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In late November 1988 large numbers of thoroughbred horses in training in Hong Kong developed a transient pyrexia with, in some cases, the clinical signs of viral respiratory disease. Serial blood samples for haematological examination were taken from 10 of the horses which were stabled in six different blocks. They had developed a high temperature within three days of each other and subsequently seroconverted to equine herpes virus 1 (EHV1). The absolute monocyte count was more than 0.5 x 10(9)/litre in all 10 within the first five days, and nine of them had a high neutrophil/lymphocyte ratio on the first day, which then decreased and reversed within four or five days. Five of the horses had a high plasma viscosity, and a large difference between the viscosity of plasma and serum which in three of them returned to normal within 10 days. In the two and a half months after the initial infection six of nine of the horses, including the five which had a large difference between the viscosity of plasma and serum, developed visible mucopus by endoscopic examination. These haematological and endoscopic changes can be used to detect horses in the acute stages of EHV1 infection and monitor the progress of the disease, before it can be confirmed by isolation of the virus and, or, serology.
Vet Rec 1990 Apr 14
PMID:Haematological measurements as an aid to early diagnosis and prognosis of respiratory viral infections in thoroughbred horses. 215 70

The neutralisation patterns of 103 recent isolates of feline calicivirus from cats with chronic stomatitis or acute feline calicivirus disease, and from cats with neither oral nor respiratory disease were compared. There were no statistically significant differences between the proportions of isolates from each clinical source neutralised by individual feline calicivirus cat antisera. Different antisera showed widely differing degrees of cross reactivity; antisera to the most widely used vaccine strain F9 being the most cross reactive, neutralising 54 per cent of all the field isolates, and antisera to a field isolate LS015 the next most cross reactive, neutralising 29 per cent of the field isolates. However, the cross reactivity of antisera to early British isolates (A4, 68/40 and 69/1112) was much reduced (overall less than 10 per cent) whereas in the early 1970s 65 per cent of 117 field isolates from clinically normal cats were neutralised by A4 antiserum, and 40 per cent by each of 68/40 and 69/1112 antisera. This suggests a change in the spectrum of antigenicity among feline calicivirus isolates over the past 15 years. However, the cross reactivity of F9 antisera appeared to be similar to that in earlier studies. The relevance of these findings to vaccination is discussed.
Vet Rec 1990 Aug 11
PMID:Neutralisation patterns among recent British and North American feline calicivirus isolates from different clinical origins. 217 Nov 83

Two horses on separate farms developed severe obstructive pulmonary disease in successive years during the early summer months. In both cases clinical remission of the respiratory distress was achieved by moving the animals to different environments. The suggested aetiology for this outdoor chronic respiratory disease is a pulmonary allergy to pollen. Both animals were also shown to suffer from classical chronic obstructive pulmonary disease, i.e., obstructive pulmonary disease in the presence of hay and, or, straw.
Vet Rec 1990 Jan 06
PMID:Pasture-associated seasonal respiratory disease in two horses. 230 Nov 7

An outbreak of respiratory disease among thoroughbred horses in training in Hong Kong was caused by equine herpesvirus 1 (EHV-1) subtype 1 (abortion strain). Two of the horses affected by EHV-1 were serially blood sampled over a period of several weeks and their haematological values measured. There was an increase in monocyte count in the first few days which steadily decreased in one horse, but the other had a second monocyte peak after a period of exercise, thus demonstrating the importance of not working animals in the early stages of the disease.
Vet Rec 1989 May 13
PMID:Haematological changes in two thoroughbred horses in training with confirmed equine herpesvirus 1 infections. 254 64

An increase in deaths in calves from respiratory disease from an average of 9.7 per year to 36.5 per year corresponded with the isolation of Mycoplasma bovis from the lungs. It is suggested that this mycoplasma enhanced the severity of the disease which was normally present on the farm. The characteristic microscopic lesion and demonstration of M bovis by immunoperoxidase labelling could be useful aids to diagnosis.
Vet Rec 1989 Apr 22
PMID:Increased severity of calf pneumonia associated with the appearance of Mycoplasma bovis in a rearing herd. 275 19

Serum samples from pig herds in Great Britain have been examined for antibodies to influenza virus since 1968. Antibodies to H3N2 virus strains have been found since 1968 and the serological data presented here suggests that H3N2 virus strains continue to persist in the pig population. An outbreak of acute respiratory disease occurred in a 400-sow unit. The outbreak was characterised by coughing, anorexia, fever, inappetence and loss of condition. The gilts and weaners were affected and the morbidity approached 100 per cent. An influenza A virus designated A/Swine/Weybridge/117316/86 (H1N1) was isolated from the herd and 28 paired serum samples from the affected animals showed increases in the haemagglutination inhibition titres to this isolate. Haemagglutinin and neuraminidase characterisation indicated that the virus is similar to H1N1 viruses isolated recently from pigs in Europe. A total of 91 herds experiencing respiratory disease were investigated, of which 42 gave positive reactions in the haemagglutination inhibition test. Antibodies to A/Port Chalmers/1/73 (H3N2) were also detected in some of the herds but it is not known whether this strain plays any role in the current respiratory disease problems in pigs.
Vet Rec 1987 Jul 18
PMID:Outbreaks of classical swine influenza in pigs in England in 1986. 282 Jan 11

A quadrivalent vaccine containing the killed antigens of respiratory syncytial virus, parainfluenza virus type 3, Mycoplasma dispar and M bovis, emulsified with an oil adjuvant, was tested for efficacy against naturally occurring calf respiratory disease. Three batches of beef cattle aged 12, seven and three weeks at the time of first vaccination were used. Within each batch of approximately 100 animals, half were vaccinated subcutaneously on three occasions, three weeks apart and half served as unvaccinated controls. Over the trial period, from November 1981 to May 1982, 27 per cent of the control calves were treated for respiratory disease compared with 16.3 per cent of the vaccinated animals. This reduction of non-fatal disease in the vaccinated animals represented a protection rate of almost 40 per cent and was statistically significant (P less than 0.05). Mortality was also reduced from 3.4 per cent in the control calves to 1.9 per cent in the vaccinated animals but this difference was not statistically significant. During a major outbreak of disease associated with respiratory syncytial virus, the protection rate increased to 69 per cent (P less than 0.01). Furthermore, in the batch of cattle aged seven weeks at first vaccination there was significantly less pneumonic consolidation at death in the vaccinated animals than in the control animals (P less than 0.05).
Vet Rec 1987 Oct 10
PMID:Field trial of a quadrivalent vaccine against calf respiratory disease. 282 97

A field trial to assess the ability of two vaccines to protect calves against respiratory disease was carried out on a large beef rearing unit in southern England over the two winters of 1983 to 1984 and 1984 to 1985. A quadrivalent vaccine containing the killed antigens of respiratory syncytial virus, parainfluenza virus type 3, Mycoplasma bovis and M dispar or a vaccine containing only the respiratory syncytial virus component were inoculated into 246 and 245 calves, respectively; 245 calves remained as unvaccinated controls. The calves were reared in seven batches and outbreaks of disease occurred in five; significant protection was achieved in the four batches in which disease was associated with respiratory syncytial virus and M bovis infection, together or independently. The death rate from pneumonia was 9 per cent in the control group, 2 per cent in the calves inoculated with the quadrivalent vaccine (P less than 0.001), a protection rate of 77 per cent, and 3 per cent in the calves inoculated with the respiratory syncytial virus vaccine (P less than 0.01), a protection rate of 68 per cent. The proportion of calves receiving treatment for respiratory disease was 38 per cent in the control group, 25 per cent in the calves inoculated with the quadrivalent vaccine (P less than 0.001) and 27 per cent in the calves inoculated with the respiratory syncytial virus vaccine (P less than 0.01). The results show that protection against respiratory disease can be achieved by parenteral vaccination of calves with the appropriate inactivated microorganisms.
Vet Rec 1987 Oct 17
PMID:Protection against respiratory disease in calves induced by vaccines containing respiratory syncytial virus, parainfluenza type 3 virus, Mycoplasma bovis and M dispar. 282 66

Blood samples were taken from bull calves at two Meat and Livestock Commission performance testing centres, just after weaning at six months of age and at six weekly intervals until the end of the performance test seven months later. Sera were assayed by specific ELISAS for antibodies to bovine herpes virus 1 (BHV1), respiratory syncytial virus, parainfluenza 3 (Pi3) and adenoviruses A and B. Seroconversions between each sampling were related to the occurrence of clinical respiratory disease using chi-squared (chi 2) and relative risk (RR) analyses. In 294 bulls there were 123 cases of respiratory disease. Seroconversion to bovine respiratory syncytial virus (RR = 4.7, chi 2 = 96.3, P less than 0.001) and adenovirus A (RR = 1.8, chi 2 = 8.9, P less than 0.001) and adenovirus B (RR = 1.9, chi 2 = 5.6, P less than 0.05) were significantly associated with clinical respiratory disease. There was evidence that prior exposure to respiratory syncytial virus (RR = 0.4, chi 2 = 9.8, P less than 0.01) Pi3 (RR = 0.4, chi 2 = 12.8, P less than 0.01) and adenovirus A (RR = 0.7, chi 2 = 7.5, P less than 0.01) conferred some protection against respiratory disease after arrival at the centre. It is concluded that vaccination before weaning, at least against bovine respiratory syncytial virus, would be beneficial.
Vet Rec 1988 May 28
PMID:Associations between viral infection and respiratory disease in young beef bulls. 284 21

Lungworm-infected seeder calves were used on four 1.41 ha paddocks to ensure that groups of 11 calves would be exposed to a heavy challenge with Dictyocaulus viviparus. By the 39th day after turnout there was a serious episode of respiratory disease and a diagnosis of parasitic bronchitis was confirmed by post mortem and faecal examination. One group of trial calves was treated with netobimin administered in the drinking water at 2.8 mg/kg/day for seven consecutive days; another group received the same treatment supplemented with flunixin meglumine at 2.2 mg/kg/day for three days; a third group was given a single oral dose of 7.5 mg netobimin/kg; only emergency treatments were given to calves in the control group. The clinical response to the drinking water treatments was highly satisfactory and better than the response to the single oral treatment.
Vet Rec 1988 Oct 15
PMID:Netobimin in drinking water for treatment of bovine parasitic bronchitis: a field experiment. 297 13


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