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Fourteen outbreaks of pneumonia in sheep following dipping in carbolic dips were investigated at seven laboratories. Deaths commonly occurred between one and three days after dipping and fat young sheep of the Suffolk and Border Leicester breeds were most usually involved in outbreaks. The pneumonia was characterised by hyperaemic, oedematous and cyanotic lungs, and the main histological features were hyperaemia, fluid and cellular exudation into alveolar spaces, and widespread epithelialisation of alveolar walls. The microscopic changes differed from pneumonic pasteurellosis and no significant organisms were recovered from any of the lungs. One of 27 Dorset Horn lambs dipped in a batch of dip which had been incriminated in some episodes developed an epithelialising interstitial pneumonia, while two out of three Suffolk lambs dipped in twice the recommended strength of the same batch of dip became ill with severe pneumonia, apparently following skin absorption.
Vet Rec 1982 Jan 09
PMID:Pneumonia in sheep associated with dipping in carbolic dips. 707 12

To investigate to what extent healthy chickens and turkeys may be carriers of Pasteurella multocida, oral swabs were examined from birds in flocks with or without a history of avian pasteurellosis. In all 841 specimens were examined by cultural methods but 142 were also tested by mouse inoculation. P multocida was not found in specimens from normal healthy flocks but was recovered from some live chickens in known infected flocks and from dead turkeys on an infected farm. The implications of these findings are briefly discussed.
Vet Rec 1981 Mar 07
PMID:Investigation to determine whether healthy chickens and turkeys are oral carriers of Pasteurella multocida. 722 34

Thirty-four rat carcases from 11 poultry farms were examined for the presence of Pasteurella multocida; 14 out of 34 (41 per cent) proved positive after mouse inoculation, compared with five out of 34 (14 per cent) using media alone. No salmonellae were recovered from 27 rat carcases using enrichment media. Poultry pasteurellosis was present on two farms with infected rats and the same serotype was present in rats and poultry in those cases.
Vet Rec 1980 Oct 04
PMID:Pasteurella multocida infection of poultry farm rats. 746 90

A trial was conducted to compare the efficacy of intranasal vaccination in protecting goats against pneumonic pasteurellosis with intramuscular vaccination using an oil adjuvant vaccine, and a combination of the two methods. Forty goats were divided into four equal groups. Group 1 was vaccinated twice intranasally with formalin-killed Pasteurella haemolytica A2, group 2 was vaccinated twice intramuscularly with an oil adjuvant vaccine containing P haemolytica A7, and group 3 was initially vaccinated intranasally with the formalin-killed P haemolytica A2 followed by intramuscular vaccination with the oil adjuvant vaccine. In each group the two vaccinations were carried out four weeks apart. Group 4 was the unvaccinated control group. All goats were challenged intratracheally with 4 ml of an inoculum containing live P haemolytica A2 at a concentration of 1.3 x 10(7) colony forming units/ml two weeks after the last vaccination and were killed 14 days after the challenge. Although group 2 showed the highest clinical score following the challenge, deaths were observed only in group 3. Three goats in group 1 had pneumonic lung lesions, compared with six goats in group 2 and all the goats in groups 3 and 4. The lung lesions in group 1 were significantly (P < 0.05) less severe than in groups 3 and 4. Similarly, the lesions in group 2 were markedly less severe than in groups 3 and 4, although the differences were not significant. The difference between the extent of the lung lesions in the goats in groups 1 and 2 was not significant. Antibody against P haemolytica A2 in group 1 reached peak levels and was significantly (P < 0.01) higher than in the control group one week after the second vaccination, before declining.
Vet Rec 1998 Apr 18
PMID:Efficacy of intranasal administration of formalin-killed Pasteurella haemolytica A2 against intratracheal challenge in goats. 959 32

Mannheimia haemolytica is the aetiological agent of pneumonic pasteurellosis in small ruminants. The primary virulence factor of the bacterium is a leukotoxin (LktA), which induces apoptosis in susceptible cells via mitochondrial targeting. It has been previously shown that certain lktA alleles are associated either with cattle or sheep. The objective of the present study was to investigate lktA sequence variation among ovine and caprine M haemolytica strains isolated from pneumonic lungs, revealing any potential adaptation for the caprine host, for which there is no available data. Furthermore, we investigated amino acid variation in the N-terminal part of the sequences and its effect on targeting mitochondria. Data analysis showed that the prevalent caprine genotype differed at a single non-synonymous site from a previously described uncommon bovine allele, whereas the ovine sequences represented new, distinct alleles. N-terminal sequence differences did not affect the mitochondrial targeting ability of the isolates; interestingly enough in one case, mitochondrial matrix targeting was indicated rather than membrane association, suggesting an alternative LktA trafficking pattern.
Vet Rec 2013 Apr 20
PMID:Sequence diversity of the leukotoxin (lktA) gene in caprine and ovine strains of Mannheimia haemolytica. 2339 25

Leptospiral milk drop in dairy cows. Pseudomonas aeruginosa mastitis in a cow. Systemic pasteurellosis in lambs. Encephalopathy due to water deprivation/salt poisoning suspected in weaned lambs. Biliary cystadenoma in a red deer hind. These are among matters discussed in the disease surveillance report for November 2014 from SAC Consulting: Veterinary Services (SAC C VS).
Vet Rec 2015 Mar 07
PMID:Milk drop due to leptospirosis in dairy cows. 2574 87

Infectious bovine rhinotracheitis in cows and calvesMycoplasma bovis infections in cows and calvesNematodirosis in lambsPneumonic pasteurellosis in lambsEscherichia coli infections in young pigs These are among matters discussed in the Northern Ireland animal disease surveillance quarterly report for April to June 2016.
Vet Rec 2016 Aug 13
PMID:Northern Ireland disease surveillance report, April to June 2016. 2751 60

Pasteurellosis in sheepFurther cases of bovine neonatal pancytopenia in calvesIdiopathic necrotising enteritis in a three-month-old calfRuminal acidosis in sheep associated with recent feeding changesSuspected midge hypersensitivity in ewesThese are among matters discussed in the disease surveillance report for November 2016 from SAC Consulting: Veterinary Services (SAC C VS).
Vet Rec 2017 Mar 04
PMID:High prevalence of pasteurellosis in Scottish flocks. 2825 46

Northern ireland disease surveillance, july to september 2017Bibersteinia trehalosi causing septicaemic pasteurellosis in lambsAbortion due to Streptococcus pluranimalium in cattleLymphoma in cattleAcute fasciolosis in sheepErysipelas in pigsMarek's disease in chickens.
Vet Rec 2017 Nov 18
PMID:Septicaemic pasteurellosis in unvaccinated lambs in Northern Ireland. 2915 May 79

Pasteurella multocida is one of the significant causes of respiratory infection outbreaks in the Korean pig industry. Although antimicrobial treatment is an effective strategy for controlling respiratory diseases, limited information is available regarding the antimicrobial susceptibility of the pathogens infecting Korean pigs. Therefore, in this study, we evaluated the antimicrobial resistance of P multocida against widely used antimicrobials in order to enable the selection of appropriate drugs and to evaluate any trends in resistance. A total of 454 isolates of P multocida were collected from all provinces in Korea between 2010 and 2016. Antimicrobial susceptibility of all isolates was determined using a broth microdilution method. The most frequently observed resistance was to sulphadimethoxine (76.0 per cent), followed by oxytetracycline (66.5 per cent), chlortetracycline (36.8 per cent) and florfenicol (18.5 per cent). Although no consistent increase or decrease in resistance was observed for most antimicrobials, resistance to fluoroquinolones tended to increase over the study period. A variety of resistance patterns were observed, most frequently for tetracyclines and sulphonamides. These findings could provide information enabling the selection of optimal antimicrobials for efficient treatment of pneumoniae pasteurellosis in pig farms, which would impede the emergence of antimicrobial resistance.
Vet Rec Open 2018
PMID:Antimicrobial resistance of Pasteurella multocida strains isolated from pigs between 2010 and 2016. 3010 29


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