Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Antitumor activity of bamboo leaf against various transplantable mouse tumor strains, such as Sarcoma 180 and Ehrlich ascites carcinoma has previously been demonstrated by Sakai et al.7) and Yammamoto et al.9). The present investigation was undertaken to determine the antitumor activities of BLE and BLL against the spontaneous tumor induced by benzopyrene (BP) and 4-nitroquinoline-1-oxide (4NQO) in mice and rats. The possible mechanism of antitumor action was also discussed as related to Kada's Rec-assay and Ames test in vitro. The in vivo antitumor test was performed using 16 groups of mice given the following solutions ad libitum for 120 days; Groups 1-4, 5-8, 9-12 and 13-16 were given water, 1% and 10% BLe, 0.1% BLL, and each respective group was treated with no injection (control), oil/s.c., BP 1 mg/s.c., and 4NQO 0.5 mg/s.c. Rat respective group was treated 30 days after in initiation of experiment with no injection (control), oil/s.c., BP 2.4 mg/s.c. Antitumor activities of the BLE and BLL were determined by the tumor incidence index and average weight of tumor. In vitro Rec-assay, cold incubation method, and Ames test were performed in the usual manner. Antitumor activity against BP induced tumor was the highest with 1.0% BLE (0.71 mg/ml), but no significant difference was found between the groups of the 10% BLE, 0.1% BL and control. A weak trend toward DNA damage was seen in the case of BLE, in the Rec-assay. His+ revertants with S-9 mix on Salmonella typhimurium TA98 were found in the case of BLL. It was concluded that antitumor activity against BP- and 4NQO-induced tumors was the highest with 1% BLE (0.71 mg/ml), and a direct action of BLE on tumor cells was indicated.
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PMID:[Antitumor activities of bamboo leaf extracts (BLE) and its lignin (BLL)]. 679 69

Large MtTw15 tumors, which secrete growth hormone (GH) and prolactin (PRL), are composed of ovoid, elongated, and angular cells which demonstrated interdigitating processes and junctional complexes. The majority of the cells were essentially agranular, but two types of granulated cells were identifiable. One class of granulated cells contained moderate to sparse populations of round dense-cored granules measuring up to 250 nm in diameter. Rod-shaped to filamentous mitochondria with an electron-dense matrix were characteristic of a second class of granulated cells with plemorphic granules of various sizes and electron densities. Images of exocytotic release of the round dense-cored granules were frequently seen, but were not observed with the pleomorphic granules, many of which were judged to be lysosomes. Superimposition immunocytochemistry revealed hormones only in the granulated cells with round to ovoid granules. Morphometry indicated that hormone specific subpopulations of tumor cells can be identified since PRL secretory granules were significantly smaller than GH secretory granules (149 +/- 6 nm for PRL versus 221 +/- 9 nm for GH, P less than 0.001). The vast majority of immunopositive cells contained only GH or PRL, but a few were observed containing both hormones. Ovoid to irregular-shaped nuclei, large lipid inclusions, numerous free ribosomes and polyribosomes, moderate development of the rough endoplasmic reticulum, and prominent Golig profiles were characteristics of all cell types. Irrespective of the presence or absence of cytoplasmic granular elements, particles resembling viruses were encountered in many tumor cells, and these frequently appeared to be budding into the cisternae of the endoplasmic reticulum.
Anat Rec 1980 Mar
PMID:Heterogeneity of the MtTw15 mammosomatotropic tumor. II. Characterization of parenchymal cells by superimposition immunocytochemistry and electron microscopy. 699 24

Glaucoma is a disease complex in which one of several exciting factors is responsible for an elevation of the intraocular pressure beyond its normal physiological limitations. At present two types of primary glaucoma may be described for the dog, while the recognition of secondary glaucoma as a complication to lens luxation, uveitis, trauma, infection and neoplasia has long been established. Identification of the causal factor within this complex plays a necessary part in the institution of successful treatment.
Vet Rec 1980 Jul 26
PMID:The aetiology of canine glaucoma. 700 7

The Swarm chondrosarcoma, a transplantable tumor maintained in rats, has a structure similar to hyaline cartilage. The extracellular matrix contains narrow, banded collagen fibrils and proteoglycan matrix granules. The cells are filled with organelles typically involved in synthesis and secretion, including an extensive rough endoplasmic reticulum with dilated cisternae, a large Golgi apparatus dispersed throughout the cell, and secretory vacuoles which fill directly from Golgi saccules. There is only one class of secretory vacuoles, suggesting that the secretory products, collagen and proteoglycan, are packaged and secreted together. The cells also contain unusual endoplasmic reticulum, many coated vesicles and multivesicular bodies, and abnormal mitochondria. The large amount of tissue available from the tumor, and its characterization biochemically (Choi et al., '71; Oegema et al., '75) and morphologically as cartilage, make the tumor valuable as a model tissue for studies of synthesis and secretion of extracellular matrix materials.
Anat Rec 1980 Oct
PMID:Ultrastructure of the chondrocytes and extracellular matrix of the swarm rat chondrosarcoma. 721

An epidemiological survey involving 132 cats with mammary neoplasia, seen at 15 North American veterinary medical teaching hospitals, was conducted. The ratio of malignant to benign tumours was 9:1. There were 113 cases of carcinomas of all types (including two males), with adenocarcinoma being the predominant cell-type. Relative risk analysis indicated that the Siamese breed had twice the risk (P less than 0.01) of developing mammary carcinoma compared to all breeds combined. The age at diagnosis in Siamese females tended to be younger than in other breeds. Comparison of clinical and pathological features of breast cancer suggests that the cat is an appropriate surrogate for the experimental study of human breast cancer. The apparent lack of oestrogen dependency in feline breast cancer also suggests that the cat may be especially suited for evaluating therapeutic regimens for breast cancers that do not respond to hormonal manipulation.
Vet Rec 1981 May 30
PMID:Epidemiological features of feline mammary carcinoma. 725 36

Spontaneous pituitary tumors have been studied by light and electron microscopy in female C57BL/6J mice at 2 1/2, 11, 15, 22, 23, 24 and 30 months. Tumors were evident macroscopically in greater than 50% of mice 22 months or older, and greater than 80% on microscopic evaluation. Active and hypertrophied mammotrophs were the predominant cell type within the tumors at 22-30 months, often totally filling large portions of the tumor mass. Exocytosis of secretory granules was extensive from the mammotrophs, but much less abundant from other parenchymal cells. Somatotrophs and gonadotrophs were also present, and appeared active and often strikingly hypertrophied. The tumors were characterized by disruptions of parenchymal and capillary integrity which resulted in the formation of large vascular lakes lined solely by tumor cells, generally mammotrophs. Apparent metastasis of tumor cells into the vascular lakes was also observed. In 11- and 15-month mice small tumors or pretumor foci were evident in some mice on microscopic evaluation, although they were not visible macroscopically. Their degree of development was somewhat variable, but they had essentially the same features as more advanced tumors in older mice. pretumor foci were characterized by more moderate disruptions of parenchymal cell and capillary integrity; cellular hypertrophy, particularly of somatotrophs and gonadotrophs; and the presence of small vascular lakes. In 2 1/2-month mice tumors could not be localized macroscopically or microscopically, and the pituitary was composed of well-defined cell cords and an intact capillary bed. However, small focal zones of capillary and tissue disruption were apparent occasionally in 2 1/2-month mice. These findings indicate that the process of pituitary tumorigenesis in female C57BL/6J mice is initiated by midlife, with subsequent progressive development into large, mammotroph-dominated tumors.
Anat Rec 1981 Mar
PMID:Pituitary tumorigenesis in aging female C57BL/6J mice: a light and electron microscopic study. 725 86

A study of the circadian rhythm in the mitotic index (MI) of the corneal epithelium was completed in non-tumor-bearing mice and in mice bearing the Ehrlich ascites carcinoma (EAC). All mice were standardized to a light-dark cycle with 12 hours of light from 0600 to 1800 CST alternating with 12 hours of darkness from 1800 to 0600 CST. Treatments included injection with saline (SAL) or hydroxyurea (HU) at different circadian times. This investigation demonstrated that: (1) Data from untouched animals cannot serve as proper controls because treatment with SAL altered the level of the MI, but only during the diurnal, not the nocturnal, phase of the circadian cycle; (2) the presence of the EAC depressed the level of the MI, but this inhibition was only detected during the diurnal period; (3) treatment with 500 mg/kg HU injected at 0500 caused more perturbation in this rhythm than did treatment with 500 mg/kg HU at 1700; (4) when 500 mg/kg HU was given at 2000 and 0100 and 0500, the perturbation of the rhythm was greater than when 500 mg/kg HU was given at 0900 and 1400 and 1700; (5) when 3000 mg/kg HU was given at 1700 and compared to 500 mg/kg HU at 1700, little difference in the overall circadian profiles of these rhythms was observed, indicating that the circadian control mechanisms operating on the MI exerted a greater influence than did a dosage change from 500 to 3000 mg/kg HU; and (6) a comparison of the practice of plotting experimental and control data as "hours after treatment" versus using a "time of day" plot for the same data demonstrated that the "hours after treatment" plot is very misleading because it fails to account for the significant circadian oscillation in this in vivo system.
Anat Rec 1981 Apr
PMID:Circadian rhythm in mitotic index of corneal epithelium: presence of Ehrlich ascites carcinoma and treatment with saline or hydroxyurea. 727 Sep 12

1,2-dimethylhydrazine (DMH), administered weekly to mice for 20 weeks, induces tumors in the distal segment of colon. Tumors are preceded by enlargement of the mucosal glands resulting from increases in the number of total cells and 3H-thymidine labeled cells/crypt. Cells located in the crypt base normally undergo 2-3 division as they migrate toward the lumen, and they become post-mitotic in the upper crypt. It is not known if cells in these enlarged crypts have rates of turnover similar to cells in normal crypts. Groups of w/s female mice were treated with DMH (20 mg/kg body wt) for 3,8, or 16 weeks; controls were given 0.001 M EDTA. After treatment, the animals were injected with 3H-thymidine and killed one hour or 1,2,4,7 or 17 days later. Autoradiographs were prepared from sections of distal colon. The total cells/crypt column in 30 crypts/animals were counted. Crypts were divided into 10 equal segments based on the crypt length and the labeled cells/segment were counted. The relative number of labeled cells and the distribution of these cells within crypts were similar in DMH-treated and control animals after one hour. However, as the cells migrated toward the lumen, the number of labeled cells doubled after 2 days and tripled after 4 days in DMH-treated animals but only doubled during the 4 days in controls. This difference caused by retention of an increased number of dividing cells in the lower 4 segments of the crypts and suggests an increase in those cells that divide twice. In addition, increased numbers of labeled cells were retained in the upper 3 segments of DMH-treated animals after 4 days. These findings indicate that the crypt cells of DMH-treated animals are generally more immature than those of controls and this immaturity contributes to the enlargement of mucosal glands during carcinogenesis.
Anat Rec 1981 Jul
PMID:The effect of the carcinogen, 1,2-dimethylhydrazine, on turnover of 3H-thymidine labeled cells from mucosal glands of mouse colon. 727 Sep 30

Lesions found in 257 post mortem examinations of budgerigars (Melopsittacus undulatus) are recorded. The commonest disease was neoplasia, principally of the gonads, kidneys and fat. Hepatitis and focal hepatic necrosis, thyroid dysplasias and septicaemias were also common. A great variety of other disease processes occurred; each affected only a few birds.
Vet Rec 1980 Jan 05
PMID:A survey of causes of mortality in budgerigars (Melopsittacus undulatus). 735 54

Rats bearing adrenocortical carcinoma 494 were injected daily for 7, 14, or 21 days with aminoglutethimide (AG) or o,p'-DDD. Reversibility of these steroidogenic inhibitors was determined by injecting other animals for either 14 or 21 days and sacrificing them 14 days later. While the drugs had little effect on body or tumor growth, plasma corticosterone levels were reduced a maximum of 88% in normal and 95% in tumor-bearing rats during AG chemotherapy. These levels were unaltered in normal rats by o,p'-DDD and reduced a maximum of 64% in tumor-bearing animals. Relative adrenal weights generally increased during chemotherapy and then returned to control levels. These changes were mainly due to alterations in the lipid and mitochondrial volume fractions. Lipid increased with both drugs while mitochondria increased with o,p'-DDD and decreased with AG. Cholesterol ester levels paralleled the lipid stereology more closely with AG than o,p'-DDD. With both drugs the most notable changes in tumor fine structure was a decrease in mitochondrial internal membranous vesicles and matrical density. Adrenal mitochondria had the irregular, elongated forms characteristic of tumor-bearing animals and were vacuolated (AG) or had internal rings (o,p'-DDD). The large lipid droplets observed during chemotherapy with both drugs were replaced by numerous small droplets in recovery periods.
Anat Rec 1980 Sep
PMID:Fine structural and biochemical effects of aminoglutethimide and o,p'-DDD on rat adrenocortical carcinoma 494 and adrenals. 745 28


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