Gene/Protein Disease Symptom Drug Enzyme Compound
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The effect of ischaemic neuromyopathy in cats on peripheral muscles and nerves is described. Motor function was severely decreased distal to the stifle particularly in the cranial tibial muscles. Skin sensation was absent distal to the mid tibial or hock level. The affected muscles were often hard and painful. Improvement of motor function began two to three weeks after onset and complete recovery could occur. Conduction to the interosseous and anterior tibial muscles is absent or severely reduced initially but returned and improved within two weeks. A few peripheral nerve fibres could survive the ischaemia, others showed varying defects on the myelin sheath but the majority degenerated. Shorter term recoveries were probably due to repair of the myelin sheath. Regenerated nerve fibres were also demonstrated. The cranial tibial muscles were commonly infarcted while less severe myopathic changes were found in the gastrocnemii. Provided further ischaemic episodes can be prevented the prognosis in these cases appears good.
Vet Rec 1979 Jun 09
PMID:Ischaemic neuromyopathy in cats. 47 73

Bovine spastic syndrome (BSS) was described for the first time in 1941. The disease occurs in various-maybe even all-cattle breeds and is a chronic-progressive neuromuscular disorder that commonly affects cattle of at least three years of age. Typical clinical signs of the disease are clonic-tonic cramps of the hindlimbs that occur in attacks. Since BSS does not recover, affected animals can only be treated symptomatically by improving welfare conditions and management factors, or with physical therapy or drugs. Although still not irrevocably proven, BSS is assumed to be a hereditary disease. Therefore, affected animals should be excluded from breeding, which negatively affects economics and breeding. Besides epidemiology, clinical signs, aetiopathogenesis, diagnosis and treatment, this review discusses genetic aspects and differences to the similar disease bovine spastic paresis. Furthermore, this review also picks up the discussion on possible parallels between human multiple sclerosis and BSS as a further interesting aspect, which might be of great interest for future research.
Vet Rec 2018 06 16
PMID:Bovine spastic syndrome: a review. 2967 88