Gene/Protein Disease Symptom Drug Enzyme Compound
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A new clinicopathological disorder associated with a paramyxovirus infection in pigs is described. Central nervous system manifestations and corneal opacity are the main features in piglets two to 21 days old. Older pigs seem to be more resistant and only corneal opacity is commonly observed. In pregnant sows the virus appears to be responsible for reproductive disturbances such as stillbirth, mummification and a return to oestrus. The changes are mainly microscopic and characterised by a non-suppurative encephalomyelitis, interstitial pneumonia and anterior uveitis with corneal oedema. Experimental infection of one-day-old piglets with the virus reproduced clinical signs similar to those described in naturally infected piglets. The virus was recovered from the tonsils, lung and brain of the experimentally infected piglets between the fourth and 20th day after infection.
Vet Rec 1988 Jan 02
PMID:Encephalomyelitis, reproductive failure and corneal opacity (blue eye) in pigs, associated with a paramyxovirus infection. 336 9

Diffuse clouding of the cornea ('corneal oedema', 'blue eye') of sudden onset and usually transient duration and with accompanying anterior uveitis, may be attributable to natural infection with canine adenovirus type 1 (CA-1) or to vaccination with live modified virus. It is now recognised that kerato-uveitis is a manifestation of type III hypersensitivity in which immune complex formation resulting from the release of virus, especially from infected corneal endothelial cells, brings about corneal endothelial damage and hence corneal oedema. A proportion of cases fail to resolve. At least one breed, the Afghan hound, appears to be particularly susceptible. The incidence of ocular lesions resulting from vaccination has stimulated the development of new vaccines incorporating canine adenovirus type 2 (CAV-2), a serotype which has been shown not be cause endogenous ocular disease.
Vet Rec 1983 Apr 09
PMID:The 'blue eye' phenomenon. 630 88