Gene/Protein Disease Symptom Drug Enzyme Compound
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 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this paper is to present rather than resolve some new ethical problems which are likely to become the subject of public discussion in the near future. Some problems likely to be the subjects of extensive debate are: the foetal patient, 'home abortifacients' and abortifacient vaccines, the withdrawal of life-sustaining treatment, experimentation on 'spare' human embryos, the legalization of heroin abuse and the use of anencephalics and the persistently comatose as organ donors.
Australas Cathol Rec 1990 Oct
PMID:Some new problems in biomedical regulation. 1599 9

Dopamine (DA) is involved in drug reinforcement, but its role in drug addiction remains unclear. Positron emission tomography (PET) is the first technology used for the direct measurement of components of the dopaminergic system in the living human brain. In this article, we reviewed the major findings of PET imaging studies on the involvement of DA in drug addiction, especially in heroin addiction. Furthermore, we summarized PET radiotracers that have been used to study the role of DA in drug addiction. To investigate presynaptic function in drug addiction, PET tracers have been developed to measure DA synthesis and transport. For the investigation of postsynaptic function, several radioligands targeting dopamine one (D1) receptor and dopamine two (D2) receptor are extensively used in PET imaging studies. Moreover, we also summarized the PET imaging findings of heroin addiction studies, including heroin-induced DA increases and the reinforcement, role of DA in the long-term effects of heroin abuse, DA and vulnerability to heroin abuse and the treatment implications. PET imaging studies have corroborated the role of DA in drug addiction and increase our understanding the mechanism of drug addiction.
Anat Rec (Hoboken) 2012 May
PMID:Positron emission tomography molecular imaging of dopaminergic system in drug addiction. 2246 95