Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The persistence of virus in the bone marrow of cats which had ostensibly recovered from feline leukaemia virus (FeLV) infection was investigated. Nineteen cats were exposed to FeLV by natural, contact infection and 36 weeks later three were found to be persistently viraemic while the remainder were non-viraemic and had virus neutralising serum antibodies. Virus was isolated in bone marrow cultures established from nine of the 16 non-viraemic cats which were considered, therefore, to have latent infections. Cats infected soon after exposure to FeLV carrier cats were more likely to become persistently viraemic or develop a latent infection than those infected later, which tended to recover. There was no difference in serum antibody levels between the latently infected and recovered cats. Whether cats with latent infections spread virus or develop FeLV-negative haemopoietic tumours was considered. Six kittens housed together for eight months with a cat with a latent infection showed no signs of having been exposed to FeLV. Virus was not isolated from bone marrow cultures of two cats with FeLV-free lymphosarcoma or myelomonocytic leukaemia.
Vet Rec 1983 Apr 09
PMID:Recovery of feline leukaemia virus from non-viraemic cats. 630 86

Since 1959, the Pig Health Control Association (PHCA) has run a national health-control scheme for pig herds believed to be free from enzootic pneumonia. During this time, many herds developed this disease without a simple explanation. From 1968, 55 such unexplained breakdowns have been studied in detail. The first signs in 50 breakdowns were either coughing in growing pigs (52 per cent of outbreaks), illness in adult stock (34 per cent of outbreaks) or pneumonia in routinely slaughtered pigs (14 per cent of outbreaks). In some outbreaks, enzootic pneumonia appeared to grow out of a pre-existing respiratory infection, which was not identified as enzootic pneumonia, in suckling pigs, suggesting that either Mycoplasma hyopneumoniae was already present in a latent state, or it more readily seeded damaged respiratory tracts from outside. In three outbreaks of this type, where pathological material was collected during the transition period, no laboratory evidence was obtained for the presence of M hyopneumoniae in the primary respiratory disease. Analysis of breakdowns in two national testing stations indicated that clinical/pathological signs might not develop until three to five months after the introduction of an infected group of weaners. It is possible, therefore, that a pig herd might not show obvious signs of the disease until up to six months or more after initial infection. There was little evidence to indicate that unexplained breakdowns arose from long term latent infection in other herds from which stock had been imported. There was considerable evidence, however, to suggest that breakdowns arose from extraneous sources.(ABSTRACT TRUNCATED AT 250 WORDS)
Vet Rec 1984 Sep 29
PMID:Apparent reinfection of enzootic-pneumonia-free pig herds: early signs and incubation period. 649 92

Nine cows which were naturally and persistently infected with Neospora caninum were housed and observed intensively throughout pregnancy. No recrudescence of a latent infection was detected by PCR tests on maternal blood but fetal infection, implying a recrudescence of maternal parasitosis, was associated with a marked increase in maternal antibody. The increase occurred in the second half of pregnancy in five cows which infected their calves, and before mid-pregnancy in one cow which aborted. There was no change in the avidity of the antibody, which remained high and characteristic of long-term infection. In three infected cows that gave birth to uninfected calves there was no marked increase in maternal antibody. Antigen-specific interferon gamma responses of peripheral blood mononuclear cells were observed in all the infected cattle but they did not vary significantly either during pregnancy, or whether the cows did or did not infect their calves, although the responses were consistently higher in the latter. There was no change in the plasma concentrations of cortisol or acute phase proteins associated with the recrudescence of the parasite. Three uninfected cows housed with the infected cows remained uninfected throughout the experiment. No immunosuppressive event was detected which might have provoked parasite recrudescence but the acute antibody rise associated with transplacental infection provides a valuable, non-invasive marker for further studies to investigate the cause and consequences of parasite recrudescence in N caninum infection in cattle.
Vet Rec 2001 Oct 13
PMID:Neospora caninum in persistently infected, pregnant cows: spontaneous transplacental infection is associated with an acute increase in maternal antibody. 1168 46