Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
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The most commonly encountered nutritional bone disease is nutritional secondary hyperparathyroidism. This is primarily of importance in the dog but is occasionally seen in kittens, particularly of the Siamese breed, and is often associated with the feeding of owner compiled, meat-rich diets. Classic rickets is now a rare clinical entity. Hypertrophic osteodystrophy is regularly seen in the larger breeds of dog and the aetiology remains obscure. Hypervitaminosis A associated with liver-rich diets is often encountered in the cat. Hypovitaminosis A has been described but its true clinical significance is unknown.
Vet Rec 1976 Apr 17
PMID:Nutrition and bone disease in the dog and cat. 77 53

Thickening of the cranial vault with a resulting cerebellar herniation is described in a series of litters of lion cubs, all with the same parents, one of whom was also very mildly affected. This animal, when mated to his daughter, also produced affected cubs. The aetiology of the condition is discussed and it is considered that vitamin A deficiency may have been less important than has been suggested by other authors.
Vet Rec 1977 Feb
PMID:Skull malformation and cerebellar herniation in captive African lions. 84 79

Six pairs of alipochromatic ('recessive-white') canaries (Serinus canaria) and six pairs of coloured canaries were kept through a complete breeding cycle while being fed a diet providing 12,000 iu vitamin A/kg. The eggs of three pairs (one recessive-white and two coloured) were all unfertilised and there were only 23 hatchlings (14 recessive-white and nine coloured), of which 14 (10 recessive-white and four coloured) were alive after the first moult. However, there was no clinical, biochemical or pathological evidence that the recessive-white canaries were suffering from vitamin A deficiency or that the coloured canaries were suffering from vitamin A toxicity, suggesting that the diet met the vitamin A requirements of both groups.
Vet Rec 2007 Jan 06
PMID:Vitamin A requirements of alipochromatic ('recessive-white') and coloured canaries (Serinus canaria) during the breeding season. 1720 90

Hypovitaminosis A responsible for ocular deformities in suckler calves A review of type D clostridial enterotoxaemia in cattle Nitrate/nitrite poisoning in kale fed lambs Louping ill in sheep in mid-winter Rhodococcus equi abscessation identified at meat inspection of fattening pigs These are among matters discussed in the disease surveillance report for December 2013 from SAC Consulting: Veterinary Services (SAC C VS).
Vet Rec 2014 Mar 08
PMID:Range of ocular deformities in calves due to hypovitaminosis A. 2473 21