Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adult male rats were administered hydroxy-cobalamin (c-lactam) (HCCL), a vitamin B12 analogue, by means of osmotic mini-pumps. The metabolic effects of HCCL are similar to those produced by simple dietary deficiency of vitamin B12 (Frenkel et al., 1976), but the morphological alterations in hepatic mitochondria are quite different in the two treatments. In HCCL-treated animals, hepatic mitochondria showed significant increases in number. In one rat, the hepatic mitochondria frequently had a single, elongated, circumferentially-oriented crista, with the inner compartment being occupied by a greatly augmented matrix. Such organelles appeared to be capable of division, as indicated by medially-partitioned forms. Numerous hooded mitochondria were present in the hepatic cells of the same animal. Almost every mitochondrion of whatever morphology was partially or completely shrouded by a cistern of rough endoplasmic reticulum. These mitochondrial morphological changes may be related to the chronic metabolic changes in this animal model of methylmalonic aciduria.
Anat Rec 1991 Sep
PMID:Unusual mitochondria in the hepatocytes of rats treated with a vitamin B12 analogue. 166 Nov 7

Sixty male weaner cattle at the National Range Research Station, Kiboko, Kenya were placed in four groups of 15 animals under four different tick control regimens for 16 months. The treatment groups were: spraying with acaricide weekly, spraying every three weeks, spraying whenever group mean tick infestations reached more than 200 per animal (once only in the course of the study) and a control unsprayed group. The cattle were weighed monthly. There were no significant differences between the liveweight gains of the groups during a period of severe drought and during the following period of compensatory weight gain. The untreated group gained more weight than the other groups. Cattle died in all groups, but without significant differences between the groups; the long drought and associated malnutrition were the prime cause of death. Rhipicephalus pravus and R pulchellus were the dominant tick species with fewer Amblyomma gemma, Hyalomma truncatum and small numbers of Boophilus decoloratus and R evertsi. These ticks transmit anaplasmosis, babesiosis and cowdriosis in the study area. Total tick counts reached 750 on individual animals but group means rarely reached more than 200 because of high resistance to ticks in some animals. Host resistance ranking within groups was virtually constant throughout the experiment. The study showed that intensive tick control is not required in the semi-arid areas of Africa.
Vet Rec 1986 Oct 18
PMID:A study of the justification for intensive tick control in Kenyan rangelands. 379 81

This paper reports seven cases of penile paraphimosis which occurred in both entire and castrated horses in association with general debility. Two cases were discharged after treatment while still suffering from partial paralysis; one was discharged at the owner's request with complete paralysis; three were destroyed and one died during treatment. Identified causes of debility were malnutrition, severe parasitism, glucose malabsorption and salmonellosis.
Vet Rec 1985 Feb 02
PMID:Paraphimosis in seven debilitated horses. 398 75

In 1980, 16 abortions or stillbirths occurred and 26 deformed calves were born in a beef herd of 115 Friesian cross Hereford cows mated to Charolais bulls. The deformities were principally arthrogryposes with contractures, particularly of the forelimbs, and various skull abnormalities. Following investigation it was considered highly unlikely that hereditary causes, infectious agents or a nutritional deficiency were responsible. The most likely cause was exposure to an unidentified teratogen early in pregnancy.
Vet Rec 1985 Mar 16
PMID:High incidence of abortions and congenital deformities of unknown aetiology in a beef herd. 399 30

Two cases of obstructive urethral calculi in the male dromedary camel are reported. Infection, metabolic disorders, malnutrition and climatic stress are cited as possible causes. The diagnosis and the surgical treatment of this condition are discussed, with particular reference to the anatomy of the camel's penis.
Vet Rec 1985 Nov 09
PMID:Obstructive urethral calculi in the male camel: report of two cases. 408 97

Parenteral treatments can provide a rapid successful method of supplementing ruminants with copper and selenium, and avoid the possible interactions between an oral supplement and other dietary constituents. The copper preparations studied contained copper complexed with calcium edetate (EDTA) or copper methionate , copper oxide or copper oxyquinoline sulphonate. The recommended doses of these commercial preparations contain different amounts of copper only part of which is transferred to the liver stores from which it can be released during the following months. The recommended dose of copper oxyquinoline sulphonate contains only 12 mg copper and the duration of its protective effect is short. Only a small proportion of the copper in copper methionate and copper oxide is transferred to the liver whereas nearly all the copper in a single dose of the EDTA complex (50 mg copper for sheep) is transferred to the liver stores. Although no longer recommended for use in sheep the copper EDTA complex can be administered to cattle to provide up to 1 mg copper/kg bodyweight. Selenium deficiency in both cattle and sheep can be corrected by the subcutaneous administration of up to 0.15 mg selenium/kg bodyweight as sodium selenate. However, if a dietary deficiency persists copper and selenium treatments are effective for only a few months. To avoid the need for repeated treatments, slowly dissolving or controlled release systems have been developed. Subcutaneous depots of barium selenate have been used (1 mg selenium/kg bodyweight) but large residues remained at the site of injection for up to three months. Initial trials with controlled release glasses containing copper have shown that they maybe useful for routine parenteral therapy.
Vet Rec 1984 May 05
PMID:Parenteral methods of supplementation with copper and selenium. 673 Feb 68

A condition of protein-calorie malnutrition was precipitated in young Sprague-Dawley male rats at 20 days of age using an 8% low protein diet (LPD). At five-day intervals for up to 50 days of age, the rats were studied to determine the effect of an LPD on the reproductive axis of the endocrine system. Daily monitoring of the body weight, as well as the consumption of food, kilocalories, and protein was conducted. The same parameters were followed over the identical time period in a group of animals desigated as controls which were fed a standard laboratory diet (SLD) containing 27% protein. The controls showed a linear growth rate over the 30-day experimental period. In comparison, the malnourished rats grew more slowly so that by 50 days of age, their mean body weight was 68.9 +/- 3.1 g as compared to 248.1 +/- 6.1 g for the controls. The daily food, kilocalorie, and protein intake by the experimental animals were also appreciably less. The pituitary gland, ventral prostate gland, testes and liver were smaller in the animals fed the LPD. This was observed as early as five days after initiating the dietary regimes and remained a consistent observation until the end of the experiment. In general, the absolute weights of these organs in the 50 day-old malnourished rats were similar to those found in 25 to 26-day-old animals fed the SLD. The relative weights of the pituitary gland and liver remained similar between the two animal groups. The testes and ventral prostate gland, however, were relatively smaller in the malnourished animals at nearly every time interval studied. On light microscopic examination of the testes, it was found that normal maturation of the germ cells failed to occur in all but one of the experimental animals, whereas maturation proceeded normally in the rats fed the SLD. Serum luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), and testosterone were lower in the malnourished animals at all ages studied. These hormones not exhibit the fluctuations that were seen in the controls and are typical in rats that are becoming sexually mature. The effect of protein deficiency on the concentration of the pituitary gonadotrophins was more varied. FSH concentrations were consistently lower, PRL was moderately affected, and LH remained essentially unchanged. Hypothalamic LH-releasing hormone was measured and found to be significantly less in the rats fed the LPD at most of the time intervals examined. These results indicate that the hypothalamo-hypophyseal-gonadal axis is impaired when the consumption of proteins and calorie is decreased. The possible involvement of extrahypothlamic centers in the control of hormone secretion in the protein-deficient rat is discussed.
Anat Rec 1980 Jul
PMID:Growth patterns and hormonal profile of male rats with protein-calorie malnutrition. 677 47

Mannosidosis, an inherited and lethal lysosomal storage disease of Aberdeen Angus cattle, was diagnosed on a farm in north-east Scotland. Two affected calves were examined in detail. Both were poorly grown and ataxic, though the intention tremor and aggression considered characteristic of the disease were not recorded. Histological examination revealed typical vacuolation of nerve cells, fixed macrophages and epithelial cells of the viscera. Deficiency of the enzyme alpha mannosidase was demonstrated. The epidemiology of the disorder in Scotland is considered and control methods indicated.
Vet Rec 1981 Nov 14
PMID:Mannosidosis in Aberdeen Angus cattle in Britain. 730 58

A quantitative analysis of the pituitary gland was conducted to ascertain the effects of protein-calorie malnutrition on the morphology of the somatotrophs, gonadotrophs, thyrotrophs, and corticotrophs. Male rats were fed a low, 8% protein diet from 20 to 50 days of age, while their age-matched controls were given a diet containing 27% protein. The hypophyses were then processed for light microscopic immunocytochemical staining using antibodies to growth hormone, the beta subunits of luteinizing hormone and thyroid stimulating hormone, and adrenal corticotrophic hormone. The number of each cell type along with an evaluation of the cell, cytoplasmic, and nuclear areas was conducted using a computerized image analyzer. All of these parameters were reduced significantly in the somatotrophs as a result of the low protein diet, while in the gonadotrophs, the cell, cytoplasmic, and nuclear areas were similarly affected. Smaller cell number, cell area, and nuclear area were noted in the corticotrophs of the malnourished animals, while in the thyrotrophs, only the cell and nuclear areas were reduced. The data demonstrate that each pituitary cell type responds in a unique manner to undernutrition.
Anat Rec 1993 Jan
PMID:Quantitative morphological analysis of the pituitary gland in protein-calorie malnourished rats. 841 20

This paper presents puppy mortality and postmortem findings for a birth cohort of boxer puppies born in the Netherlands between January 1994 and March 1995. In all, 457 litters were registered, of which 414 (90.6 per cent) were involved in the study. The 414 litters contained 2629 puppies, a mean litter size of 6.4 puppies. Of the 2629 puppies 571 (21.7 per cent) died or were euthanased before they were weaned at 50 days of age; there were 147 (25.7 per cent) stillbirths; 102 (17.9 per cent) were euthanased because they were white; 269 (47.1 per cent) of the puppies died during the first 21 days of life and 53 (9.3 per cent) puppies died between days 22 and 50. The cause of death or the reason for euthanasia was assessed by either the breeder or the veterinarian in 176 of these 269 puppies but was not determined in the other 93 puppies. Three hundred and two puppies were examined postmortem; the most important cause of death or reasons for euthanasia were inflammatory disorders (102; 33.8 per cent), non-inflammatory disorders such as asphyxia and malnutrition (66; 21.9 per cent), euthanasia because they were white (51; 16.9 per cent), and congenital abnormalities (45; 14.9 per cent). No cause of death or reason for euthanasia could be found for 38 puppies (12.6 percent)
Vet Rec 1998 May 30
PMID:Investigation of mortality and pathological changes in a 14-month birth cohort of boxer puppies. 968 19


1 2 Next >>