Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pectineus muscle resection was performed on 100 dogs with hip dysplasia. The degree of dysplasia was estimated by radiography and by joint manipulation. The effects of the procedure on 81 dogs were determined by personal reinspection (34), or by means of owner-reports (47). Improvement was noted in 80 per cent but only 35 per cent reached a high level of recovery. The operation has a role in the treatment of hip dysplasia but it does not cure the condition and it will be several years before the long-term results are known.
Vet Rec 1975 Feb 15
PMID:Pectineus muscle resection as a treatment for hip dysplasia in dogs. 111 74

Bovine spongiform encephalopathy was not confirmed histologically in 225 of 829 bovine brains submitted for diagnosis. Several previously described disorders of the central nervous system were observed in these brains as well as disorders not previously recognised in Britain, including bilateral vacuolation of the substantia nigra, hippocampal sclerosis with brainstem neuronal chromatolysis and necrosis, focal symmetrical encephalomalacia and meningio-angiomatosis. Severe cerebellar dysplasia consistent with pre-natal bovine viral diarrhoea--mucosal disease virus infection or mineralisation of the blood vessels of the basal ganglia were interpreted respectively as congenital changes or changes due to ageing and were considered to be of no clinical significance.
Vet Rec 1992 Oct 10
PMID:A neuropathological survey of brains submitted under the Bovine Spongiform Encephalopathy Orders in Scotland. 144 Nov 43

Aortic valvular dysplasia, a congenital abnormality not previously reported in cattle, was diagnosed in a calf with a pulsating mass at the base of its neck, an enlarged area of cardiac dullness and a loud (grade IV/V) systolic cardiac murmur. Electrocardiography and thoracic radiography demonstrated that the left atrium and ventricle were enlarged. Dysplasia of two aortic valve cusps and post stenotic dilatation of the ascending aorta were identified by echocardiography and confirmed post mortem.
Vet Rec 1991 Oct 26
PMID:Aortic valvular dysplasia in a calf. 174 15

German wirehaired pointers, English, Irish and Gordon setters, and labrador retrievers that were puppies during the spring and summer had a significantly lower incidence of hip dysplasia than those growing up during the autumn and winter. However, golden retrievers and German shepherd dogs did not show the same seasonal pattern of incidence of hip dysplasia.
Vet Rec 1991 May 04
PMID:Hip dysplasia in dogs in relation to their month of birth. 185 36

With advancing years a dog may suffer from a variety of conditions of its musculoskeletal system which adversely affect its ability to exercise and may cause it to be retired from activities in work and sport for which it has been trained. Arthritis is common, and in many cases arises from developmental errors suffered in puppyhood, such as hip dysplasia, osteochondrosis and growth plate disorders. Trauma to joints (ligament ruptures, dislocations and fractures) may also be the precursor of degenerative joint changes later in life. It is important, therefore, for all such conditions to be corrected as effectively as possible if joint disease is to be minimised as the dog grows older. Preventive action is also required for some conditions for which correction may not be entirely feasible, so the identification of modes of inheritance is important if those are to be controlled by breeding. Certain spinal disorders also tend to increase in prevalence with age, particularly spondylosis deformans, neoplasms and chronic degenerative radiculomyelopathy. As it happens, spondylosis in mild to moderate degree affects pet dogs very little, but a reduction in spinal flexibility can cause problems for dogs required to be agile in work or sport. In common with other body tissues, neoplasm of the locomotor system increases in occurrence in older dogs, and although the overall incidence of tumours of bones, joints, nervous tissue and muscle is relatively low, these are the most serious of all the limb and spinal conditions encountered because of their life threatening propensities. The treatment required covers a wide range from simple changes of management in order to reduce exercise, to the use of analgesics and anti-inflammatory drugs and to surgery to remove diseased tissue, stabilise joints or reduce pain with forms of arthroplasty or arthrodesis.
Vet Rec 1990 Apr 21
PMID:Orthopaedic problems in old dogs. 219 52

A new form of bilateral renal dysplasia in lambs appeared in a commercial sheep flock in 1982. The nature of the problem, the field investigations and the laboratory examinations carried out over three lambing seasons are described. It was concluded that the condition was vertically transmitted and genetic in origin. During the two years that accurate records were kept approximately 30 per cent of the suspected ram's progeny died with lesions of renal dysplasia. The condition recurred during a breeding trial in progeny from one of the two commercial rams originally used on the farm. An autosomal dominant mode of inheritance is suggested. The incidence illustrates the importance of keeping breeding records, especially when several rams are maintained in a flock, and the value of examining a large number of lambs post mortem.
Vet Rec 1990 Oct 27
PMID:A vertically transmitted cystic renal dysplasia of lambs. 226 43

The events which followed the introduction of a heifer into a dairy herd were consistent with the animal being persistently infected with bovine diarrhoea-mucosal disease virus. Obvious damage was limited to the progeny of cows which were in the first 168 days of gestation at that time. Only fetuses up to 81 days of gestation at the putative time of introduction of infection became persistently infected in calfhood and, although they exhibited body tremor, two such calves necropsied at three months of age lacked macroscopic or microscopic lesions in the central nervous system. In contrast calves which had been more advanced in gestation, at 146 and 153 days at the time of infection, had eliminated the infection and had lesions of cerebellar dysplasia and multifocal retinal atrophy.
Vet Rec 1986 Jan 11
PMID:Pestivirus fetopathogenicity in cattle: changing sequelae with fetal maturation. 375 9

Details are given of the clinical, radiological and pathological appearance of dwarf lambs. Twenty-seven of 110 lambs born were affected, occurring as singletons, twins or one of a pair of twins. All affected lambs were dead within a few minutes of birth. They were short and plump with a domed head and shortened nose, short paddle-like limbs, a narrow thorax and swollen abdomen. The defect involved chondrocyte dysplasia, producing defective endochondral ossification and the presence of abnormal cartilage in the respiratory tract. No specific genetic or environmental cause was identified.
Vet Rec 1985 Nov 30
PMID:Skeletal abnormality of sheep: clinical radiological and pathological account of occurrence of dwarf lambs. 409 Feb 4

Renal dysplasia is reported in two adult horses in chronic renal failure. Renal dysplasia, complicated by severe interstitial pyelonephritis, was diagnosed on renal biopsy and confirmed on post mortem examination.
Vet Rec 1993 Mar 13
PMID:Renal dysplasia in two adult horses: clinical and pathological aspects. 846 3

Purebred dog populations have been subject to strong selection which has resulted in extreme differences between breeds and decreased heterogeneity within breeds. As a result, breed-specific inherited diseases have accumulated in many populations. The aim of this study was to analyse genetic heterogeneity in relation to the distribution of elbow dysplasia in labrador retrievers, portosystemic shunts in Irish wolfhounds, and hepatic copper toxicosis, in Bedlington terriers. Decreased heterogeneity was demonstrated in the multiple genetic interrelations in the three populations. In pedigrees containing seven generations of ancestors, the average number of common ancestors in all pair-wise combinations of dogs was five to six (range 0 to 18). These complex interrelationships were resolved by a cluster analysis on matrices of relatedness. This analysis gave clusters of highly related animals, the average relatedness of these clusters, and the average relatedness of the entire population, as expressions of its genetic variability. The mean relatedness was 0.032 for Irish wolfhounds and Bedlington terriers, and 0.002 for labrador retrievers. The labrador retriever cohort was resolved into 31 clusters, and all cases of elbow dysplasia were concentrated in five highly related clusters with an overall incidence of 17 per cent. The Bedlington terrier cohort consisted of 12 clusters which all contained cases of copper toxicosis, with an overall incidence of 46 per cent. The Irish wolfhounds were divided into 14 clusters with a disease incidence of 4 per cent. Dogs with portosystemic shunts were found in four averagely related clusters. A genetic distribution became obvious only when relatedness due to common ancestors of the cases was used as a criterion, and the cases were then concentrated in five highly related clusters.
Vet Rec 1998 Feb 28
PMID:Cluster analysis of the genetic heterogeneity and disease distributions in purebred dog populations. 953 91


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