investigated. The concentrations of the two proteins were determined in serum samples from healthy cats and gave reference ranges of 0.1 to 0.48 g/litre and 0.04 to 3.84 g/litre, respectively. Levels of AGP greater than 1.5 g/litre in serum, plasma or effusion samples were found to be of value in distinguishing field cases of FIP from cats with similar clinical signs and differentiated these two groups of cats more effectively than the albumin:globulin ratio. The concentration of haptoglobin was higher in cats with FIP than in the group of healthy cats, but this protein was not of value in the diagnosis of FIP. Serum samples from feline immunodeficiency virus-infected cats were also analysed for these proteins and their concentrations were significantly elevated, illustrating that raised levels of AGP and haptoglobin are not pathognomonic for FIP.
Vet Rec 1997 Sep 20
PMID:Value of alpha 1-acid glycoprotein in the diagnosis of feline infectious peritonitis. 933 Apr 74

The serum concentration of haptoglobin was measured in 51 cows with toxic puerperal metritis which were being treated with one of three different antimicrobial regimens. The mean concentration of haptoglobin was 19.0 mg/dl on the day that the treatments began and declined steadily during the five day treatment period to a mean concentration of 7.35 mg/dl. There was no correlation between the serum haptoglobin concentrations and the rectal temperatures of the cows during the five days.
Vet Rec 1998 Jan 24
PMID:Serum haptoglobin concentrations in Holstein dairy cattle with toxic puerperal metritis. 949 28

Acute phase proteins such as serum amyloid A, haptoglobin, and alpha 1-acid glycoprotein have been identified as markers of inflammation in cattle because they are produced by the liver in response to pro-inflammatory cytokines. This study was designed to assess whether they could be used to discriminate between acute and chronic inflammation. Their concentrations were measured in serum samples from 81 cattle in which inflammation was classified by thorough clinical examination, supported by postmortem findings, as being acute in severity in 31 and chronic in 50. The classical haematological markers of inflammation were also determined in blood from the animals. Serum amyloid A had a maximum (100 per cent) clinical sensitivity in discriminating between the acute and chronic cases, and haptoglobin had the highest clinical specificity of 76 per cent; counts of neutrophils and band neutrophils had sensitivities of 71 per cent and 42 per cent and specificities of 30 per cent and 72 per cent, respectively. It was concluded that serum amyloid A and haptoglobin may be used to discriminate between acute and chronic inflammatory conditions.
Vet Rec 1999 Apr 17
PMID:Acute phase proteins in cattle: discrimination between acute and chronic inflammation. 1034 75

The rate of uterine involution postpartum was monitored in 13 suckling mule ewes by using radio-opaque markers and radiography, and each ewe was also monitored for intrauterine bacterial contamination during the first week, using a sterile guarded swab. Peripheral plasma or serum concentrations of haptoglobin, seromucoid, ceruloplasmin and 15-keto-13,14-dihydro-prostaglandin F2 alpha (PGFM) were measured up to six weeks postpartum. The maximum reduction in the length of the uterine body and in the diameters of the horns occurred by 28 days postpartum, except in one ewe in which the size of the uterus continued to decrease for 42 days. Four ewes were positive for intrauterine bacterial contamination; Escherichia coli, clostridial species, Staphylococcus aureus, Streptococcus uberis and Enterococcus species were isolated in pure or mixed culture. The presence of intrauterine bacteria did not affect the time for the completion of uterine involution. No bacteria were isolated from the ewe in which involution was delayed, but it had a different acute phase protein response and was therefore excluded from further analyses. In the remaining 12 ewes the mean postpartum haptoglobin response increased, with peak concentrations occurring on day 1, and decreased slowly as uterine involution progressed, but the four contaminated ewes had a significantly greater response. There was no difference between the prepartum and postpartum concentrations of seromucoid in the eight sterile ewes, but significant increases were observed in the contaminated group; the concentrations of ceruloplasmin did not vary in either group. The concentrations of PGFM were higher during the early postpartum period in the ewes with contaminated uteri.
Vet Rec 1999 May 01
PMID:Acute phase protein response of ewes and the release of PGFM in relation to uterine involution and the presence of intrauterine bacteria. 1203 44

Fourteen calves were used to investigate the changes from birth to 83 days of age in the concentrations of serum albumin, alkaline phosphatase, beta-hydroxybutyrate, plasma cortisol, serum creatine kinase, creatinine, iron, plasma fibrinogen, serum gamma-glutamyl transferase, plasma glucose, haptoglobin, serum non-esterified fatty acids, total protein, transferrin, triglycerides, urea and gamma globulin; the haematological variables measured were: basophils, eosinophils, haematocrit, haemoglobin, lymphocytes, mean cell haemoglobin, mean cell haemoglobin concentration, mean cell volume, monocytes, band neutrophils, neutrophils, platelets, red blood cells and white blood cells. The changes are presented as a series of graphs and the values are discussed in relation to the published reference ranges for adult cattle. Two populations of calves were identified which gave rise to a bimodal distribution for some of the variables. Differences in haematocrit, haemoglobin and red blood cell counts were apparent at birth, with raised values for these measurements being associated with an increased white blood cell and neutrophil count between three and 27 days of age.
Vet Rec 2000 Nov 18
PMID:Changes in the blood biochemical and haematological profile of neonatal calves with age. 1111 Apr 79

Changes in the patterns of glycosylation of canine haptoglobin have recently been demonstrated by isoelectric focusing and immunoblotting. Fucosylated fractions of haptoglobin were identified by selective binding of a fucose-specific lectin. In this study, similar changes were found in the serum of 86 of 137 dogs with various inflammatory, autoimmune and neoplastic diseases. Major changes, including fucosylation, were observed in 40 of the dogs and were most frequent in association with autoimmune haemolytic anaemia. All 40 cases had markedly increased concentrations of haptoglobin and decreased concentrations of haemoglobin. Minor changes were found in the other 46 dogs, whereas no changes in glycosylation were detected in the serum of 40 healthy dogs.
Vet Rec 2001 Jan 06
PMID:Abnormal microheterogeneity of haptoglobin in serum from dogs with various diseases. 1120 Mar 99

The serum concentrations of haptoglobin, serum amyloid A and alpha1 acid glycoprotein were determined in serum collected from healthy dairy cows and cows with clinical mastitis, graded as mild (clots in milk) or moderate (clots in milk and visible signs of inflammation in the mammary gland/s) to assess their relative diagnostic value in detecting the disease. The concentrations of haptoglobin and serum amyloid A were also measured in milk collected from infected and uninfected quarters. The concentrations of haptoglobin and serum amyloid A were higher in the serum and milk from the cows with mild or moderate mastitis. The diagnostic value of haptoglobin in differentiating between healthy animals and those with mastitis gave sensitivities and specificities of 82 per cent and 94 per cent respectively with serum and 86 per cent and 100 per cent with milk. The diagnostic value of serum amyloid A in differentiating between healthy animals and those with mastitis gave sensitivities and specificities of 83 per cent and 90 per cent with serum and 93 per cent and 100 per cent with milk. The diagnostic value of serum alpha1 acid glycoprotein in differentiating between healthy animals and those with mastitis gave sensitivities and specificities of 62 per cent and 91 per cent.
Vet Rec 2001 Jan 13
PMID:Acute phase proteins in serum and milk from dairy cows with clinical mastitis. 1120 51


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