Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the past 20 years the equine population of Great Britain and Ireland has increased with the result that the practising veterinary surgeon is more frequently called upon to advise on equine problems. A significant portion of this advice is concerned with the examination of horses showing signs of this advice is concerned with the examination of horses showing signs of respiratory disease. Numerous pathogens, which include viruses, bacteria, parasites and moulds invade the respiratory tract causing similar signs of illness. It is therefore difficult to provide an aetiological diagnosis based on a clinical examination. Field studies supported by laboratory investigations have established that influenza and herpes viruses are frequently responsible for outbreaks of disease. Epidemiological studies suggest that other factors including the immune state of the equine population influence the distribution and severity of respiratory disease. The aetiology, diagnosis, treatment and control of equine infectious respiratory disease are discussed below.
Vet Rec 1975 Jan 11
PMID:Equine infectious respiratory disease. 16 16

A novel strain of equine influenza virus, influenza A/equine/Jilin (China)/1/89, has emerged which is genetically distinct from all earlier strains of equine influenza. It is therefore possible that the vaccines against equine influenza may be unable to protect horses against disease caused by this virus strain. In vitro serological assays established that there were low levels of immunological cross-reactivity between the new virus, the current vaccine strains and the strains of equine-2 influenza virus now in circulation.
Vet Rec 1992 Oct 24
PMID:Cross-reactivity of existing equine influenza vaccines with a new strain of equine influenza virus from China. 133 65

During the autumn of 1988 an outbreak of canine infectious tracheobronchitis, which seemed to be more infectious than usual, occurred throughout Scandinavia. Paired serum samples and bacterial swabs were collected from 52 dogs with clinical signs of infectious tracheobronchitis in three districts of Norway. The results revealed a fourfold or greater rise in the titre of antibodies against canine parainfluenza virus in 79 per cent of the cases, strongly suggesting that the virus was of aetiological importance in the outbreak. Bordetella bronchiseptica was not isolated from the diseased dogs, and they showed no rise in the titres of antibodies against influenza virus, reovirus or adenovirus.
Vet Rec 1990 May 12
PMID:Serological, bacteriological and clinical observations on an outbreak of canine infectious tracheobronchitis in Norway. 216 80

During an epizootic of equine influenza in Norway caused by influenza A/equine (H3N8) virus the efficacy of rapid virus diagnosis by the indirect immunofluorescence technique was evaluated. The antiserum used in the test was a polyclonal influenza A virus antiserum with reactivity directed mainly against the common nucleoprotein and matrix protein. This antiserum possessed sufficient reactivity for the detection of virus-infected exfoliated nasopharyngeal cells. Nasopharyngeal smear samples from 92 horses were examined and a positive diagnosis was obtained for 57 (62 per cent). Paired serum samples were collected from 62 horses and, compared with the haemagglutination inhibition test, the rapid virus diagnosis test had a specificity and sensitivity of 95 per cent and 80 per cent, respectively.
Vet Rec 1990 Jun 02
PMID:Rapid diagnosis of equine influenza. 216 75

The irradiation damage of the crystals of proteins as well as nucleic acid is reduced almost exponentially even below the liquid nitrogen temperature down to 8K provided that the specimen area under illumination is cooled down. A cryo-stage cooled by superfluid helium is designed for the high resolution electron microscope based on the idea of the helium evaporation refrigerator with a capillary which was developed by Delong et al. We also developed a new top-entry-type cryo-transfer system for this superfluid cryo-electron microscope. The images of chlorinated Cu-phthalocyanine are taken to estimate the resolution attainable by this cryo-stage at 1.5 K with accelerating voltage of 400 kV. The optical diffraction confirms the resolution of 0.26 nm. The complexes of rec A proteins and DNA molecule are clearly visible in vitreous ice. A new membrane structure of the influenza virus is observed in the case of influenza A virus.
 ...
PMID:High resolution cryo-electron microscopy for biological macromolecules. 280 74

Serum samples from pig herds in Great Britain have been examined for antibodies to influenza virus since 1968. Antibodies to H3N2 virus strains have been found since 1968 and the serological data presented here suggests that H3N2 virus strains continue to persist in the pig population. An outbreak of acute respiratory disease occurred in a 400-sow unit. The outbreak was characterised by coughing, anorexia, fever, inappetence and loss of condition. The gilts and weaners were affected and the morbidity approached 100 per cent. An influenza A virus designated A/Swine/Weybridge/117316/86 (H1N1) was isolated from the herd and 28 paired serum samples from the affected animals showed increases in the haemagglutination inhibition titres to this isolate. Haemagglutinin and neuraminidase characterisation indicated that the virus is similar to H1N1 viruses isolated recently from pigs in Europe. A total of 91 herds experiencing respiratory disease were investigated, of which 42 gave positive reactions in the haemagglutination inhibition test. Antibodies to A/Port Chalmers/1/73 (H3N2) were also detected in some of the herds but it is not known whether this strain plays any role in the current respiratory disease problems in pigs.
Vet Rec 1987 Jul 18
PMID:Outbreaks of classical swine influenza in pigs in England in 1986. 282 Jan 11

The duration of immunity as measured by virological, serological and clinical responses following infection with influenza A/equine/Newmarket/79 (H3N8) was assessed in repeated challenge experiments in which ponies were infected by exposure to aerosols of infectious virus. Previous infection stimulated complete clinical protection which persisted for at least 32 weeks as demonstrated by the absence of febrile responses and coughing in two groups of ponies infected 16 weeks or 32 weeks after the first infection. Partial clinical protection persisted for over a year as demonstrated by the absence of coughing and a reduction in the number of febrile responses in a group of ponies infected 62 weeks after their first infection. These results contrasted with those observed in immunologically naive control ponies which developed pyrexia, dyspnoea and nasal discharge and coughing. The kinetics of virus specific antibody production in primary and secondary infections with equine influenza were studied by the single radial haemolysis test and a radioisotopic antiglobulin binding assay which measured virus specific IgGab antibody isotype. Antibody to the haemagglutinin, as measured by the single radial haemolysis test, declined rapidly after primary infection whereas the IgGab responses to whole virus antigens persisted for longer. The single radial haemolysis test was therefore particularly useful for the detection of antibody responses in multiple infections or exposures to influenza antigens. The radioisotopic antiglobulin binding assay was more sensitive for identifying infections which had occurred more than six months previously, as evidenced by anamnestic IgGab responses in ponies with low levels of antibody before rechallenge.
Vet Rec 1988 Feb 06
PMID:Duration of circulating antibody and immunity following infection with equine influenza virus. 283 50

An outbreak of equine viral arteritis in the American state of Kentucky led to a temporary ban being imposed by France, Ireland and the UK on the importation of horses from the USA during 1984. Sporadic cases of influenza caused by the type 2 strain of the virus were confirmed in France throughout the year and cases of strangles in thoroughbred mares and foals were reported from all three countries. No cases of contagious equine metritis were confirmed among the thoroughbred breeding population, although a number of outbreaks of the abortion form of rhinopneumonitis occurred. A small number of clinical cases of equine infectious anaemia were confirmed in France.
Vet Rec 1985 Feb 09
PMID:Infectious disease incidence among horses in France, Ireland and the United Kingdom during 1984. 298 33

Recombinant interferon-alpha-2C (rec. IFN alpha-2C) and recombinant interferon-gamma (IFN-gamma) was studied in 12 patients with metastasized renal cell carcinoma. 8 patients were treated with IFN-alpha-2C: 1 patient achieved a complete remission, 2 patients showed mixed responses, and 2 had stabilisation of their disease. In 3 patients progressive disease was observed. IFN-gamma was studied in 4 patients; 2 patients showed stable and 2 progressive disease. Side effects of IFN-alpha treatment included influenza-like symptoms, moderate hematological toxicity and neurological symptoms. During treatment with IFN-gamma similar side effects were observed, although fever generally was more pronounced. All symptoms ceased after dosis reduction or discontinuation of treatment.
 ...
PMID:[Interferon (IFN) therapy (recombinant IFN-alpha-2C or recombinant IFN-gamma) in metastasized hypernephroma]. 393 90

Two hundred serum samples from Texel and Texel crossbred sheep (non-indigenous breeds) and 200 from indigenous Northern Ireland breeds (mainly Blackface, Cheviot and Border Leicester crosses) were tested for antibodies to parainfluenza virus types 1, 2 and 3, respiratory syncytial virus, bovine adenovirus (subgroups 1 and 2), influenza type A, maedi-visna virus and bovine virus diarrhoea virus. The percentage of animals with antibodies to parainfluenza virus 3 (50 to 56 per cent) and adenovirus subgroups 1 and 2 (70 to 90 per cent) was comparable in both groups. Infection of sheep with subgroup 2 adenoviruses has not previously been reported. In the case of respiratory syncytial virus and bovine virus diarrhoea virus, the percentage of animals positive was higher in the non-indigenous group (55.5 and 53 per cent, respectively) than in indigenous breeds (18.5 and 11 per cent, respectively). No antibodies were detected to parainfluenza virus 1 or 2, influenza A or maedivisna virus.
Vet Rec 1984 Oct 20
PMID:Survey for antibodies to respiratory viruses in two groups of sheep in Northern Ireland. 609 11


1 2 3 4 5 Next >>