Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An outbreak of severe indurative mastitis in newly calved cows, from which Prototheca zopfii was isolated, is described. The refractory nature of this type of mastitis and the ineffectiveness of the presently available intramammary preparations are highlighted.
Vet Rec 1985 Mar 30
PMID:Bovine mastitis caused by Prototheca zopfii: a case study. 400 43

The efficacy of a dry cow cerate in protecting the dry ewe against mastitis was tested in three flocks. Of 931 ewes, 462 were infused, shortly after their lambs were weaned, with a dry cow cerate containing 1 g procaine penicillin and 0.5 g dihydrostreptomycin sulphate. The remaining 469 served as untreated controls. At tupping, when the sheep were examined for clinical evidence of mastitis, 21 cases (4.5 per cent) were recorded among the controls but only seven (1.5 per cent) among the treated ewes. There was variation in the distribution of cases between individual flocks but overall the incidence of mastitis in the treated sheep was lower and significantly different from that among the control ewes.
Vet Rec 1981 Jul 18
PMID:Prevention of post weaning mastitis in ewes. 617 Jan 57

A within herd comparison of teat dipping and dry cow therapy (full treatment) with only selective dry cow therapy (partial treatment) was carried out in six commercial dairy herds for a two year period. In four herds, the incidence of clinical mastitis was 2 to 12 per cent higher in the partial treatment group. In another herd, in which the pattern of clinical mastitis isolates was unusual in that minor pathogens were isolated from 30 per cent of mastitis cases, the incidence was 43 per cent higher in the partial treatment group. In the remaining herd the incidence was 10 percent higher in the full treatment group. Streptococcus uberis mastitis was more common in the partial treatment groups of five herds; coliform mastitis was more common in the full treatment groups of two herds and similar in both groups in the other herds. High rates of coliform mastitis were associated with poor herd environmental conditions but this was not true for Strep uberis mastitis. Rates of staphylococcus aureus and Strep dysgalactiae mastitis were low in all herds. The level of major pathogen infection in cows completing the trial in all herds increased in the partial treatment group from 5 per cent of quarters at the start to 12 per cent at the finish of the trial. In the full treatment group, however, there was only a small increase in this level. In contrast, levels of Corynebacterium bovis infection increased by 17 per cent in both treatment groups. Continued use of teat dipping and dry cow therapy was associated with a higher rate of coliform mastitis in two of the three herds where there were poor standards of hygiene and husbandry.
Vet Rec 1983 Apr 02
PMID:Within herd comparison of teat dipping and dry cow therapy with only selective dry cow therapy in six herds. 619 Feb 99

A retrospective study was performed at the New York State college of veterinary medicine, ambulatory clinic to determine the prognosis for cows with peracute or acute coliform mastitis. Eighty-eight cows were identified by their clinical signs and positive culture of coliform organisms. In 59.1 per cent of the affected cows the quarters returned to a milk-like secretion approximately one month following treatment. The 59.1 per cent was composed of 37.5 per cent (of the initial 88 cows), which milked in the affected gland the following lactation, 11.4 per cent which were culled, and 10.2 per cent which had not yet calved and begun their next lactation. The remainder of the affected cows failed to return to milk in the affected quarter that lactation. This percentage consisted of 17.0 per cent which were culled for hypogalactia, 6.8 per cent which died during the attack, 4.6 per cent in which the affected quarters were rendered inactive with an irritant, 1.1 per cent in which the outcome was undetermined since they had not begun their next lactation and 11.4 per cent which remained in the herd. Of the 11.4 per cent, half produced milk in the affected quarter the following lactation, and half failed to return to milk.
Vet Rec 1983 Apr 23
PMID:Prognosis for cows with severe clinical coliform mastitis. 634 57

A zero-grazed herd of approximately 400 cows had a significant mastitis problem associated with Escherichia coli and Streptococcus uberis during a study over three and a half years. Dry cow therapy and post-milk teat dipping effectively controlled staphylococci and the bulk milk cell count averaged less than 400 X 10(3) cells/ml, but over 1800 clinical cases of mastitis occurred over this period, 32 per cent of which were associated with E coli and 25 per cent with Str uberis. Only 8 per cent of the cases associated with E coli showed obvious systemic disturbance and 75 per cent were cured following penicillin and streptomycin treatment. The incidence was highest during spring and summer when the housed cows were dirtiest. Gross teat-end contamination came mainly from sources other than cubicle bedding, and changing the bedding from sawdust to sand did not alter the incidence of clinical mastitis. It was not possible to maintain adequate cleanliness either inside or outside the parlour, nor maintain a trouble-free milking apparatus. The costs of mastitis in this herd during one year are calculated.
Vet Rec 1983 Oct 29
PMID:Mastitis in a large, zero-grazed dairy herd. 635 60

The conductivity of milk from 164 cows in four herds was measured. There were significant differences between the normal and the mastitic quarters in each of the four herds. However, there was a marked difference in conductivity levels between the herds, the mean conductivity of the normal quarters in one herd being higher than that of the mastitic quarters in another herd. In a trial using a hand-held mastitis detector on 123 cows from three herds, 91 per cent of the 106 mastitic quarters were detected. However, 33 per cent of the 315 normal quarters also gave a positive reading.
Vet Rec 1984 Mar 10
PMID:Use of a conductivity meter for the detection of subclinical mastitis. 637 1

The results of tests to determine the microflora and somatic cell content of 483 milk samples from 250 dairy goats in the North of Scotland are presented. Milk from uninfected udders had extremely low levels of bacterial contamination, 80 per cent of such samples having less than 100 bacteria/ml. One quarter of all samples were infected, the organisms isolated being coagulase negative staphylococci (83.5 per cent), coagulase positive staphylococci (12.4 per cent) streptococci (3.3 per cent) and Escherichia coli (0.8 per cent). Streptococcus agalactiae was not detected. Somatic cell count levels were higher than those usually found in cows' milk: 33 per cent more than 2,000,000/ml; 22 per cent between 1,000,000 and 2,000,000/ml; 25 per cent between 500,000 and 1,000,000/ml; 22 per cent less than 500,000/ml. The levels of cell counts were similar for uninfected halves and halves infected with coagulase negative staphylococci. Halves infected with coagulase positive staphylococci had much higher cell counts, eg, 73 per cent in excess of 2,000,000/ml. The interpretation of tests based on somatic cell content as indicators of mastitis in goats is discussed.
Vet Rec 1984 Mar 31
PMID:Microflora and somatic cell content of goat milk. 637 3

The value of cefoperazone in mastitis therapy was assessed in the mouse model of mastitis primarily by its effect on bacterial cell numbers in the gland. In addition histological studies showed that the drug was not an irritant in the mammary gland. Pharmacokinetic studies showed that it was slowly absorbed from the gland (six days to absorb 500 micrograms) but was easily removed by milking. In ascending order of efficacy cefoperazone (500 micrograms/gland) was active against four-hour-old intramammary infections caused by Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Streptococcus agalactiae and Strep uberis. The effect against Staph aureus was titrated down to a dose of 50 micrograms/gland. Cefoperazone was not bactericidal against intracellular staphylococci but it did sensitise them to the action of lytic enzyme. Cefoperazone and cloxacillin behaved similarly against progressive staphylococcal mastitis. Both antibiotics significantly reduced the bacterial numbers when four-hour-old infections were treated but the effect on 26-hour-old infections was perceptible only when each antibiotic was assayed against saline treatment in the mouse. The results suggest that further studies in dairy cattle should be undertaken.
Vet Rec 1984 Jun 23
PMID:Assessment in the mouse of cefoperazone as a treatment for mastitis. 646 27

An outbreak of cutaneous staphylococcosis caused high mortality among newborn and very young rabbits. The most typical lesions were exudative dermatitis in the youngest, subcutaneous abscesses in rabbits of all ages and mastitis in lactating does. Generalised staphylococcosis was a frequent secondary manifestation of the disease.
Vet Rec 1984 Mar 31
PMID:Cutaneous staphylococcosis in rabbits. 653 26

A culling survey in 80 Friesian dairy herds in East Anglia over four years investigated the age at, and reasons for, disposal or death. Failure to conceive was the most important reason except in very old animals. Low production was the second most common reason, culling being particularly heavy in the first two lactations. Mastitis was the major disease influencing wastage and increased with age until the sixth lactation. The percentage of culls for multiple reasons increased with age. There was a high proportion of young animals in most herds and the median lactating life of cows was about three years, equivalent to three lactations. Considerable variation in herd life demonstrated that there was substantial scope for improving herd longevity. Long living herds culled fewer animals for breeding problems in the early lactations and for mastitis in the later ones, enabling more animals to be culled as surplus and for production factors.
Vet Rec 1983 Jul 30
PMID:Culling and wastage in dairy cows in East Anglia. 668 22


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>