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A double blind field trial was carried out with a live attenuated bovine respiratory syncytial virus vaccine. The trial involved 530 calves, two to 10 months old, on 27 dairy farms, where respiratory problems due to bovine respiratory syncytial virus infections had been observed during the preceding year. In 17 herds either all calves were vaccinated (nine groups) or all calves received a placebo (eight groups). In 10 herds half the number of calves were vaccinated and the other half kept as non-vaccinated controls. Calves were vaccinated intramuscularly twice with an interval of four to five weeks. These groups were under regular clinical observation and animals were tested periodically for antibodies to bovine respiratory syncytial virus and parainfluenza type 3 virus. Serological examination indicated that no bovine respiratory syncytial virus infection had occurred prior to the first vaccination in August. Vaccination did not cause adverse reactions. Low concentrations of neutralising and complement fixing antibodies were induced by vaccination and a sharp increase of antibody titres was observed after natural infection of vaccinated animals. Infections with bovine respiratory syncytial virus occurred in six out of eight non-vaccinated groups, in nine out of 10 partly vaccinated groups and in only two out of nine completely vaccinated groups. Virus infection in completely vaccinated groups was significantly reduced compared with partly vaccinated and non-vaccinated groups. The incidence of bovine respiratory syncytial virus lower respiratory disease was significantly reduced in completely vaccinated groups compared to non-vaccinated groups. Generally only mild signs of upper respiratory disease were present in completely vaccinated groups after bovine respiratory syncytial virus infection.(ABSTRACT TRUNCATED AT 250 WORDS)
Vet Rec 1984 Nov 10
PMID:Prevention of bovine respiratory syncytial virus infection and clinical disease by vaccination. 609 14

Of 1388 horses and ponies examined at two abattoirs in the north of England from November 1979 to September 1981, 123 (8.7 per cent) showed evidence of hydatid infection. Prevalence of infection was closely related to age, rising from nil in animals up to two years old to over 20 per cent of those over eight years. Full-mouthed horses and ponies had similar prevalence rates (14.9 and 14.5 per cent, respectively), but horses had nearly twice as many viable infections as ponies. The prevalence of infection varied with the region of origin of full-mouthed horses and ponies, with 18 per cent of those from mid and north west England infected, compared with approximately 12 per cent of horses and ponies from mid and south Wales, Yorkshire and Scotland. The highest rates of transmission of equine hydatidosis are believed to occur in south and east England. Infections were mainly hepatic, with only 11 per cent lung involvement. Sixty-six per cent of the infections were viable, 71 per cent of which had between one and 10 cysts. Multiocular cysts occurred in 26 per cent of infections.
Vet Rec 1982 May 29
PMID:Observations on the epidemiology of equine hydatidosis in Britain. 710 13

In spring 2011, high mortality in association with skin lesions, systemic haemorrhages and necrosis occurred in a group of green striped tree dragons (Japalura splendida) which were imported from southwestern China via Florida to Germany. Infections with various endoparasites were diagnosed in coprological examinations. Different antiparasitic and antibiotic treatments over a period of three months did not reduce the mortality rate. The remaining animals were therefore euthanased and submitted for additional testing. Predominant findings in pathological examination were granulomatous and necrotising inflammation of the skin, vacuolar tubulonephrosis of the distal renal tubules, hyperaemia and liver necrosis. Eosinophilic intranuclear and basophilic intracytoplasmic inclusion bodies were detected in the liver. Virological testing (PCR and virus isolation methods) demonstrated the presence of ranavirus, adenovirus and invertebrate iridovirus.
Vet Rec 2013 Sep 14
PMID:Mass-mortality in green striped tree dragons (Japalura splendida) associated with multiple viral infections. 2397 85

The Human Animal Infections and Risk Surveillance (HAIRS) group is a collaboration between a number of human and animal health organisations within the UK government. The group aims to provide a 'joined-up' response to emerging diseases that threaten the health of people or animals. Here, Dilys Morgan, who chairs the group, discusses its work, highlighting its response to Schmallenberg virus, and shows how a One Health approach can improve government responses to potential crises.
Vet Rec 2014 Jul 19
PMID:One Health in action: the work of the HAIRS group. 2503 81