Gene/Protein Disease Symptom Drug Enzyme Compound
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A disease causing increased mortality and abortion in domestic animals during a 1977 epizootic in Egypt was identified as Rift Valley fever (RVF) virus. The epizootic included extensive human involvement reflected clinically as either an acute febrile, ocular, encephalitic, or fatal haemorrhagic form of RVF disease. The virus was again isolated from humans and animals during a second RVF epizootic in the summer of 1978.
Vet Rec 1979 Aug 11
PMID:An epizootic of Rift Valley fever in Egypt in 1977. 50 18

Epidemic Rift Valley fever is generally recognised when a higher than expected frequency of abortions and haemorrhages occurs in sheep and other livestock. Other infectious agents can cause similar clinical signs. In Egypt, an outbreak of abortions and haemorrhages in sheep and goats in 1982 was traced to intoxication with the rodenticide brodifacoum. The epidemic lasted for three weeks and resulted in 120 deaths. The end of the epidemic coincided with a heavy rainstorm. This outbreak demonstrates the need for the strict control of the use of rodenticides and widens the differential diagnosis of epidemic abortion in sheep and goats.
Vet Rec 1986 Mar 08
PMID:Rodenticide-induced signs simulating Rift Valley fever in sheep and goats in Egypt. 396

Animal production is important for the agricultural economy in low-income countries, but is threatened by infectious diseases. Serosurveys are conducted for different reasons such as disease detection, risk factor studies, disease monitoring and establishing disease-free status. Most reports on such serosurveys include some discussion about methodological constraints but still, by necessity, rely on serological results for case definition. This study uses a cross-sectional serosurvey for foot-and-mouth disease (FMD), Rift Valley fever (RVF) and contagious bovine pleuropneumonia (CBPP) in cattle in three districts in Western Uganda to illustrate the limitations of this approach, addressing the questions of what flaws can be expected in sampling and diagnostics and how these influence the results. The target was to collect blood samples from 60 cattle herds per district. To reflect the recent infection history of the herd, young animals (two to five years) were prioritised. The farmers were interviewed about management, cattle trade, cattle health and vaccination. Commercial ELISAs were used for serological analyses: for CBPP the IDEXX CBPP Mycoplasma mycoides subspecies mycoides antibody test kit, for RVF the ID Screen Rift Valley Fever competitive ELISA, and for FMD the PrioCHECK FMDV NS. Apparent prevalence, true prevalence and associations with herd characteristics were assessed. The sampling plans could not be entirely fulfilled, nor the number of tests run in the laboratory. There were reactors to all three diseases with an apparent prevalence of approximately 30 per cent for CBPP, 6 per cent for RVF and 7 per cent for FMD. Calculation of true prevalence based on test sensitivity and specificity resulted in a slightly higher prevalence figure for CBPP and lower figures for RVF and FMD. The study illustrates the importance of considering diagnostic test performance when interpreting results from serosurveys, and the challenge of representative sampling and laboratory work in low-income countries.
Vet Rec Open 2018
PMID:Methodological aspects of serosurveillance in resource-poor settings. 2968 93