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 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ultrastructural changes in hepatocytes of rats subjected to selective biliary obstruction (SBO), wherein the biliary system draining approximately two-thirds of the liver is obstructed, were evaluated by quantitative electron microscopy or stereology. The remaining unobstructed portion of the organ compensates for this loss of bile secretion by functioning in a hypersecretory mode. This animal model permits the comparison of hepatocellular fine structure associated with the conditions of nonsecretion and hypersecretion of bile with that found in normal secreting sham-operated rats. Since recent evidence suggests the presence of lobular gradients in hepatic structure and function, both centrolobular and periportal hepatocytes were examined. The low incidence of Golgi membrane profiles in high magnification electron micrographs results in a low confidence level of sampling and, thus, necessitates the application of a novel parameter for estimating the amount of Golgi complex, i.e., the Golgi-rich area. For the most part, the lobular variation in hepatic fine structure in the sham-operated animals was similar to that described by Loud ('68). However, the periportal parenchyma contained approximately twice the volume of Golgi-rich area as the centrolobular tissue. The amount of cytoplasmic lipid increased significantly in the SBO unobstructed lobes, although there were few or no changes in the other intracellular organelles or inclusions except those related to the Golgi complex. The volume of Golgi-rich area increased significantly in the centrolobular tissue of the SBO unobstructed (hypersecretory) lobes to the extent that both intralobular zones contained similar amounts of this component. These data suggest that the Golgi complex is a dynamic unit which responds to changes in hepatocellular activity and may be involved in bile secretion.
Anat Rec 1978 Oct
PMID:A quantitative analysis of hepatic ultrastructure in rats during enhanced bile secretion. 71 1

The paper describes a case of jaundice in a three-year-old bassett hound. The illness was accompanied by hyperbilirubinaemia and raised serum levels of alkaline phosphatase and glutamic pyruvic transaminase, indicating the presence of both biliary obstruction and hepatocellular damage. Examination of liver biopsies on two occasions showed intrahepatic cholestasis and mild inflammatory change. The dog was treated with corticosteroid. The jaundice regressed after three months, hepatic functions returned to normal and the dog recovered. The cause of the jaundice was not determined.
Vet Rec 1975 Nov 15
PMID:Intrahepatic cholestasis in a dog: a clinicopathological study. 120 93

Routine light microscopy and transmission and scanning electron microscopy were used to describe and compare the biliary tree of larval Lampetra lamottenii before and during infestation of the bile ducts with the nematode, Truttaedacnitis stelmioides. The most prominent changes to the biliary tree following infection by the parasite are the dilation of the bile ducts, alterations to their epithelial cells, and an increase in periductal fibrous tissue. In recently infected animals, the simple epithelium of dilated bile ducts often contains many mitotic figures. In long-term infestations, the epithelium is stratified or pseudostratified. Changes to the fine structure of the biliary epithelial cells include increase and/or dilation of the RER and SER, and increases in microfilaments, intermediate filaments, and microtubules. The abundance of dense bodies may reflect enhance reabsorption of biliary constituents, and their accumulation may ultimately result in cytolysis. There are increased mucous granules in the apical cytoplasm of biliary epithelial cells and an abundance of mucinous material within the bile duct lumen, and the basal lamina appears thickened. The changes to the liver of L. lamottenii following infection are discussed and compared to those reported in small mammals following bile duct ligation, in patients with extrahepatic biliary obstruction, and in parasitic infection of the biliary tree.
Anat Rec 1992 Oct
PMID:Morphology of the bile ducts of the brook lamprey, Lampetra lamottenii (Le Sueur) before and during infection with the nematode, Truttaedacnitis stelmioides (Vessichelli, 1910) (Nematoda: Cucullanidae). 141 6

Two dogs with pancreatic pseudocyst or pancreatic abscess formation were treated by transgastric cystogastrostomy. In each case drainage of the cyst/abscess cavity into the stomach was followed by resolution of the primary lesion. One dog succumbed to an E coli bronchopneumonia after infection of the deep venous line used for total parenteral nutrition. The second dog recovered despite requiring additional surgery for biliary obstruction. Both dogs required intensive care during and after the operation.
Vet Rec 1989 Aug 19
PMID:Cystogastrostomy in the treatment of pancreatic pseudocyst/abscess in two dogs. 250 97

The history, clinical signs and radiographic and ultrasonographic findings in 16 dogs with pancreatic neoplasia were reviewed retrospectively. Thirteen of the dogs had islet cell carcinoma compatible with insulinoma, one had a pancreatic adenocarcinoma and two had secondary invasion of the pancreas, one by a gastric carcinoma and one by an intestinal lymphoma. The clinical signs in the 13 dogs with insulinoma included collapse in 10 dogs, ataxia in seven, weakness in five, and seizures in two. Two of the 16 dogs had jaundice due to biliary obstruction by the primary tumour or metastases. The sensitivities for pancreatic neoplasia were three of 16 (19 per cent) for radiography and 12 of 16 (75 per cent) for ultrasonography; the sensitivities for metastasis were two of 11 (18 per cent) for radiography and six of 11 (55 per cent) for ultrasonography. Biliary obstruction was detected by ultrasonography in both affected dogs.
Vet Rec 1995 Jul 15
PMID:Ultrasonography of pancreatic neoplasia in the dog: a retrospective review of 16 cases. 853 34