Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The inoculation of 2000 colony-forming units of Corynebacterium pseudotuberculosis into one teat canal of each of three cows resulted in severe, chronic, pyogranulomatous mastitis. Within three days the cows had a reduced haematocrit, haemoglobin concentration and red cell count. The anaemia was initially normocytic, normochromic and non-regenerative, and was associated with a brief peak of neutrophilia; a regenerative response became evident two to three weeks later. Clinical signs of mastitis appeared seven to 14 days after the inoculation, with a peak of high fever, more severe anaemia, a second peak of neutrophilia and the complete cessation of milk production from all quarters; extensive and severe pyogranulomatous mastitis developed in the inoculated quarters. No other lesions were detected postmortem, and C pseudotuberculosis was cultured from the affected quarters but not from the supramammary lymph nodes and viscera.
Vet Rec 2003 Dec 13
PMID:Experimental Corynebacterium pseudotuberculosis mastitis in dairy cows. 1470 79

In an effort to control the spread of caseous lymphadenitis (CLA) infection, flocks of affected sheep on six holdings were tested serologically at regular intervals using an antibody ELISA with a mean (sd) specificity of 99 (1) per cent and a sensitivity of 79 (5) per cent. Western blot assays to detect antibodies to the phospholipase D (PLD) exotoxin of Corynebacterium pseudotuberculosis were used as a further test when ELISA results were inconclusive. Owners were advised to remove from the flock any sheep that demonstrated clinical signs of CLA or tested positive for PLD by ELISA or western blot. Of the six trial flocks, one was dispersed after only two blood tests, and in another the recommendations for CLA control were not followed and infected animals were retained within the flock. In the remaining four flocks, the testing regimen and other advice enabled the disease to be controlled to such an extent that the appearance of new clinical cases of CLA was effectively halted. This remained the case for up to five years after the end of the trial. In two of these flocks, a small number of seropositive animals were detected at the last flock test). However, on the other two holdings all sheep were seronegative in the final two flock tests, consistent with the complete eradication of infection.
Vet Rec 2010 Mar 20
PMID:Control of caseous lymphadenitis in six sheep flocks using clinical examination and regular ELISA testing. 2030 91


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